A5100449298- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Cardiac Arrest and Resuscitation
- Pain Mechanisms and Treatments
- Urinary Bladder and Prostate Research
- Boron Compounds in Chemistry
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Neuroscience and Neuropharmacology Research
- Airway Management and Intubation Techniques
- Urinary Tract Infections Management
- Traditional Chinese Medicine Analysis
- Shoulder Injury and Treatment
- Ion Channels and Receptors
- Hemodynamic Monitoring and Therapy
- Cardiac Fibrosis and Remodeling
- Lung Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Spinal Fractures and Fixation Techniques
Second Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Xinjiang Medical University
2025
Fifth Affiliated Hospital of Xinjiang Medical University
2025
Nanjing Drum Tower Hospital
2025
Shanghai Children's Medical Center
2025
Shanghai Jiao Tong University
2025
Beijing Jishuitan Hospital
2020-2024
Peking University
2009-2024
Beijing Tongren Hospital
2013-2024
Heart failure is associated with a high rate of mortality and morbidity, ventricular remodeling invariably precedes heart failure. Ventricular fundamentally driven by mechanotransduction that regulated both the nervous system immune system. However, it remains unknown which key molecular factors govern neuro/immune/cardio axis underlies during remodeling. Here, we investigated whether mechanosensitive Piezo cation channel-mediated neurogenic inflammatory cascade remodeling-related...
Epidural anesthesia may attenuate the sympathetic hyperactivity and stress response from surgery. In this study, we compared response, hemodynamic variables, recovery profiles of patients undergoing total IV (TIVA) intraoperative dexmedetomidine with those receiving epidural TIVA.Ninety elective open gastrectomy under TIVA were recruited. The group (group D, n = 30) received 0.6 μg/kg before induction general anesthesia, followed by 0.4 μg/kg/h until peritoneal closure. control C,...
Alopecia areata (AA) is one of the most common autoimmune diseases and targets hair follicles, with high impact on quality life self-esteem patients due to loss. Clinical management outcomes are challenged by current limited immunosuppressive immunomodulating regimens. We have developed a Stem Cell Educator therapy in which patient's blood circulated through closed-loop system that separates mononuclear cells from whole blood, allows briefly interact adherent human cord blood-derived...
Liver disease is linked to series of extrahepatic multisystem manifestations. However, little known about the associations between liver and eye diseases, especially cataract, global leading cause blindness. We aimed investigate whether severe including non-alcoholic fatty (NAFLD), alcoholic (ALD), viral hepatitis, fibrosis cirrhosis, were associated with an increased risk cataract.
To explore the role of retinal and choroidal parameters obtained via optical coherence tomography (OCT) angiography (OCTA) in predicting thyroid-associated ophthalmopathy (TAO) activity, providing a scientific basis for improved clinical diagnosis treatment. This study included 90 active TAO patients (178 eyes), 69 inactive (138 66 healthy individuals (132 eyes). It compared magnetic resonance imaging structural differences, analyzed correlations between these parameters, developed...
Background Opioid receptors mediate cardiac ischemic preconditioning. Remifentanil is a new, potent ultra-short-acting phenylpiperidine opioid used in high doses for anesthesia. The authors hypothesize that pretreatment with this drug confers cardioprotection. Methods Male Sprague-Dawley rats were anesthetized and the chest was opened. All animals subjected to 30 min of occlusion left coronary artery 2 h reperfusion. Before 30-min occlusion, received either preconditioning by ischemia...
Background: Peripheral nerve block is a preferable method for elderly patients receiving hip arthroplasty. Sedation with dexmedetomidine may reduce postoperative delirium (POD). The aim of this study was to investigate whether intraoperative sedation dexmedetomidine, as supplementary peripheral total arthroplasty, can decrease the prevalence POD. Methods: A prospective, randomized controlled conducted 65 years age or older who underwent arthroplasty between June 2016 and 2017. were randomly...
Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain-associated is not yet described. This study investigates therapeutic potential single dose propofol (100 mg kg
Abstract Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 required for DNL. Mice lacking in liver exhibit hypolipidemia reduced levels of triglycerides, along with impaired hepatic lipogenesis. The expression genes involved glycolysis DNL, including two ChREBP isoforms, decreased livers knockout mice. binds enhances activity ChREBP-α promoter, suggesting...
