KMS99220 Exerts Anti-Inflammatory Effects, Activates the Nrf2 Signaling and Interferes with IKK, JNK and p38 MAPK via HO-1.

• DOI: 10.14348/molcells.2019.0129
• Publication Date: 2019-10-31
• Authors: Ji Ae Lee; Dong Jin Kim; Onyou Hwang
• Keywords: 0301 basic medicine; Male; NF-E2-Related Factor 2; Dopaminergic Neurons; Morpholines; Anti-Inflammatory Agents; JNK Mitogen-Activated Protein Kinases; Articles; Models, Biological; p38 Mitogen-Activated Protein Kinases; I-kappa B Kinase; Mice, Inbred C57BL; 03 medical and health sciences; Mice; Chalcones; Animals; Microglia; Heme Oxygenase-1; Signal Transduction

Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters brain, exerts neuroprotective effect, and inhibits NFκB activation. To further assess utility as potential therapeutic agent for PD, we tested whether anti-inflammatory effect