A5082160309- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Hearing, Cochlea, Tinnitus, Genetics
- Animal Nutrition and Physiology
- Hearing Loss and Rehabilitation
- Visual perception and processing mechanisms
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Retinal Development and Disorders
- Vestibular and auditory disorders
- Single-cell and spatial transcriptomics
- Olfactory and Sensory Function Studies
- Animal Vocal Communication and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Marine animal studies overview
- Phytase and its Applications
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Ion channel regulation and function
- Acoustic Wave Phenomena Research
- Autism Spectrum Disorder Research
Brandeis University
2016-2025
University of Pennsylvania
2024
College of St. Scholastica
1990-2023
Heinrich Heine University Düsseldorf
2019
North Dakota State University
2018
University of Pittsburgh
2017
Janelia Research Campus
2017
University of Arkansas System
2016
Bionics Institute
2008-2015
University of Oregon
2007-2015
Cortical neurons receive synaptic inputs from thousands of afferents that fire action potentials at rates ranging less than 1 hertz to more 200 hertz. Both the number and their large dynamic range can mask changes in spatial temporal pattern activity, limiting ability a cortical neuron respond its inputs. Modeling work based on experimental measurements indicates short-term depression intracortical synapses provides gain-control mechanism allows equal percentage rate rapidly slowly firing...
How different is local cortical circuitry from a random network? To answer this question, we probed synaptic connections with several hundred simultaneous quadruple whole-cell recordings layer 5 pyramidal neurons in the rat visual cortex. Analysis of dataset revealed nonrandom features connectivity. We confirmed previous reports that bidirectional are more common than expected network. found highly clustered three-neuron connectivity patterns overrepresented, suggesting tend to cluster...
It is well known that visual cortical neurons respond vigorously to a limited range of stimulus orientations, while their primary afferent inputs, in the lateral geniculate nucleus (LGN), all orientations. Mechanisms based on intracortical inhibition and/or converging thalamocortical afferents have previously been suggested underlie generation orientation selectivity; however, these models conflict with experimental data. Here, 1:4 scale model 1700 microns by 200 microms region layer IV cat...
Rett Syndrome (RTT) is a devastating neurological disorder that caused by mutations in the MECP2 gene. Mecp2 -mutant mice have been used as model system to study disease mechanism. Our previous work has suggested MeCP2 malfunction neurons primary cause of RTT mouse. However, neurophysiological consequences remain obscure. Using whole-cell patch-clamp recordings cortical slices, we show spontaneous activity pyramidal reduced mice. This decrease not change intrinsic properties recorded...
Cortical synapses exhibit several forms of short-term plasticity, but the contribution this plasticity to visual response dynamics is unknown. In part, because simple patterns stimulation used probe in vitro do not correspond activity that occur vivo. We have developed a method quantitatively characterizing at cortical permits prediction responses arbitrary stimulation. Synaptic were recorded intracellularly as EPSCs and extracellularly local field potentials layer 2/3 rat primary slices...
The underlying brain injury that leads to autism has been difficult identify. diagnostic criteria of the disease are not readily associated with any region or system, nor they mimicked by vascular accidents, tumors, degenerative neurological diseases occurring in adults. Fortuitously, a recent report induced thalidomide exposure provides evidence originates an at time closure neural tube. human data suggest initiating lesion includes motor cranial nerve nuclei. To test this hypothesis, we...
Spike discharges from single fibers in the auditory nerve of anesthetized cats were recorded with micro-electrodes. Rates discharge measured as functions frequencies and levels either tones or two presented simultaneously. We found that presence a second tone diminishes responses to first if appropriate stimulus parameters are chosen. All tested showed this two-tone inhibition. Response areas inhibitory defined isorate contours. The general characteristics be similar for population over 300 fibers.
We explore the effects of short-term synaptic depression on temporal dynamics V1 responses to visual images by constructing a model simple cell. Synaptic is modeled basis previous detailed fits experimental data. A component operating in range hundreds milliseconds can account for number unique characteristics cortical neurons, including bandpass nature frequency–response curves, increases response amplitude and cutoff frequency transient stimuli, nonlinear summation, contrast-dependent...