A5032839141- Autoimmune Neurological Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Atmospheric chemistry and aerosols
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Air Quality and Health Impacts
- Assisted Reproductive Technology and Twin Pregnancy
- Catalytic Alkyne Reactions
- Organometallic Complex Synthesis and Catalysis
- Case Reports on Hematomas
- COVID-19 and Mental Health
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nuclear Receptors and Signaling
- Aerodynamics and Fluid Dynamics Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Aerospace Engineering and Control Systems
- Amyotrophic Lateral Sclerosis Research
- Myasthenia Gravis and Thymoma
- Pharmacology and Obesity Treatment
- Ocean Acidification Effects and Responses
- Marine and coastal ecosystems
- Venous Thromboembolism Diagnosis and Management
- Multiple Sclerosis Research Studies
Southern Medical University
2022-2025
Shanghai Sixth People's Hospital
2023-2024
Shanghai Jiao Tong University
2020-2024
East China Normal University
2023-2024
Hangzhou Normal University
2024
Institute of Modern Physics
2024
Fudan University
2024
Xi'an Aeronautical University
2022-2024
Ruijin Hospital
2020-2023
Shanghai Mental Health Center
2020-2023
Abstract Background Atherogenic index of plasma (AIP), a marker atherosclerosis and cardiovascular disease (CVD). However, few studies have investigated association between AIP all-cause mortality specific-mortality in the general population. Methods This study included data from 14,063 American adults. The exposure variable was AIP, which defined as log10 (triglycerides/high-density lipoprotein cholesterol). outcome variables specific-mortality. Survey-weighted cox regressions were...
Abstract. Ambient polycyclic aromatic hydrocarbons (PAHs) and their derivatives have severe adverse impacts on organism health ecosystem safety. However, global distributions, sources, fate in marine aerosols remain poorly understood. To fill the knowledge gap, high-volume air samples were collected along a transect from China to Antarctica analyzed for particulate PAHs derivatives. The highest PAH concentrations observed Western Pacific (WP: 447±228 pg/m³), followed by East Sea (ECS: 195...
Background Cardiovascular disease (CVD) remains a major health concern globally, contributing to considerable burden. However, few studies have considered long-term cumulative blood pressure (cBP) exposure in middle-aged and older population China. The aim of this study was investigate whether cBP associated with subsequent cardiovascular outcomes among participants without CVD at baseline Chinese over 45 years old.
Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations human IgLON5 antibodies have suggested an antibody-mediated pathogenesis, but whether can induce symptoms in mice yet to be shown. Moreover, effects of anti-IgLON5 on neurons and precise molecular mechanisms vivo remain controversial.We investigated evaluated their long-term effects. We used two independent passive-transfer animal...
Abstract Context Up to 40% of patients with polycystic ovary syndrome (PCOS) have prediabetes; an optimal pharmacotherapy regimen for diabetes prevention in PCOS is yet be established. Objective To evaluate clinical efficacy exenatide (EX), metformin (MET), or combination (COM) prediabetes PCOS. Design Randomized, open-label, parallel-group controlled trial. Setting Renji Hospital Affiliated Shanghai Jiaotong University School Medicine. Patients (fasting plasma glucose 5.6-6.9 mmol/L and/or...
Abstract Background We conducted this study to describe detailed the clinical characteristics, ancillary test results and treatment response of a group Chinese patients with anti‐IgLON5 disease. Methods recruited 13 positive IgLON5 antibodies in serum and/or cerebrospinal fluid from nine tertiary referral centers. Patients were enrolled February 2017 July 2021. retrospectively collected information on presenting main symptoms, follow‐up outcomes. Results The median age onset for symptoms was...
Early screening of cognitive function is critical to dementia treatment and care. However, traditional tests require face-to-face administration are often limited by implementation costs biases.This study aimed assess whether the Thoven Cognitive Self-Assessment (TCSA), a novel, innovative two-step touchscreen-based cognition assessment tool, could identify early impairment due in older adults.The TCSA was administered 61 healthy controls (HCs), 46 participants with mild (MCI) 44 diagnosed...
Abstract. High contents of reactive nitrogen components aggravate air pollution and could also impact ecosystem structures functioning across the terrestrial–aquatic–marine continuum. However, long-term historical trends future predictions at global scale still remain highly uncertain. In our study, field observations, satellite products, model outputs, many other covariates were integrated into multi-stage machine-learning to capture patterns during 2000–2019. order decrease estimate...
Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex race/ethnicity subgroups, as well investigate potential risk factors associated with in US adolescents.
Evidence has shown that aberrant angiogenesis is an integral part of Alzheimer's disease (AD). Angiogenesis a complex process requiring successive activation rather large series factors. The aim this study was to determine which angioge
The novel coronavirus disease 2019 (COVID-19) pandemic has given rise to fear and panic in the public. Although hospitals China reduced outpatient visits restricted inpatient admission lower risk of transmission COVID-19, this significantly affected patients need medical attention, for example, with emotional disorders.This study aimed compare beliefs towards COVID-19 among outpatients disorders (ie, anxiety or depression) those family caregivers general public examine factors that shape...
Immune checkpoint inhibitors (ICIs) are being used in patients with various advanced malignancies, and patient outcomes have improved considerably. Although ICIs can effectively treat tumors, 30-60% of experience immune-related adverse events (irAEs). Autoimmune encephalitis (AE) is a rare irAE that has become novel topic neuroimmunology received increasing attention recent years. Herein, we report case GAD65-antibody-associated AE after metastatic small cell lung cancer treatment...
Abstract Background Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level The effect of orlistat on flares in patients overweight/obesity hyperuricemia (HUA) has not been extensively studied. This study investigated effects compared to placebo overweight obese HUA. Methods A total 72 Chinese HUA were randomly divided into a group (35, 48.6%) an (37, 51.4%); trial lasted 12 weeks. primary endpoints relative changes...
The first homoleptic and heteroleptic cationic germylene-gold(I) complexes 3 , 4 7 have been synthesized structurally characterized, accompanied by the discovery of novel types π-back donations. These complexes...
Background: Anti-IgLON5 disease is a rare autoimmune of the central nervous system. It typically manifests as chronic condition, characterized by cognitive impairments, movement disorders, and sleep disorders. The mechanisms underlying disorders in this remain poorly understood due to lack research. Furthermore, exhibits both neuroimmune neurodegenerative characteristics. objective study explore caused anti-IgLON5 antibodies for first time. Methods: Antibodies were purified from serum...
Amyloid positron emission tomography (PET) can measure in-vivo demyelination in patients with multiple sclerosis (MS). However, the value of
Abstract Gibberellin (GA), auxin (IAA) and brassinosteroid (BR) are indispensable in the process of plant growth development. Currently, research on regulatory mechanism phytohormones banana dwarfism is mainly focused GA, few studies IAA BR. In this study, we measured contents endogenous BR compared transcriptomes wild-type Williams its dwarf mutant across five successive periods. We investigated relationship between hormones explored differential gene expression through transcriptome...
Since the novel coronavirus disease (COVID-19) outbreak started in late 2019, older population has accounted for a large proportion of severe and fatal cases. This study investigated mental state attitudes Chinese adults during this epidemic.Cross-sectional online surveys on convenience sample China's general at two different time points. Online were disseminated through popular social media applications. Adults 18 or living China initial (N = 1148) second stages 470) included survey. The...