A5100400880- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Plant Molecular Biology Research
- Fungal Infections and Studies
- Chromosomal and Genetic Variations
- Plant Pathogens and Fungal Diseases
- Influenza Virus Research Studies
- Genomics and Chromatin Dynamics
- Plant Disease Resistance and Genetics
- Genetic diversity and population structure
- Genomic variations and chromosomal abnormalities
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA modifications and cancer
- Forensic and Genetic Research
- Genetic and phenotypic traits in livestock
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Epigenetics and DNA Methylation
- Plant-Microbe Interactions and Immunity
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
Fujian University of Traditional Chinese Medicine
2024-2025
Huizhou University
2020-2025
First Affiliated Hospital of Xiamen University
2025
Jinhua Central Hospital
2025
Zhejiang University
2025
Hunan Agricultural University
2013-2025
Harvard University
2020-2025
Harbin Veterinary Research Institute
2023-2025
Northwest A&F University
2025
Beijing University of Chinese Medicine
2024
Abstract Summary: A tool to predict the effect that newly discovered genomic variants have on known transcripts is indispensible in prioritizing and categorizing such variants. In Ensembl, a web-based (the SNP Effect Predictor) API interface can now functionally annotate all Ensembl Genomes supported species. Availability: The Predictor be accessed via website at http://www.ensembl.org/. (http://www.ensembl.org/info/docs/api/api_installation.html for installation instructions) open source...
Genomes from around the globe Genomic sequencing of diverse human populations to understand overall genetic diversity has lagged behind in-depth examination specific populations. To add our understanding diversity, Bergström et al. generated whole-genome sequences surveying individuals in Human Genome Diversity Project, which is a panel global that been instrumental history The authors' study adds data about African, Oceanian, and Amerindian indicates tends result differences at...
Genomes in the mist The mountain gorilla is an iconic species that at high risk of extinction. Xue et al. have sequenced 13 gorillas from two different populations to probe their genetic diversity. genomes show large tracts homozygosity and loss highly deleterious variants, indicating population bottlenecks inbreeding. This diversity appears started over 20,000 years ago may been caused by changes climate human-associated effects. Science , this issue p. 242
Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing varieties (i.e. grubii neoformans, respectively). Here, we sequenced the genome performed an RNA-Seq-based analysis of C. var. transcriptome structure. We determined chromosomal locations, analyzed sequence/structural features centromeres, identified origins replication. The was annotated based on automated manual curation. More...
Identifying Important Identifiers Each of us has millions sequence variations in our genomes. Signatures purifying or negative selection should help identify which those is functionally important. Khurana et al. ( 1235587 ) used polymorphisms from 1092 humans across 14 populations to patterns selection, especially noncoding regulatory regions. Noncoding regions under very strong included binding sites some chromatin and general transcription factors (TFs) core motifs important TF families....
Ensembl(http://www.ensembl.org)integrates genomic information for a comprehensive set of chordate genomes with particular focus on resources human, mouse, rat, zebrafish and other high-value sequenced genomes.We provide complete gene annotations all supported species in addition to specific that target genome variation, function evolution.Ensembl data is accessible variety formats including via our browser, API BioMart.This year marks the tenth anniversary Ensembl time project has grown...
We have assessed the numbers of potentially deleterious variants in genomes apparently healthy humans by using (1) low-coverage whole-genome sequence data from 179 individuals 1000 Genomes Pilot Project and (2) current predictions databases variants. Each individual carried 281–515 missense substitutions, 40–85 which were homozygous, predicted to be highly damaging. They also 40–110 classified Human Gene Mutation Database (HGMD) as disease-causing mutations (DMs), 3–24 homozygous state, many...
Kiwifruit (Actinidia chinensis) is one of the popular fruits world-wide, and its quality mainly determined by key metabolites (sugars, flavonoids, vitamins). Previous works on kiwifruit are mostly done via a single omics approach or involve only limited metabolites. Consequently, dynamic metabolomes during development ripening underlying regulatory mechanisms poorly understood. In this study, using high-resolution metabolomic transcriptomic analyses, we investigated metabolic landscapes at...
Stabilization of G-quadruplex structures in the promoter region certain oncogenes is an emerging field anticancer drug design. Human c-myc gene one these oncogenes, and G-quadruplexes have been proven to be transcriptional controller this gene. In present study, interaction quindoline derivatives with was investigated. The experimental results indicated that ability induce/stabilize c-myc, which lead down-regulation Hep G2 cell line. It found terminal amino groups their side chains would...
Abstract Background Rare coding variants constitute an important class of human genetic variation, but are underrepresented in current databases that based on small population samples. Recent studies show altering amino acid sequence and protein function enriched at low variant allele frequency, 2 to 5%, because insufficient sample size it is not clear if the same trend holds for rare below 1% frequency. Results The 1000 Genomes Exon Pilot Project has collected deep-coverage exon-capture...
Abstract Butterflies are exceptionally diverse but their potential as an experimental system has been limited by the difficulty of deciphering heterozygous genomes and a lack genetic manipulation technology. Here we use hybrid assembly approach to construct high-quality reference for Papilio xuthus (contig scaffold N50: 492 kb, 3.4 Mb) machaon 81 1.15 Mb), highly species that differ in host plant affiliations, adult larval colour patterns. Integrating comparative genomics analyses gene...
We have identified variants present in high-coverage complete sequences of 36 diverse human Y chromosomes from Africa, Europe, South Asia, East and the Americas, representing eight major haplogroups. After restricting our analysis to 8.97 Mb unique male-specific sequence, we 6662 high-confidence variants, including single-nucleotide polymorphisms (SNPs), multi-nucleotide (MNPs), indels. constructed phylogenetic trees using these or subsets them, recapitulated known structure tree. Assuming a...
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately 625,000 deaths per year from nervous system infections. Here, we leveraged a unique, genetically diverse population of C. sub-Saharan Africa, commonly isolated mopane trees, to determine how selective pressures in the environment coincidentally adapted for human virulence. Genome sequencing and phylogenetic analysis 387 isolates, representing global VNI African VNB lineages, highlighted deep, nonrecombining...
Abstract Background The maturing field of genomics is rapidly increasing the number sequenced genomes and producing more information from those previously sequenced. Much this additional variation data derived sampling multiple individuals a given species with goal discovering new variants characterising population frequencies that are already known. These have immense value for many studies, including designed to understand evolution connect genotype phenotype. Maximising utility requires...