A5101632521- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Sexual function and dysfunction studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Hormonal and reproductive studies
- Renal and related cancers
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Sexuality, Behavior, and Technology
- Genital Health and Disease
- Sarcoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Glutathione Transferases and Polymorphisms
- Radiomics and Machine Learning in Medical Imaging
- Ovarian function and disorders
- Testicular diseases and treatments
Peking University
2022-2025
Crown College
2025
Peking University Cancer Hospital
2022-2025
Jinan University
2025
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2025
Anhui Medical University
2015-2024
First Affiliated Hospital of Anhui Medical University
2015-2024
Wuhan University of Science and Technology
2022-2024
Second Affiliated Hospital of Nanjing Medical University
2024
Union Hospital
2023
We studied the prevalence of prostatitis-like symptoms and identified their associated risk factors in a population based Chinese sample.A volunteer group 15,000 eligible men residing Beijing, Anhui, Xi'an, Guangzhou Gansu cities or provinces were invited randomly to take part survey complete questionnaire that elicited information regarding sociodemographics, Eysenck personality questionnaire, current stress health ratings, lifestyle, medical history, expressed prostatic secretion...
The heterogeneity of the immune microenvironment leads to different responses in checkpoint blockade therapy. We aimed propose a robust molecular classification system investigate relevance subtype and prognosis prostate cancer patients, as well therapeutic response A total 1,557 patients were enrolled, including 69 real‐world samples from our institute (titled AHMU‐PC cohort). non‐negative matrix factorization algorithm was employed virtually microdissect patients. enrichment characterized...
Immunotherapy is a potential way to save the lives of patients with bladder cancer, but it only benefits approximately 20% them. A total 4,028 cancer were collected for this study. Unsupervised non-negative matrix factorization and nearest template prediction algorithms employed classification. We identified immune non-immune classes from The Cancer Genome Atlas Bladder Urothelial Carcinoma (TCGA-BLCA) training cohort. 150 most differentially expressed genes between these two extracted,...
Abstract Clear cell renal carcinoma (ccRCC) is a heterogeneous tumor with different genetic and molecular alterations. Schemes for ccRCC classification system based on multiomics are urgent, to promote further biological insights. Two hundred fifty‐five patients paired data of clinical information, transcriptome expression profiles, copy number alterations, DNA methylation, somatic mutations were collected identification. Bioinformatic analyses performed our team's recently developed R...
ABSTRACT: This study was performed to evaluate the prevalence of erectile dysfunction (ED) and explore its correlation chronic prostatitis in China. A cross-sectional investigation from a large cohort Chinese men used this survey. questionnaire consisting general information regarding socio-demographics, disease history, sexual function, National Institutes Health–Chronic Prostatitis Symptom Index, International Index Erectile Function–5 (IIEF-5) administered 15 000 aged 60. The ED...
Clear cell renal carcinoma (ccRCC) has a high metastatic rate, and its incidence mortality are still rising. The aim of this study was to identify the key tumor-infiltrating immune cells (TIICs) affecting distant metastasis prognosis patients with ccRCC construct relevant prognostic panel predict immunotherapy response. Based on bulk RNA sequencing data, resting mast (RMCs) were screened verified using CIBERSORT algorithm, survival analysis, expression analysis. Distant metastasis-associated...
Cancer is a crucial public health problem and one of the leading causes death worldwide. Previous studies have suggested that GPX3 may be involved in cancer metastasis chemotherapy resistance. However, how affects patients' outcomes underlying mechanism remains unclear.Sequencing data clinical from TCGA, GTEx, HPA, CPTAC were used to explore relationship between expression features. Immunoinfiltration scores assess tumor immune microenvironment. Functional enrichment analysis was predict...
Abstract Prostate cancer (PCa), a severe health burden for males, accounts the second frequent and fifth tumor specific death around world. Several studies on tumor‐infiltrating immune cells (TIICs) have shown inconsistent controversial results to PCa. We downloaded gene expression matrix clinical information from TCGA, CIBERSORT was used identify proportion of TIICs. Wilcoxon's Sign Rank Test evaluated different levels in PCa normal tissues. Kaplan‐Meier curves were evaluate associations...
