A5101760141- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- Ion Channels and Receptors
- Ubiquitin and proteasome pathways
- Cardiac electrophysiology and arrhythmias
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Plant Stress Responses and Tolerance
- Connexins and lens biology
- Heat shock proteins research
- Protein Tyrosine Phosphatases
- Genetics and Neurodevelopmental Disorders
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Photosynthetic Processes and Mechanisms
- Advanced Glycation End Products research
- Peptidase Inhibition and Analysis
- 14-3-3 protein interactions
- Erythrocyte Function and Pathophysiology
- Skin and Cellular Biology Research
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
Gyeongsang National University
2009-2022
Korea Advanced Institute of Science and Technology
2017-2019
Korea University
2016-2017
The Ohio State University
2014
Seoul National University
2002-2007
State University of New York
2007
Stony Brook University
2006-2007
Gwangju Institute of Science and Technology
1997
Abstract Chitinase 3‐like 1 (CHI3L1) is a secreted glycoprotein that has pleiotropic activity in aggressive cancers. In our study, we examined the expression and function of CHI3L1 glioma cells. was highly expressed human tissue, whereas its normal brain tissue very low. suppression by shRNA reduced cell invasion, anchorage‐independent growth increased death triggered several anticancer drugs, including cisplatin, etoposide doxorubicin, overexpression had opposite effect Because invasive...
The role of IKCa in cardiac repolarization remains controversial and varies across species. relevance the current as a therapeutic target is therefore undefined. We examined cellular electrophysiologic effects blockade controls, chronic heart failure (HF) HF with sustained atrial fibrillation. used perforated patch action potential recordings to maintain intrinsic calcium cycling. blocker (apamin 100 nM) was examine ventricular myocytes. A canine tachypacing induced model (1 4 months, n = 5...
Nek2 is a mitotic kinase whose activity varies during the cell cycle. It well known that involved in centrosome splitting, and number of studies have indicated crucial for maintaining integrity centrosomal structure microtubule nucleation activity. In present study, we report NIP2, previously identified as centrobin, novel substrate Nek2. NIP2 was daughter-centriole-specific, but also found association with stable network cytoplasm. Ectopic formed aggregates dissolved by into small pieces...
Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms various cell types. The pro-apoptotic CLU appears to be nuclear isoform (nuclear clusterin; nCLU), and the secretory (sCLU) thought anti-apoptotic. detailed molecular mechanism of nCLU as molecule has not yet been clear. In current study, overexpressed induced apoptosis human kidney cells. Biochemical studies revealed that sequestered Bcl-XL via putative BH3 motif C-terminal coiled coil...
A non-steroidal anti-inflammatory drug (NSAID) has many adverse effects including cardiovascular (CV) risk. Diclofenac among the nonselective NSAIDs highest CV risk such as congestive heart failure, which resulted commonly from impaired cardiac pumping due to a disrupted excitation-contraction (E-C) coupling. We investigated of diclofenac on L-type calcium channels are essential E-C coupling at level single ventricular myocytes isolated neonatal rat heart, using whole-cell voltage-clamp...
Mitochondrial trans-2-enoyl-CoA reductase (MECR) is involved in mitochondrial synthesis of fatty acids and highly expressed mitochondria. MECR also known as nuclear receptor binding factor-1, which was originally reported with yeast two-hybrid screening a protein the hormone peroxisome proliferator-activated α (PPARα). However, PPARα are localized at different compartment, mitochondria, nucleus, respectively. Therefore, presence cytosolic or isoform necessary for functional interaction...
TRPM4 channels are Ca2+-activated nonselective cation which deeply involved in physiological and pathological conditions. However, their trafficking mechanism binding partners still elusive.We have found the 14-3-3γ as a partner for TRPM4b using its N-terminal fragment from yeast-two hybrid screening. Ser88 at N-terminus of is critical by showing GST pull-down co-immunoprecipitation. Heterologous overexpression HEK293T cells increased expression on plasma membrane was measured whole-cell...
Copine 1 (CPNE1) is a calciumdependent phospholipid protein that has been shown to regulate the AKT serine/threonine kinase (AKT) signaling pathway mediate its function in various cell types. However, little known about physiological of this breast cancer cells. We aimed investigate prognostic and therapeutic value CPNE1 erb-b2 receptor tyrosine 2 [human epidermal growth factor (HER2)]-positive luminal A subtypes cancer.Western blotting, viability, wound-healing invasion assays were...
Although melanogenesis is a defense mechanism against ultraviolet (UV)-induced skin damage, abnormally excessive melanin production causes pigmentation disorders. Tyrosinase, as key factor for synthesis, plays an important role in inducing pigmentation. Therefore, the inhibition of tyrosinase crucial preventing cosmetics and medicine fields. However, majority well-known inhibitors have been discontinued due to toxic effects on or lack selectivity and/or stability. In this study, we evaluated...