A5058779006- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Sleep and related disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Autoimmune Neurological Disorders and Treatments
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Cholinesterase and Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Calpain Protease Function and Regulation
Fudan University
2016-2025
Zhongshan Hospital
2017-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023-2025
State Key Laboratory of Medical Neurobiology
2014-2024
Zhongnan Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
ShanghaiTech University
2018-2023
Anhui Medical University
2021-2023
Huashan Hospital
2022-2023
Beijing Institute of Neurosurgery
2023
Abstract Reduced food intake is common to many pathological conditions, such as infection and toxin exposure. However, cortical circuits that mediate feeding responses these threats are less investigated. The anterior insular cortex (aIC) a core region integrates interoceptive states emotional awareness consequently guides behavioral responses. Here, we demonstrate the right-side aIC CamKII + (aIC ) neurons in mice activated by aversive visceral signals. Hyperactivation of attenuates...
The lateral hypothalamus (LH) is physiologically critical in brain functions. LH also plays an important role drug addiction. However, neural circuits underlying involvement of addiction remain obscure. In the present study,our results showed that male mice, during context-induced expression morphine withdrawal memory, glutamatergic neurons played role; dopamine D1 receptor-expressing medium spiny (D1-MSNs) projecting from core nucleus accumbens (NAcC) to were upstream circuit activate...
Abstract Patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, often present severe psychiatric symptoms, yet the neuropathological mechanisms underlying their cognitive deficits remain insufficiently understood. In this study, we constructed an animal model using anti-NMDAR IgG purified from serum of patients and used obtained healthy individuals as a control. Daily administration into medial prefrontal cortex (mPFC) mice for 7 days resulted in impairments resembling...
Background MicroRNAs (miRNAs) have been demonstrated playing important roles in the procession of prostate cancer cells transformation from androgen-dependence to androgen-independence. Methods We conducted miRNA microarray and realtime PCR analyses both androgen-dependent (ADPC) androgen-independent (AIPC) tissues. also explored role hsa-miR-146a-5p (miR-146a) MSKCC clinical database. Moreover, impact miR-146a on apoptosis were detected by Hoechst staining fluorescence-activated cell sorter...
One reported mechanism for morphine activation of dopamine (DA) neurons the ventral tegmental area (VTA) is disinhibition model VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts balance between and excitatory input to in favor excitation then leads neuron excitation. However, it not known whether has an additional strengthening effect on input. Our results suggest that glutamatergic inhibited by GABAergic interneurons via GABAB receptors promotes presynaptic glutamate...
Objects displaced intermittently across the visual field will nonetheless give an illusion of continuous motion [called apparent (AM)] under many common conditions. It is believed that form perception minor importance in determining AM, and AM mediated by motion-sensitive areas "where" pathway cortex. However, typically interact specific ways when natural objects move through environment. We used functional magnetic resonance imaging to measure cortical activation long-range compared...
Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations human IgLON5 antibodies have suggested an antibody-mediated pathogenesis, but whether can induce symptoms in mice yet to be shown. Moreover, effects of anti-IgLON5 on neurons and precise molecular mechanisms vivo remain controversial.We investigated evaluated their long-term effects. We used two independent passive-transfer animal...
Itch is an unpleasant sensation that initiates scratching behavior. The itch–scratch reaction a complex phenomenon implicates supraspinal structures required for regulation of sensory, emotional, cognitive, and motivational aspects. However, the central mechanisms underlying processing itch interplay regions spinal cord in regulating processes are poorly understood. Here, we have shown neural projections from anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) constitute critical...
An important reasons for drug relapse is the retrieval of withdrawal memory induced by conditioned context. Previous studies have suggested that basolateral amygdala (BLA) plays an role in context-induced morphine memory. However, downstream neuronal circuits activation BLA remain unknown. Using retrograde labeling, immunohistochemical, and optogenetic approaches, we found that, although neurons projecting to prelimbic cortex (PrL) played memory, they do not exhibit increased expression...
Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study morphine-induced adaptation in and its functional significance importance to understand mechanism morphine addiction. Previous studies have found number adaptive changes at molecular levels brain. A from our lab showed that increases expression D1 receptors presynaptic terminals coming other structures basolateral amygdala (BLA) played an important role environmental cue-induced retrieval...
Growing incidence of postoperative cognitive dysfunction (POCD) in the elderly populations after major surgery challenges us to provide stable and effective treatments. Mitochondria is essential pathogenesis aging neurodegenerative diseases. It hypothesized that varenicline improves impairment through restoring mitophagy tau phosphorylation. Wild type C57BL/6 mice (male, 18-month-old) were subjected laparotomy with or without chronic administration. Postoperative cognition anxiety determined...
The combination of antiapoptotic and angiogenic actions may represent a pharmacotherapeutic strategy for the treatment myocardial infarction. Fibroblast growth factor (FGF) is expressed in various cell types including endothelial muscle cells promotes their survival, migration, proliferation.Myocardial microvascular were divided into four groups, sham, hypoxia, basic FGF (bFGF), bFGF plus 2-methoxyestradiol subjected to vitro apoptotic analysis Matrigel assays. An vivo model infarction was...
A longed lack of control over harmful stimuli can lead to learned helplessness (LH), a significant factor in depression. However, the cellular and molecular mechanisms underlying LH, eventually behavioral despair, remain largely unknown. The deleted colorectal cancer (dcc) gene is associated with risk therapeutic potential regulation mechanism DCC despair are still uncertain. In this study, we showed that depressive stimulators, including lipopolysaccharide, unpredictable chronic mild...
Dopaminergic signaling in the basolateral amygdala (BLA) is important for drug-stimulus learning that triggers relapse to drug-seeking behavior. However, little known about adaptive changes this pathway upon chronic morphine treatment. In paper, we observed influence of treatment on effect dopamine (DA) excitatory transmission pyramidal cells BLA slices with whole-cell patch-clamp method. We also studied its mechanism and significance pharmacological approaches combined biochemical...
Background: mast cells play an important role in airway inflammation asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed primary human lung and plays a critical for cell survival. This study aimed to investigate the of TRPM7 on degranulation release cytokines rat bone marrow-derived (BMMCs). Methods: expression levels were observed by immunocytochemistry RT-PCR between normal asthmatic BMMCs. TRPM7-specific shRNA 2-aminoethoxydiphenyl borate (2-APB)...