A5102984031- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- Nuclear Receptors and Signaling
- Protease and Inhibitor Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Tryptophan and brain disorders
- Biochemical and biochemical processes
- Sulfur Compounds in Biology
- interferon and immune responses
- Synthesis and Reactions of Organic Compounds
- Coenzyme Q10 studies and effects
- Photoreceptor and optogenetics research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Neuroscience and Neuropharmacology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Signaling Pathways in Disease
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- Eicosanoids and Hypertension Pharmacology
- Free Radicals and Antioxidants
- Bioactive Compounds and Antitumor Agents
Kyung Hee University
2024
University of Ulsan
2012-2021
Ulsan College
2012-2021
Korea University Medical Center
2017
Pukyong National University
2016
Background and Purpose Neuroinflammation through microglial activation is involved in the pathogenesis of neurodegenerative diseases including P arkinson's disease ( PD ), a major disorder characterized by dopaminergic neuronal death substantia nigra. We examined our novel synthetic compound VSC 2 for its anti‐inflammatory properties towards development therapy. Experimental Approach tested effects on production various NF‐κB ‐dependent proinflammatory molecules N rf2‐dependent antioxidant...
The anti-oxidant enzyme heme oxygenase-1 (HO-1) is known to exert anti-inflammatory effects. From a library of pyrazolo[3,4-
BACKGROUND AND PURPOSE In Parkinson's disease, the dopaminergic neurones in substantia nigra undergo degeneration. While exact mechanism for degeneration is not completely understood, neuronal apoptosis and neuroinflammation are thought to be key contributors. We have recently established that MMP‐3 plays crucial roles cell death microglial activation. EXPERIMENTAL APPROACH tested effects of 7‐hydroxy‐6‐methoxy‐2‐propionyl‐1,2,3,4‐tetrahydroisoquinoline (PTIQ) on expression inflammatory...
Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters brain, exerts neuroprotective effect, and inhibits NFκB activation. To further assess utility as potential therapeutic agent for PD, we tested whether anti-inflammatory effect
The degenerative process of the nigral dopamine(DA)rgic neurons in Parkinson's disease (PD) involves both oxidative stress and neuroinflammation. In present study, we aimed at developing a novel antioxidant anti-inflammatory agent for PD therapy. Toward this end, screened focused library isothiocyanate derivatives that have generated an property. We obtained compound ITC-57 found effectively induced gene expression enzymes NAD(P)H quinone oxidoreductase-1, catalytic modulatory subunits...
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and associated motor deficits, suggesting neuroprotective therapeutic utility for Parkinson's disease. Microglia are closely with neuroinflammation, which plays key role in pathogenesis neurodegenerative diseases. In this study, we investigated effects on signaling involving AMP-activated protein kinase (AMPK) heme oxygenase-1 (HO-1), enzymes thought to regulate...
Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation oxidative stress are believed to be involved in its pathogenesis. In present study, we provide data that synthetic steroid exemestane, which currently being used treat breast cancer, may useful for PD therapy. BV-2 microglial cells, exemestane activated transcription factor Nrf2 induced expression Nrf2-dependent genes encode antioxidant...
76 Background: Arsenic trioxide (ATO) is known to inhibit epithelial-mesenchymal transition (EMT) in hepatolocellular carcinoma and breast cancer cells, however, little has been reported gastric cells. In this study, we aimed investigate the mechanism of ATO signal transducer activator transcription 3 (STAT3) activity EMT Methods: We performed wound closure assay Matrigel invasion for functional studies EMT, western blot measurement protein markers using AGS Results: Compared with control, 5...