A5081925414- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Retinal Imaging and Analysis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Reconstructive Surgery and Microvascular Techniques
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Kidney Stones and Urolithiasis Treatments
- Autoimmune Neurological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Head and Neck Cancer Studies
- Genetic and Kidney Cyst Diseases
- Retinal and Optic Conditions
- Ubiquitin and proteasome pathways
Hong Kong Polytechnic University
2023-2025
First Affiliated Hospital of Anhui Medical University
2013-2025
Anhui Medical University
2013-2025
Southwest Medical University
2025
Air Force Medical University
2022-2024
Sun Yat-sen University
2013-2024
Hospital of Stomatology, Sun Yat-sen University
2020-2024
Stomatology Hospital
2020-2024
Sun Yat-sen Memorial Hospital
2013-2024
Wuhan University
2024
Abstract Age-related macular degeneration (AMD) is the leading cause of central vision impairment among elderly. Effective and accurate AMD screening tools are urgently needed. Indocyanine green angiography (ICGA) a well-established technique for detecting chorioretinal diseases, but its invasive nature potential risks impede routine clinical application. Here, we innovatively developed deep-learning model capable generating realistic ICGA images from color fundus photography (CF) using...
Ferroptosis is a newly established form of regulated cell death characterized by intracellular lipid peroxidation and iron accumulation that may be promising cancer treatment strategy. However, the function therapeutic value ferroptosis in oral squamous carcinoma (OSCC) remain inadequately understood. In present study, we investigated biological role fat mass obesity-associated gene (FTO) context OSCC. We found OSCC had greater potential for ferroptosis, FTO associated with ferroptosis....
Existing automatic analysis of fundus fluorescein angiography (FFA) images faces limitations, including a predetermined set possible image classifications and being confined to text-based question-answering (QA) approaches. This study aims address these limitations by developing an end-to-end unified model that utilizes synthetic data train visual for FFA images. To achieve this, we employed ChatGPT generate 4,110,581 QA pairs large dataset, which encompassed total 654,343 from 9,392...
Clear cell renal carcinoma (ccRCC) has a high metastatic rate, and its incidence mortality are still rising. The aim of this study was to identify the key tumor-infiltrating immune cells (TIICs) affecting distant metastasis prognosis patients with ccRCC construct relevant prognostic panel predict immunotherapy response. Based on bulk RNA sequencing data, resting mast (RMCs) were screened verified using CIBERSORT algorithm, survival analysis, expression analysis. Distant metastasis-associated...
To develop and validate a deep learning model that can transform color fundus (CF) photography into corresponding venous late-phase fluorescein angiography (FFA) images.Cross-sectional study.We included 51 370 CF-venous FFA pairs 14 644 CF-late from 4438 patients for development. External testing involved 50 eyes with CF-FFA 2 public datasets diabetic retinopathy (DR) classification, 86 952 CF EyePACs, 1744 MESSIDOR2.We trained deep-learning to images. The translated images' quality was...
Abstract Prostate cancer (PCa), a severe health burden for males, accounts the second frequent and fifth tumor specific death around world. Several studies on tumor‐infiltrating immune cells (TIICs) have shown inconsistent controversial results to PCa. We downloaded gene expression matrix clinical information from TCGA, CIBERSORT was used identify proportion of TIICs. Wilcoxon's Sign Rank Test evaluated different levels in PCa normal tissues. Kaplan‐Meier curves were evaluate associations...
Epilepsy is a severe brain disorder affecting numerous patients. Recently, it inferred that modulation of microRNA-155 (miR-155) could serve as promising treatment mesial temporal lobe epilepsy (MTLE). In the current study, therapeutic potential miR-155 antagonist against TLE was evaluated and underlying mechanism involved in this regulation explored. model induced by lithium-pilocarpine method. The effect on epilepticus symptoms mice assessed using Racine classification electroencephalogram...
Abstract Background We conducted this study to describe detailed the clinical characteristics, ancillary test results and treatment response of a group Chinese patients with anti‐IgLON5 disease. Methods recruited 13 positive IgLON5 antibodies in serum and/or cerebrospinal fluid from nine tertiary referral centers. Patients were enrolled February 2017 July 2021. retrospectively collected information on presenting main symptoms, follow‐up outcomes. Results The median age onset for symptoms was...
Although translational research into autosomal dominant polycystic kidney disease (ADPKD) and its pathogenesis has made considerable progress, there is presently lack of standardized animal model for preclinical trials. In this study, we developed an orthologous mouse human ADPKD by cross-mating Pkd2 conditional-knockout mice (Pkd2f3 ) to Cre transgenic in which driven a spectrum kidney-related promoters. By systematically characterizing the model, found that Pkd2f3/f3 with transgene...
Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the PKD1 or PKD2 genes. The gene product is a Wnt cell-surface receptor. We previously showed that lack of product, PC2, increases β-catenin signaling mouse embryonic fibroblasts, renal epithelia, and isolated collecting duct cells. However, it remains unclear whether plays role phenotypes if inhibitor halt cyst formation ADPKD models. Here, using genetic pharmacologic approaches, we demonstrated elevated PC2...
Background: Autophagy, a highly conserved self-digesting process, has been deeply involved in the development and progression of oral squamous cell carcinoma (OSCC). However, prognostic value autophagy-related genes (ARGs) for OSCC still remains unclear. Our study set out to develop multigene expression signature based on ARGs individualized prognosis assessment patients. Methods: Based The Cancer Genome Atlas (TCGA) database, we identified differentially expressed prognosis-related through...
Immune checkpoint blockade (ICB) therapy has significantly improved clinical outcomes in bladder cancer. Identification of correlates benefit is critical to select appropriate for individual patients.
Fundus Autofluorescence (FAF) is a valuable imaging technique used to assess metabolic alterations in the retinal pigment epithelium (RPE) associated with various age-related and disease-related changes. The practical uses of FAF are ever-growing. This study aimed evaluate effectiveness generative deep learning (DL) model translating color fundus (CF) images into synthetic explore its potential for enhancing screening macular degeneration (AMD). . A adversarial network (GAN) was trained on...
Post-stroke depression (PSD) affects millions of patients who suffer cerebral stroke. However, the molecular mechanisms and pathophysiology are poorly understood. Previous studies have shown that exosomes been proven to be involved in neuropsychiatric disorders such as stroke post-stroke neurotransmitter release, neuronal remodeling, neuron angiogenesis. Here we extracted purified hippocampal from mouse model investigate exocytosis PSD assessed by using behavioral tests biochemical methods....
Clear cell renal carcinoma (ccRCC) is a common malignancy with high distant metastasis rate. Long non-coding RNAs (LncRNAs) are reported to be upregulated or downregulated in multiple cancers and play crucial role the of tumors prognosis. Therefore, purpose our study construct prognostic signature for ccRCC based on metastasis-related lncRNAs explore involved potential competitive endogenous RNA (ceRNA) network. The differentially expressed genes (DEGs) screened from database cancer genome...
Abstract Background Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported play crucial role progression tumors. However, its function tongue squamous cell carcinoma (TSCC) remains unclear. Methods SHMT2 expression was analyzed using samples online databases, and assessed through immunohistochemistry staining collected clinical specimens. The correlation between cycle predicted...