A5013683567- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Sleep and related disorders
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tracheal and airway disorders
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Physics of Superconductivity and Magnetism
- Regulation of Appetite and Obesity
- Cardiovascular Health and Disease Prevention
- Superconductivity in MgB2 and Alloys
- Pediatric health and respiratory diseases
- Lipid metabolism and disorders
- Heart Rate Variability and Autonomic Control
- Dysphagia Assessment and Management
- Chemical and Physical Properties of Materials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastroesophageal reflux and treatments
- Lung Cancer Treatments and Mutations
- Metabolism and Genetic Disorders
- Circadian rhythm and melatonin
Shanghai Sixth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Institute for Breathing and Sleep
2018-2023
Shanghai Institute of Hematology
2015
Ruijin Hospital
2012
Chronic intermittent hypoxia (CIH) and chronic sleep fragmentation (CSF) are two cardinal pathological features of obstructive apnea (OSA). Dietary obesity is a crucial risk intermediator for OSA metabolic disorders. Gut microbiota affect hepatic adipose tissue morphology under conditions CIH or CSF through downstream metabolites. However, the exact relationship unclear. Herein, chow high-fat diet (HFD)-fed mice were subjected to 10 weeks each compared normoxia (NM) normal (NS) controls. 16S...
In antibody responses, mutated germinal center B (B GC ) cells are positively selected for reentry or differentiation. As the products from GCs, memory and antibody-secreting (ASCs) support high-affinity long-lasting immunity. Positive selection of is controlled by signals received through cell receptor (BCR) follicular helper T (T FH cell–derived signals, in particular costimulation CD40. Here, we demonstrate that effector cytokine interleukin-21 (IL-21) joins BCR CD40 supporting reveal...
Abstract Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea (OSA). Thus, we applied a metabolomics approach to analyze metabolites three groups of participants: polysomnography (PSG)-confirmed OSA, simple snorers (SS) and normal subjects. Ultra-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry gas were used. A total 21 31 differentially expressed the SS OSA groups, respectively. Patients had 18...
Rationale: Previous genetic studies of obstructive sleep apnea (OSA) have limitations in terms precise case definition, integrated quantitative traits, and interpretation functions; thus, the heritability OSA remains poorly explained. Objectives: To identify novel variants associated with objective sleep-related traits to explore their functional roles. Methods: A genome-wide association study was performed 20,590 Han Chinese individuals (5,438 15,152 control samples). Human samples point...
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and performance among middle-aged patients OSA normal cognition remain unclear. To investigate the CPAP therapy over 12 months performance. In this multicenter, randomized clinical trial, we randomly assigned 148 participants an apnea-hypopnea index ≥15/hour into two groups: receiving best supportive care (BSC); BSC alone. primary...
Several cross-sectional studies have reported associations between oral diseases and obstructive sleep apnea (OSA). However, there been no reports regarding the structure composition of microbiota with simultaneous evaluation potential perturbed metabolic profiles in pediatric OSA.An integrated approach, combining metagenomics based on high-throughput 16S rRNA gene sequencing, metabolomics ultra-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry gas...
The high cost and low availability of polysomnography (PSG) limits the timely diagnosis OSA. Herein, we developed validated a simple-to-use nomogram for predicting We collected analyzed cross-sectional data 4162 participants with suspected OSA, seen at our sleep center between 2007 2016. Demographic, biochemical anthropometric data, as well parameters were obtained. A least absolute shrinkage selection operator (LASSO) regression model was used to reduce dimensionality, select factors,...
Previous studies have reported the effects of obstructive sleep apnea (OSA) and cardiometabolic disorders on cardiovascular disease (CVD), but associations between biomarkers two cardinal features OSA (chronic intermittent hypoxia fragmentation) their interactions CVD in populations remain unclear. A total 1727 subjects were included this observational study. Data overnight polysomnography parameters, biochemical biomarkers, anthropometric measurements collected. Metabolic syndrome (MS),...
To evaluate the prevalence, characteristics, and respiratory arousal threshold (ArTH) of Chinese patients with positional obstructive sleep apnea (POSA) according to Cartwright Classification (CC) Amsterdam Positional Obstructive Sleep Apnea (APOC).A large-scale cross-sectional study was conducted in our center from 2007 2018 analyze clinical polysomnography (PSG) data POSA patients. Low ArTH defined based on PSG indices.Of 5,748 OSA patients, 36.80% met CC criteria, 42.88% APOC for POSA....
Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on inflammation and gut microbiota remodelling. However, whether how alleviates CIH-induced dysfunction remains unclear. C57BL/6 J mice Caco-2 cell line were treated. We evaluated function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran. Immunohistochemical...
REBa2Cu3Oy (RE123 or REBCO, RE = rare earth elements) bulk high-temperature superconductors have a potential perspective for large-scale engineering applications. However, the cost of REBCO production is rather high, considering high failure rates, expensive materials, and Pt Ag addition. Using cold-seeding in top-seeded melt growth, simple feasible process, we succeeded recycling failed (RE Y) bulks. The distinctive feature this process use YBCO-buffered NdBCO films as seeds, which thermal...
Obstructive sleep apnea (OSA) is thought to be associated with dyslipidemia. However, differences concerning dyslipidemia during rapid eye movement (REM) and non-REM (NREM) have yet determined. This study was designed explore the association between lipid profiles OSA REM or NREM sleep. a clinical cohort. A total of 2,619 participants at least 30 minutes were included. Sleep variables fasting [total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), high-density (HDL-C),...
Background Several clinical studies have demonstrated that pediatric obstructive sleep apnea (OSA) is associated with dysbiosis of airway mucosal microbiota. However, how oral and nasal microbial diversity, composition, structure are altered in OSA has not been systemically explored.Methods 30 polysomnography-confirmed patients adenoid hypertrophy, controls who did were enrolled. Swabs from four surface tissue sites (tongue base, soft palate, both palatine tonsils, adenoid) one swab anterior...
Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, mediating relationships between OSA, intestinal inflammation.