A5075246876- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Attention Deficit Hyperactivity Disorder
- Pain Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Regulation of Appetite and Obesity
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Pharmacological Receptor Mechanisms and Effects
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Hormonal Regulation and Hypertension
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcoholism and Thiamine Deficiency
National Institute on Drug Abuse
2016-2025
National Institutes of Health
2016-2025
National Institute on Alcohol Abuse and Alcoholism
2016-2025
Office of the Director
2015-2024
Office of the Director
2023
Government of the United States of America
2023
Case Western Reserve University
2023
Scripps Research Institute
2010-2022
Versar (United States)
2022
Institute of Alcohol Studies
2020
Understanding the neurobiological mechanisms of addiction requires an integration basic neuroscience with social psychology, experimental and psychiatry. Addiction is presented as a cycle spiralling dysregulation brain reward systems that progressively increases, resulting in compulsive drug use loss control over drug-taking. Sensitization counteradaptation are hypothesized to contribute this hedonic homeostatic dysregulation, involved, such mesolimbic dopamine system, opioid peptidergic...
Differential access to cocaine self-administration produced two patterns of drug intake in rats. With 1 hour per session, remained low and stable. In contrast, with 6 hours access, gradually escalated over days. After escalation, consumption was characterized by an increased early loading upward shift the dose-response function, suggesting increase hedonic set point. month abstinence, escalation reinstated a higher level than before. These findings may provide animal model for studying...
Dopaminergic neurotransmission in the nucleus accumbens may be an important factor ethanol reinforcement and genetically determined preference. This hypothesis was tested by measuring dopamine (DA) release intracranial microdialysis during voluntary oral self-administration alcohol-preferring (P) heterogeneous Wistar rats. The animals were trained to respond for (10% w/v) or water a free-choice operant task. Extracellular DA levels subsequently monitored 30-min sessions 15-min "waiting...
Abstract Considerable evidence from preclinical and clinical investigations implicates disturbances of brain dopamine (DA) function in the pathophysiology several psychiatric neurologic disorders. We describe a neural model that may help organize theseindependent experimental observations. Cortical regions classically associated with limbic system interact infracortical structures, including nucleus accumbens, ventral pallidum, dorsomedial thalamus. In our model, overactivity forebrain DA...