A5034194337- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
- Nitric Oxide and Endothelin Effects
- Pancreatic function and diabetes
- Protease and Inhibitor Mechanisms
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Neuroendocrine regulation and behavior
- Aldose Reductase and Taurine
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Pluripotent Stem Cells Research
- Metabolism and Genetic Disorders
- Neuroscience and Neural Engineering
University of Ulsan
2014-2023
Ulsan College
2014-2023
Korea Institute of Science and Technology
2012-2014
Korea Institute of Brain Science
2010
Inha University
2008
Cornell University
1986-2003
Chungnam National University
2001
National Institutes of Health
2000
Asan Medical Center
2000
Burke Medical Research Institute
1998-1999
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder associated with selective loss of the dopamine(DA)rgic neurons in substantia nigra pars compacta and degeneration projecting nerve fibers striatum. Because there currently no therapy that delays process, modification course by neuroprotective an important unmet clinical need. Toward this end, understanding cellular mechanisms render nigral particularly vulnerable have been subject intensive research. Increasing...
Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to cascade leading dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is main pathway responsible for cellular defense system against stress. a transcription factor regulates environmental response by inducing expression antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited broad range activities in HO-1, whose gene...
Microglial activation and inflammation are associated with progressive neuronal apoptosis in neurodegenerative human brain disorders. We sought to investigate molecular signaling mechanisms that govern of microglia apoptotic degeneration. report here the active form matrix metalloproteinase-3 (MMP-3) was released into serum-deprived media (SDM) PC12 cells other within 2-6 h treatment cells, SDM catalytic domain recombinant MMP-3 (cMMP-3) activated primary cultures as well BV2 a mouse cell...
Glutathione functions in catalysis, metabolism, transport, and reductive processes protection of cells by destruction free radicals, reactive oxygen intermediates, other toxic compounds endogenous exogenous origin. It also as a storage transport form cysteine. Depletion glutathione (effectively accomplished inhibition its synthesis) increases sensitivity to radiation certain is value combination with therapy or chemotherapy situations which cell selectivity can be achieved. Increased...
Recent studies have demonstrated that activated microglia play an important role in dopamine (DA) neuronal degeneration Parkinson disease (PD) by generating NADPH-oxidase (NADPHO)-derived superoxide. However, the molecular mechanisms underlie microglial activation DA cell death are still disputed. We report here matrix metalloproteinase-3 (MMP-3) was newly induced and stressed cells, active form of MMP-3 (actMMP-3) released into medium. The actMMP-3, as well catalytically recombinant...
Parkinson9s disease (PD) is a progressive neurodegenerative disorder with selective loss of dopaminergic neurons in the substantia nigra. Evidence suggests oxidation dopamine (DA) to DA quinone and consequent oxidative stress as major factor contributing this vulnerability. We have previously observed that exposure or induction NAD(P)H:quinone reductase (QR1), enzyme catalyzes reduction quinone, effectively protects cells. Sulforaphane (SF) drug identified potent inducer QR1 various...
Abstract We have previously demonstrated that the active form of matrix metalloproteinase‐3 (actMMP‐3) is released from dopamine(DA)rgic neurons undergoing apoptosis. Herein, whether actMMP‐3 might be generated intracellularly, and if so, it involved in apoptosis DArgic itself was investigated primary cultured wild‐type, MMP‐3 knockout animals, CATH.a cells. During apoptosis, gene expression induced, specifically among various classes MMPs, generating proform (55 kDa) which subsequently...
Voluntary exercise is known to have an antidepressant effect. However, the underlying mechanism for this action of remains unclear, and little progress has been made in identifying genes that are directly involved. We identified macrophage migration inhibitory factor (MIF) by analyzing existing mRNA microarray data confirmed augmented expression selected under two experimental conditions: voluntary electroconvulsive seizure. A proinflammatory cytokine, MIF expressed central nervous system...
BACKGROUND: The inhibition of neuronal activity by electrical deep brain stimulation is one the mechanisms explaining therapeutic effects in patients with Parkinson disease (PD) but cannot specifically activate or inactivate different types neurons. Recently, a new technology based on optogenetics has been developed to modulate specific However, optical inactivation subthalamic nucleus (STN) have not fully investigated. OBJECTIVE: To perform various behavioral tests evaluate changes motor...
This study examined whether ethyl pyruvate (EP) promotes the survival of nigrostriatal dopaminergic (DA) neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Parkinson's disease. MPTP induced degeneration DA and glial activation as visualized by tyrosine hydroxylase, macrophage Ag complex-1, and/or fibrillary acidic protein immunoreactivity. Western blotting immunohistochemistry showed microglial NADPH oxidase astroglial myeloperoxidase (MPO) subsequent reactive oxygen...
The neurotransmitter serotonin is involved in a variety of brain functions, and abnormal changes neurotransmission are associated with an array psychiatric disorders, including depression. Sertraline selective reuptake inhibitor (SSRI) effective antidepressant. increases the concentration synaptic cleft by short-term action; however, clinical improvement observed only after several weeks, suggesting that therapeutic effect may be caused long-term alterations transmission. We determined...
Abstract Parkinson's disease is a neurodegenerative disorder associated with selective loss of dopaminergic neurons in the substantia nigra. While underlying cause this cell death poorly understood, oxidative stress thought to play role. We have previously shown that tetrahydrobiopterin (BH4), an obligatory co‐factor for tyrosine hydroxylase (TH), exerts toxicity on dopamine‐producing cells and prevented by antioxidants. This study shows BH4‐induced primarily mediated dopamine, evidenced...
Oxidative stress is believed to contribute the pathophysiology of Parkinson's disease, in which nigrostriatal dopaminergic (DA) neurons undergo degeneration. Identification endogenous molecules that generation oxidative and vulnerability these cells critical understanding etiology this disease. Exposure tetrahydrobiopterin (BH4), obligatory cofactor for DA synthesis, was observed previously cause damage cells. To demonstrate physiological relevance observation, we investigated whether an...
Background and Purpose Neuroinflammation through microglial activation is involved in the pathogenesis of neurodegenerative diseases including P arkinson's disease ( PD ), a major disorder characterized by dopaminergic neuronal death substantia nigra. We examined our novel synthetic compound VSC 2 for its anti‐inflammatory properties towards development therapy. Experimental Approach tested effects on production various NF‐κB ‐dependent proinflammatory molecules N rf2‐dependent antioxidant...
The underlying cause of the selective death nigral dopaminergic neurons in Parkinson9s disease is not fully understood. Tetrahydrobiopterin (BH4) synthesized exclusively monoaminergic, including dopaminergic, cells and serves as an endogenous obligatory cofactor for syntheses dopamine nitric oxide. Because BH4 contributes to these two potential oxidative stressors also undergoes autoxidation, thereby producing reactive oxygen species, it was possible that may play a role vulnerability cells....
Background. Endothelial cells are active participants in the processes controlling coagulation, inflammation and immune response. Variations recognized between endothelia isolated from different vascular beds as well species. Though transforming growth factor‐β1 (TGF‐β1) has been known to have an anti‐inflammatory action, little is about its effect on expression of cellular adhesion molecules during inflammatory process human glomerular endothelial cells. The aim this study was determine...
The first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis is GTP cyclohydrolase (GTPCH). BH4 serves as the essential cofactor for aromatic L-amino acid hydroxylases, such tyrosine hydroxylase (TH) tryptophan (TPH), well nitric oxide synthase (NOS). We hypothesized that to provide access cofactor, a close association exists between BH4-synthesizing BH4-dependent enzymes, we determined relationship among GTPCH, neuronal NOS (nNOS), TH rat brain adrenal gland using...