A5019091283- Photoreceptor and optogenetics research
- Ion Channels and Receptors
- Immune cells in cancer
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Immune Response and Inflammation
- GABA and Rice Research
- Nutrition, Genetics, and Disease
- Cancer Immunotherapy and Biomarkers
- Agriculture, Soil, Plant Science
- Glaucoma and retinal disorders
- Phytochemicals and Antioxidant Activities
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Neurological disorders and treatments
- Mesenchymal stem cell research
- Thyroid Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Lung Cancer Research Studies
- Tryptophan and brain disorders
- CRISPR and Genetic Engineering
Korea Institute of Science and Technology
2012-2023
Government of the United States of America
2023
Korea Institute of Brain Science
2014-2023
Korean Association Of Science and Technology Studies
2023
Korea University of Science and Technology
2023
Bio-Medical Science (South Korea)
2023
National Cancer Institute
2023
National Institutes of Health
2023
Hoseo University
2015-2022
Gyeongsang National University
2007-2013
BACKGROUND: The inhibition of neuronal activity by electrical deep brain stimulation is one the mechanisms explaining therapeutic effects in patients with Parkinson disease (PD) but cannot specifically activate or inactivate different types neurons. Recently, a new technology based on optogenetics has been developed to modulate specific However, optical inactivation subthalamic nucleus (STN) have not fully investigated. OBJECTIVE: To perform various behavioral tests evaluate changes motor...
Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Jin Young Bae, Heeyoung An, Seahyung Park, Soo-Jin Oh, Eunju Kim, Eunmi Hwang, Yong Chul Bae and C. Justin Lee. Exp Neurobiol 2018;27:120-8. https://doi.org/10.5607/en.2018.27.2.120
Abstract Low-pathogenicity avian influenza H9N2 remains an endemic disease worldwide despite continuous vaccination, indicating the need for improved vaccine strategy. Bacillus subtilis ( B. ), a gram-positive and endospore-forming bacterium, is non-pathogenic species that has been used in probiotic formulations both animals humans. The objective of present study was to elucidate effect spores as adjuvants chickens administered inactivated virus H9N2. Herein, adjuvanticity demonstrated by...
Trabecular meshwork (TM) cells are phagocytic that employ mechanotransduction to actively regulate intraocular pressure. Similar macrophages, they express scavenger receptors and participate in antigen presentation within the immunosuppressive milieu of anterior eye. Changes pressure deform compress TM, altering their control aqueous humor outflow but it is not known whether transducer activation shapes temporal signaling. The present study combines electrophysiology, histochemistry...
<b><i>Background:</i></b> The inhibition of neuronal activity by electrical deep brain stimulation is one the mechanisms explaining amelioration levodopa-induced dyskinesia. However, cannot specifically activate or inactivate selected types neurons. <b><i>Objectives:</i></b> We applied optogenetics as an alternative treatment to for dyskinesia, and also confirm that mechanism dyskinesia subthalamic nucleus mediated through inhibition....
Background: Imiquimod (IQ) is known as an agonist of Toll-like receptor 7 (TLR7) and widely used to treat various infectious skin diseases. However, it causes severe itching sensation its side effect. The precise mechanism how IQ unknown. A recent report suggested a molecular target TLR7 expressed in dorsal root ganglion (DRG) neurons. we recently proposed TLR7-independent mechanism, which the activation not required for action DRG To resolve this controversy regarding involvement address...
Abstract: Recent studies have shown that keratinocytes can sense temperature via thermo‐transient receptor potential (TRP) channels. It is not known whether other thermosensitive ion channels such as TREK‐1, TREK‐2 and TRAAK (TREKs/TRAAK) are members of the two‐pore domain K + (K 2P ) channel family expressed in human keratinocytes. Here, we identified expression TREKs/TRAAK keratinocytes‐derived cell line HaCaT cells using RT‐PCR, immunocytochemistry, Western blot analysis patch‐clamp...
