A5075673227- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Advanced Nanomaterials in Catalysis
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Covalent Organic Framework Applications
- Chronic Lymphocytic Leukemia Research
- Sympathectomy and Hyperhidrosis Treatments
- Streptococcal Infections and Treatments
- HIV Research and Treatment
- Advanced Breast Cancer Therapies
- Inflammatory Biomarkers in Disease Prognosis
- Drug Solubulity and Delivery Systems
- Dental Anxiety and Anesthesia Techniques
- Trigeminal Neuralgia and Treatments
- Laser Applications in Dentistry and Medicine
- Venous Thromboembolism Diagnosis and Management
- Advanced Drug Delivery Systems
- Metabolomics and Mass Spectrometry Studies
- Sulfur Compounds in Biology
- Analytical Chemistry and Sensors
- Peptidase Inhibition and Analysis
Jinan University
2025
University of Science and Technology of China
2021-2024
Southwest University of Science and Technology
2022-2024
Harvard University
2023
Guangxi Medical University
2015-2023
Changchun Institute of Applied Chemistry
2021-2022
Chinese Academy of Sciences
2009-2022
Capital Medical University
2018-2021
Beijing Ditan Hospital
2021
Central South University
2019
The high glutathione (GSH) content in tumor cells strongly affects the efficiency of chemodynamic therapy (CDT). Despite devoted efforts, it still remains a formidable challenge for manufacturing tumor-specific CDT with rapid and thorough depletion GSH. Herein, multistage GSH-consuming is presented. By consuming reserved GSH inhibiting both raw materials energy supply synthesis cancer cells, achieves highly potent exhaustion. Our used glycolysis inhibitor cuts off specific to increase...
Abstract Gliomas are common and refractory primary tumors closely associated with the fine structures of brain. Photothermal therapy (PTT) has recently shown promise as an effective treatment for gliomas. However, nonspecific accumulation photothermal agents may affect adjacent normal brain structures, inflammatory response induced during PTT result in increased risk tumor recurrence or metastasis. Here, design fabrication intelligent nanomachine is reported based on Gd 2 O 3 @Ir/TMB‐RVG29...
Abstract Computer‐aided prediction of rodent carcinogenicity for the external test set consisting 293 chemicals was performed by PASS (Prediction Activity Spectra Substances) and CISOC‐PSCT. The included 64 carcinogens from ISS Carcinogens Data Bank 229 noncarcinogens Prestwick Chemical Library. We calculated accuracy CISOC‐PSCT in apart, two programs together (the consensus model). Sensitivity, specificity (concordance) were (0.81, 0.74, 0.76), (0.36, 0.89, 0.77) model (0.69, 0.86, 0.83)....
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
Aim: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in bloodstream infection (BSI) deserves further investigation. Patients & methods: NLR values were measured and compared BSI patients healthy controls. receiver operating characteristic cut-off subgroups. Results: We have the study group with 2160 normal 2523 controls, which was significantly high (11.36 ± 21.38 vs 2.53 0.86; p < 0.001) area under curve 0.834 (95% CI: 0.825–0.842; 0.001). critical value for diagnosis 3.09, a...
In China, HIV-1-infected patients typically receive antiretroviral therapy (ART) that includes lamivudine (3TC) as a reverse-transcriptase inhibitor (RTI) (ART-3TC). Previous studies from certain developed countries have shown that, in ART-3TC, 3TC-resistant HBV progressively emerges at an annual rate of 15–20% coinfected with HIV-1 and HBV. This scenario China warrants investigation because >10% all HIV-infected are carriers. We measured the occurrence during ART-3TC for HIV-HBV coinfection...
Objective Xuebijing injection (XBJ) is a commonly used herbal medicine in China. However, the physical compatibility of XBJ with other intravenous drugs remains unclear. The purpose this research to evaluate 53 (including 31 Chinese injections and 22 chemicals) during simulated Y-site administration. Methods administration was vitro by admixing 0.33 ml/ml an equal volume diluted drugs, respectively. Physical including visual inspection, Tyndall beam, particle limits, turbidity, pH,...
To present a model of extended home nursing support provided through WeChat for pediatric colostomy patients between the first and second surgery to parents assist them in possible complications at home, reduce caused by improper care, improve quality life ensure success recovery surgery. A combination relevant clinical information, health care guidelines, training as well establishment specific monitoring protocol was during patient's hospitalization. system established with regular...
Abstract Background Thermage is a monopolar radiofrequency (RF). It has become an indispensable part of facial and body youthful methods. Although the current device constantly improving in epidermal cooling techniques even automatically measures local impedance value, applying surface anesthesia can take some pain away caused by thermage, patient's severe jaw neck areas still difficult to resolve. Methods The author describes how he uses combination buccal nerve block (BNB) superficial...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Abstract A method combining chemical and biological experiments computer‐aided molecular design was used to optimize lead compounds with inhibiting activity against Sphaerotheca fuliginea. 44 propiophenone oxime derivatives were synthesized by 3‐amino‐1‐arylpropan‐1‐one halohydrocarbon. The results of test showed that most these had QSAR study done based on the experimental data compounds. CoMFA ( r CV 2 , S are 0.577, 0.258 0.962, respectively) CoMSIA 0.583, 0.343 0.932 models contributed...
Resistance to endocrine treatment and CDK4/6 inhibitors (CDK4/6i) is a major clinical challenge in estrogen receptor (ER) positive (ER+) breast cancer (BC). Previously, we identified cyclin-dependent kinase 7 (CDK7) as an essential gene ER mutant BC models showed that CDK7 silencing suppressed mutant-dependent cell growth. Selective (CDK7i) are currently development for the of ER+ BC. However, since has diverse roles biology, it critical decipher which functions govern anti-tumor activity...