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention, which has been discovered to reduce ischemia/reperfusion (I/R) injury in heart, kidney, brain and skeletal muscle experimentally. However, its potential protective mechanisms have not well elucidated. The aim of this study was investigate the effect RIPostC cerebral I/R explore new putative neuroprotection elicited by it. Focal ischemia induced transient middle artery occlusion (tMCAO) male CD1 mice....
The present study aimed to determine whether post-ischemic treatment with dexmedetomidine (DEX) protected the heart against acute myocardial ischemia/reperfusion (I/R)‑induced injury in rats. phosphatidylinositol‑3 kinase/protein kinase B(PI3K/Akt)‑dependent signaling pathway was also investigated. Male Sprague Dawley rats (n=64) were subjected ligation of left anterior descending artery (LAD), which produced ischemia for 25 min, followed by reperfusion. Following LAD ligation, treated DEX...
Abstract Alcoholic liver disease (ALD) is a chronic alcohol-induced disorder of the for which there are few effective therapies severe forms ALD and those who do not achieve alcohol abstinence. In this study, we used systematic drug-repositioning bioinformatics approach querying large compendium gene-expression profiles to identify candidate U.S. Food Drug Administration (FDA)–approved drugs treat ALD. One top compounds predicted be therapeutic by our was dimethyl fumarate (DMF), an nuclear...
BACKGROUND Dexmedetomidine is known to be a sedative. Recent studies suggest that administration of dexmedetomidine can prevent postoperative delirium (POD) which has been confirmed as common complication after major surgery. However, its effects in patients undergoing oesophagectomy are scarce. OBJECTIVE To investigate the efficacy and safety reducing POD elderly transthoracic with total intravenous anaesthesia (TIVA). DESIGN A randomised, double-blind, placebo-controlled trial. SETTING...
Remifentanil preconditioning (RPC) reduces the infarct size in anesthetized rat hearts, and this effect seems to be mediated by all three types of opioid receptors (ORs). Because there is evidence only kappa- delta- but not mu-ORs heart, authors investigated whether RPC confers cardioprotection via cardiac delta-OR as well extracardiac mu-OR agonist activity. The also involvement signaling mechanisms, namely protein kinase C mitochondrial adenosine triphosphate-sensitive potassium (KATP)...
Abstract A reaction cascade of aza‐Achmatowicz rearrangement followed by indole nucleophilic cyclization was developed to generate the common indole‐fused azabicyclo[3.3.1]nonane core macroline family alkaloids. The key success strategy relies on careful manipulation protecting groups and judicious selection chemoselective furan oxidation conditions. synthetic utility further demonstrated asymmetric total synthesis (−)‐alstofolinine A.
Cerebral ischemia reperfusion injury (IRI) induced by hemorrhagic shock and (HSR) is the main cause of death following trauma. Previous studies indicated neuroprotective effect sevoflurane postconditioning (SP) in cerebral IRI. However, mechanisms still remain elusive. IRI models with SP were established using HSR C57BL/6 mice (male, 3-month-old) vivo oxygen glucose deprivation reoxygenation (OGD/R) HT22 cells vitro. Postoperative cognition was evaluated Morris water maze, novel object...
Total laparoscopic hysterectomy (TLH) is a common surgical procedure that frequently associated with substantial postoperative pain. As part of multimodal analgesia, the erector spinae plane block (ESPB) and transmuscular quadratus lumborum (TQLB) have been demonstrated to be effective. This study aimed evaluate whether ESPB TQLB reduce pain opioid consumption after TLH. A total 90 female patients undergoing TLH were randomized receive either ESPB, TQLB, or no intervention before general...
Thyroidectomy is frequently associated with substantial postoperative pain. Esketamine, an N-methyl-d-aspartate receptor antagonist, has been demonstrated to be effective in multiple analgesia scenarios. We hypothesized that intraoperative administration of esketamine may reduce perioperative opioid consumption and pain patients undergoing thyroidectomy.Sixty thyroidectomy were randomly assigned two groups. Patients the group received a pre-incisional intravenous bolus (0.5 mg kg-1 )...
In Brief BACKGROUND: Small doses of intrathecal morphine provide cardioprotection similar to that conferred by IV morphine. However, the extent preconditioning (IT-MPC) relative resulting from ischemic (IPC) is unknown. Further, it uncertain whether IT-MPC mediated opioid receptor dependent pathways. this study, we compared with IPC and investigated role receptors in effect. METHODS: Eighty anesthetized, open-chest, male Sprague-Dawley rats were assigned 1 13 groups (n = 6–7) after...