Penile cancer (PeCa) is a relatively rare tumor entity but possesses higher morbidity and mortality rates especially in developing countries. To date, the concrete pathogenic signaling pathways core machineries involved tumorigenesis progression of PeCa remain to be elucidated. Several studies suggested miRNAs, which modulate gene expression at posttranscriptional level, were frequently mis-regulated aberrantly expressed human cancers. However, miRNA profile has not been reported before. In...
Abstract Introduction In 2014, new evidence-based definitions of lifelong premature ejaculation (LPE) and acquired (APE) were proposed by the International Society for Sexual Medicine. Based on PE definitions, prevalence factors associated with LPE APE have not been investigated in China. Aim To evaluate men complaint Methods From December 2011 to 2015, a cross-sectional field survey was conducted five cities Anhui province Questionnaire data 3,579 collected our database. The questionnaire...
The purpose of this study is to investigate the effects adult male circumcision on premature ejaculation (PE). Therefore, between December 2009 and March 2014, a total 575 circumcised men 623 uncircumcised (control group) were evaluated. Detailed evaluations (including control groups) PE conducted before at 3-, 6-, 9-, 12-month follow-up visits after circumcision. Self-estimated intravaginal ejaculatory latency time (IELT), Patient-Reported Outcome measures, 5-item version International...
Clear cell renal carcinoma (ccRCC) is a common malignancy with high distant metastasis rate. Long non-coding RNAs (LncRNAs) are reported to be upregulated or downregulated in multiple cancers and play crucial role the of tumors prognosis. Therefore, purpose our study construct prognostic signature for ccRCC based on metastasis-related lncRNAs explore involved potential competitive endogenous RNA (ceRNA) network. The differentially expressed genes (DEGs) screened from database cancer genome...
Nitryl chloride (ClNO2) is a key precursor of chlorine radicals, influencing atmospheric oxidation and secondary pollutants formation. Few studies have examined the ClNO2 chemistry from perspective planetary boundary layer. Here, we conducted vertically resolved investigation at six heights (ranging 5 to 335 m) on 356 m tower in Pearl River Delta, China, during winter 2021. Nocturnal notably lower surface than upper layers, with nocturnal median concentration 220 (51 parts per trillion by...
ABSTRACT Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death in China. The rapid progress systemic therapies has led to approval many therapeutic methods that have quickly changed clinical guidelines and practices. Because high heterogeneity HCC, there are still some gaps between real‐world practice. present study surveyed experts China investigate current treatment concepts practice regarding HCC. Methods A questionnaire survey on HCC was...
Abstract Introduction: Tumor organoids replicate cancer lesions and capture tumor heterogeneity in vitro, are invaluable for drug development. Combining Patient-Derived Xenograft (PDX) models with corresponding Organoid (PDXO) offers a comprehensive approach, enabling high-throughput, scalable vitro data collection providing insights into behavior responses vivo. HER2 amplification is frequent cancers like breast gastric cancer, HER2-targeted ADCs have shown exceptional efficacy. To support...
Abstract Introduction: Antibody-drug conjugates (ADCs) represent a breakthrough therapeutic class that provides tumor-targeted cytotoxicity while stimulating immune responses, offering promising potential when combined with immunotherapies and particularly PD-1 inhibitors. Traditional xenograft tumor models developed in immunodeficient mice are employed to evaluate ADCs' anti-tumor efficacy. However, these lack competent systems human antigen expression normal tissues, limiting their...
<title>Abstract</title> Objectives Schizophrenia is a severe mental disorder imposing substantial burden worldwide. Understanding its impacts and trends in Asia crucial for devising effective intervention. This study quantified the prevalence, incidence, years lived with disability (YLDs) rates of schizophrenia across Asian regions, examine their trends, explore relationship between socio-demographic index (SDI) YLDs rates. Methods Data from Global Burden Disease (GBD) (1990–2021) were...
The aim of this study is to assess the status treatment chronic prostatitis (CP) in Chinese men.A population-based cross-sectional survey was performed, which 15 000 men aged between and 60 years were randomly selected receive a questionnaire designed National Institutes Health Chronic Prostatitis Symptoms Index (NIH-CPSI) status, therapeutic efficacy 28 other items.A total 12 743 (84.95%) completed questionnaire, whom 1 071 (8.4%) identified as having prostatitis-like symptoms 517 (4.5%)...