A5103107323- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Light effects on plants
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Visual perception and processing mechanisms
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Spaceflight effects on biology
- Hormonal Regulation and Hypertension
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Advanced Fluorescence Microscopy Techniques
- Neurogenesis and neuroplasticity mechanisms
- Lipid Membrane Structure and Behavior
- Olfactory and Sensory Function Studies
- RNA regulation and disease
- Neurological disorders and treatments
- Bipolar Disorder and Treatment
Ewha Womans University
2016-2024
Korea Institute of Science and Technology
2012-2023
Korea Institute of Brain Science
2013-2022
Korean Association Of Science and Technology Studies
2013-2022
Korea University of Science and Technology
2018
Korea University
2014-2016
Seoul National University
2005-2015
Dongnam Institute of Radiological & Medical Sciences
2014
Korea Institute of Radiological and Medical Sciences
2007
Harvard University Press
2005-2006
Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a robust daily oscillation, which has been thought to be driven by the master circadian clock in suprachiasmatic nucleus of hypothalamus via hypothalamus-pituitary-adrenal axis. However, we show that gland its own and peripheral clockwork tightly linked steroidogenesis steroidogenic acute regulatory protein. Examination mice adrenal-specific knockdown canonical protein BMAL1 reveals machinery required...
In mammalian neocortex, the orderly arrangement of columns neurons is thought to be a fundamental organizing principle. primary visual cortex (V1), respond preferentially bars particular orientation, and, in many mammals, these orientation-selective cells are arranged semiregular, smoothly varying map across cortical surface. Curiously, orientation maps have not been found rodents or lagomorphs. To explore whether this lack organization previously studied could attributable low acuity,...
Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects brain function of offspring when they are adult remains primarily unknown. In present work, chronic immobilization pregnant mice affected fetal growth development. When pups born from stressed were reared an environment identical that nonstressed controls, several physiological parameters essentially unaltered. However, spatial learning memory was significantly...
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included this study were 31 mood episodes 26 BD patients, and 18 controls. Circadian evaluated at admission, 2-week intervals during hospitalization, discharge. All participants wore wrist actigraphs the studies. Saliva buccal cells obtained 8:00, 11:00, 15:00, 19:00, 23:00 for two consecutive days. Collected saliva used analysis cortisol gene rhythm, respectively. had different phases acute...
Circadian rhythms, biological oscillations with a period of about 24 h, are maintained by genetically determined innate time-keeping system called the molecular circadian clockwork. Despite physiological and clinical importance clock, development small molecule modulators that directly target core clock machinery has only been recently initiated. In present study, we aimed to identify novel influencing feedback loop applying our two-step cell-based screening strategy based on E-box-mediated...
It is well established that stress in early life can alter the activity of hypothalamus-pituitary-adrenal (HPA) axis, but most studies to date have focused on HPA reactivity response a single acute stress. The present study addressed whether pregnant mice could influence adaptive responses their offspring chronic Male were exclusively used this study. Elevated plus maze tests revealed 14 d repeated restraint (6 h per day; from postnatal 50-63) significantly increased anxiety-like behavior...
Abstract Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune inflammatory responses, various brain functions. During stress GCs are secreted through activation the hypothalamic–pituitary–adrenal axis, whereas circulating GC levels in unstressed states follow robust circadian oscillation with peak around onset active period day. A recent advance chronobiological research has revealed that multiple...
In the cerebral cortex of mammals, horizontal connections link cells up to several millimeters apart. primary visual (V1) mammals with orientation maps, ramify in periodic patches across cortical surface, connecting similar preferences. Rodents have orientation-selective but lack raising questions about relationships functional maps and receptive field properties. To address these questions, we studied anatomy characterized interactions V1 gray squirrel, a highly rodent. Long-range intrinsic...
The environment in early life elicits profound effects on fetal brain development that can extend into adulthood. However, the long-lasting impact of maternal stress emotional learning remains largely unknown. Here, we focus amygdala-related processes maternally stressed mice. In these mice, fear memory consolidation and certain related signaling cascades were significantly impaired, though innate fear, acquisition, synaptic NMDA receptor expression amygdala unaltered. accordance with...