Reactive oxygen species (ROS) are key regulators of the proliferation, metastasis, and drug resistance melanoma, which accounts for 60% skin cancer deaths. In a previous study, we developed Dudleya brittonii water extract (DBWE) with antioxidant activity, but mechanism action bioactive substances DBWE have not been fully identified. This study showed altered NADPH oxidase 2 (NOX2) expression selective inhibition cytosolic ROS mitochondrial in B16-F10 melanoma cells, suggesting NOX2...
Heart disease, breast cancer, osteoporosis, depression, and autoimmune disease have been reported to be five women' s diseases that threaten health: i) heart which is the number one health risk women caused by genetic influences, age, smoking, hypertension, diabetes, obesity, ii) cancer has known result from factor, precocious puberty, late menopause, alcohol, iii) osteoporosis sex hormone unbalance, excessive diet, glucocorticoids, anticonvulsants, iv) depression due psychological factors,...
Anaplastic thyroid cancer (ATC) is highly aggressive and has very limited treatment options. Recent studies suggest that stem cell (CSC) activity in ATC could underlie this recurrence resistance to treatment. The recent approval by the U.S. Food Drug Administration of combined BRAF MEK inhibitors for patients shown some efficacy harboring
The demand for measures to improve disease resistance and productivity of livestock are increasing, as most countries prohibit the addition antibiotics feed. This study therefore aimed uncover functional feed additives help enhance immunity resistance, using Acanthopanax sessiliflorus fruit extract (ASF).ASF was extracted with 70% EtOH, total polyphenolic catechin contents were measured by Folin-Ciocalteu vanillin assay, respectively. 3D4/31 porcine macrophage cells (MΦ) activated Phorbol...
As cerebellar granule cells (GCs) coordinate the formation of regular networks during postnatal development, molecules in GCs are expected to be involved. Here, we test effects knockdown (KD) multiple epidermal growth factor-like domains protein 11 (MEGF11), which is a homolog proteins mediating astrocytic phagocytosis but substantially increased at later developmental stages on development. MEGF11-KD developing mice results abnormal structures, including extensively ectopic Purkinje cell...
The development of anuria after appendectomy is usually related to complications associated with appendicitis or the surgical sequelae appendectomy. We report an unusual case in a 20-year-old woman. patient was transferred our hospital due sudden cessation urine output just initially suspected that caused by complication surgery. However, review her medical history and abdominal computed tomography (CT) scan revealed distal ureteral stone single kidney had anuria. There are few cases...
Cells can resist and even recover from stress induced by acute hypoxia, whereas chronic hypoxia often leads to irreversible damage eventually death. Although little is known about the response(s) in neuronal cells, alterations ion channel activity could be preferential. This study aimed elucidate which type involved response rat pheochromocytomal (PC12) cells as a cell model. Using perfusing solution saturated with 95% N2 5% CO2, induction of was confirmed based on increased intracellular...
Abstract Introduction: Overexpression of somatostatin receptors (SSTRs), particularly SSTR2, is found in gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and subsets other solid such as small-cell lung cancer (SCLC). β-emitting radiopharmaceutical therapy Lu-177 DOTATATE has been approved for SSTR-expressing (SSTR+) GEP-NETs, but the relatively low objective response rate frequent post-treatment progression represent an unmet medical need. Based on preliminary clinical anti-tumor...
Objectives This study aimed to explore the experiences of psychiatric nurses who were quarantined in cohorts prevent spread infection during COVID-19 pandemic. Methods Data collected from July 19 December 28, 2021 through in-depth interviews with cohort isolation for more than 3 weeks until data was saturated snowball sampling method. Through one-on-one nurses, meaning analyzed according into themes, sub-themes, and categorization stages Colaizzi's phenomenological Results The experience...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Toll-like receptors (TLRs), as a part of innate immunity, plays an important role in detecting pathogenic molecular patterns (PAMPs) which are structural components or product pathogens and initiate host defense systems immunity. Precise negative feedback regulations TLR signaling maintaining homeostasis to prevent tissue damage by uncontrolled inflammation during immune responses. In this study, we identified characterized the function pancreatic progenitor cell differentiation...