A5001638119- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Luminescence and Fluorescent Materials
- Advanced Glycation End Products research
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Cerebrovascular and genetic disorders
- Neural dynamics and brain function
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Carbon and Quantum Dots Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Microfluidic and Bio-sensing Technologies
- Advancements in Transdermal Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Peroxisome Proliferator-Activated Receptors
- Muscle Physiology and Disorders
- Layered Double Hydroxides Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Photocatalysis Techniques
- Polymer Surface Interaction Studies
- Obstructive Sleep Apnea Research
University of Rhode Island
2018-2025
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2023-2025
Jilin University
2025
University of Science and Technology Beijing
2025
Shandong Agricultural University
2023-2024
Suzhou Municipal Hospital
2024
Ludong University
2024
Brandeis University
2021-2023
City University of Hong Kong
2013-2017
Nitrogen and sulfur codoped carbon dots (CDs) were prepared from garlic by a hydrothermal method. The as-prepared CDs possess good water dispersibility, strong blue fluorescence emission with fluorescent quantum yield of 17.5%, excellent photo pH stabilities. It is also demonstrated that the are resistant to interference metal ions, biomolecules, high ionic strength environments. Combining low cytotoxicity properties, could be used as an probe for cellular multicolor imaging. Moreover,...
Computer-controlled microfluidics would advance many types of cellular assays and microscale tissue engineering studies wherever spatiotemporal changes in fluidics need to be defined. However, this goal has been elusive because the limited availability integrated, programmable pumps valves. This paper demonstrates how a refreshable Braille display, with its grid 320 vertically moving pins, can power integrated valves through localized deformations channel networks within elastic silicone...
Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery distribution drug molecules has received growing interest. Herein, a self-monitored self-delivered photosensitizer-doped FRET nanoparticle (NP) system (DDS) designed for this purpose. During preparation, donor/acceptor pair perylene 5,10,15,20-tetro (4-pyridyl) porphyrin (H2TPyP) co-doped into chemotherapeutic anticancer curcumin (Cur) matrix. In system, Cur works as agent. meantime, green fluorescence...
Lanthanide-doped upconversion nanoparticles with a suitable surface coating are appealing for biomedical applications. Because high-quality typically prepared in an organic solvent and passivated by hydrophobic oleate ligands, convenient reliable method the modification of is thus highly desired to satisfy downstream biological investigations. In this work, we describe facile versatile strategy displacing native ligands on diversity hydrophilic molecules. The ligand-exchange procedure...
A carbon dot-based fluorescence turn-on sensor for hydrogen peroxide with a photo-induced electron transfer mechanism was developed.
Killing two birds with one stone: a p53 activator was conjugated cisplatin as single anticancer agent, leading to synergistically improved cytotoxicity.
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and performance among middle-aged patients OSA normal cognition remain unclear. To investigate the CPAP therapy over 12 months performance. In this multicenter, randomized clinical trial, we randomly assigned 148 participants an apnea-hypopnea index ≥15/hour into two groups: receiving best supportive care (BSC); BSC alone. primary...
The advancement of biocompatible nanoplatforms with dual functionalities diagnosis and therapeutics has been strongly demanded in biomedicine recent years. In this work, we report the synthesis characterization polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging enhanced photothermal therapy (PTT) tumors. Au NSs were firstly formed via a seed-mediated growth method then stabilized thiolated polyethyleneimine (PEI-SH), followed by deposition pD on their...
Carbon nanoparticles (CNPs) with strong blue emission are synthesized using a microwave-assisted hydrothermal method. The fluorescence of the CNPs can be completely quenched by Hg2+ through an effective electron or energy transfer process due to synergetic electrostatic interaction and metal-ligand coordination. Based on this, system containing Hg2+-quenched (CNP-Hg2+) is designed sensitive selective turn-on fluorescent probe towards cysteine (a type mercapto biomolecule) detection limit 15...
Nanoscale size controllable and surface modifiable zeolitic imidazolate framework-8–poly(acrylic acid sodium salt) (ZIF-8–PAAS) nanocomposites are fabricated by employing PAAS nanospheres as a soft template. These ZIF-8–PAAS have different sizes ranging from 30 to 200 nm exhibit crystallinity, pH sensitivity. can be employed vectors deliver doxorubicin for anticancer therapy, leading greatly enhanced drug therapeutic efficacy when tested in cell lines mice model. Systematic toxicity...
Dissolving polymer microneedles have attracted much attention for their biocompatibility, fast dissolution, and high drug loading. Among them, polyvinylpyrrolidone (PVP) is widely used, but its water absorption poor mechanical properties constrain broad applications. Herein we show that adding cyclodextrin (CD) to form PVP-CD inclusion complexes can alleviate these problems. The of PVP was reduced by 36-40% at different RHs as the formed. Attractively, 10 20 days remained almost same while...
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we observed an atypical Aβ deposit, referred to as the coarse-grained plaque. In this study, evaluate plaque's association and perform in-depth immunohistochemical morphological characterization. The plaque, a relatively large (Ø ≈ 80 µm) having multiple cores Aβ-devoid pores, was prominent neocortex. plaque semi-quantitatively scored middle...
Healthy neuronal networks rely on homeostatic plasticity to maintain stable firing rates despite changing synaptic drive. These mechanisms, however, can themselves be destabilizing if activated inappropriately or excessively. For example, prolonged activity deprivation lead rebound hyperactivity and seizures. While many forms of homeostasis have been described, whether how the magnitude is constrained remains unknown. Here, we uncover negative regulation cortical network by PARbZIP family...
Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ peptides upon and within cerebral vasculature, which leads to loss vascular integrity contributes disease progression in Alzheimer's (AD). We investigate structure human-derived Aβ40 fibrils obtained from patients diagnosed sporadic or familial Dutch-type (E22Q) CAA. Using cryo-EM, two primary structures are identified containing elements that have not been observed vitro fibril structures. One population...
This paper describes the use of arrays horizontally-oriented reservoirs to deliver liquids through microchannels at a constant flow rate over extended periods time (hours days). The horizontal orientation maintains hydraulic pressure drop across microfluidic channels even as volumes within change time. For given channel–reservoir system, magnitude velocity depends linearly on height difference between reservoirs. simple structure and operation mechanism make this pumping system versatile. A...
Delivery of drugs and biomolecules into skin has significant advantages. To achieve this, herein, a nanomaterial‐strengthened dissolving microneedle patch for transdermal delivery is reported. The comprises thousands microneedles, which are composed polymers, nanomaterials, drug/biomolecules in their interior. With the addition mechanical property generally weak polymers can be dramatically improved without sacrificing dissolution rate within skin. In this experiments, layered double...
Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles reported. These have loading capacity 27 wt% are able to enter cell nuclei dramatically improve the MTX.
Abstract Protein/subunit vaccines often require external adjuvants to induce protective immunity. Due the safety concern of chemical adjuvants, physical were recently explored boost vaccination. Physical use energies rather than chemicals stimulate tissue stress and endogenous danger signal release Here we present potency non-invasive radiofrequency treatment intradermal vaccination in murine models. We show can increase protein antigen-induced humoral cellular immune responses with adjuvant...