A5100405272- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Neuroblastoma Research and Treatments
- Acute Kidney Injury Research
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
The University of Texas MD Anderson Cancer Center
2016-2025
Sichuan University
2021-2025
West China Second University Hospital of Sichuan University
2021-2025
Peking University Third Hospital
2020-2025
National Medical Products Administration
2023-2025
Sun Yat-sen University
2025
Shuozhou Central Hospital
2025
Guangzhou University of Chinese Medicine
2023-2025
Capital Medical University
2014-2025
Jiading District Central Hospital
2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme (ACE2) and causes disease 2019 (COVID-19). Here, through a genome-wide association study, we identify variant (rs190509934, minor allele frequency 0.2-2%) that downregulates ACE2 expression by 37% (P = 2.7 × 10-8) reduces the risk of SARS-CoV-2 infection 40% (odds ratio 0.60, P 4.5 10-13), providing genetic evidence levels influence COVID-19 risk. We also replicate...
Purpose: Primary urethral adenocarcinoma (PAC) is a rare malignancy associated with poor outcomes. There are 2 primary subtypes—clear cell (CCAC) and non–clear (nCCAC). In this study, we compare oncologic outcomes between CCAC vs nCCAC histological subtypes describe differences in treatment modalities. Materials Methods: We performed retrospective review of patients diagnosed PAC at our institution 1993 to 2024. Survival analysis was stratified by histologic subtype (CCAC nCCAC) modality....
Abstract Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors sensitivities frontline chemotherapy. We analyzed the mRNA expressions of signature genes in tumor samples from publicly available MD Anderson Cancer Center cohorts. developed a quantitative classifier transition (BLT) score which identified 80–94% sensitivity 83–93% specificity. In order facilitate subtyping...
Sarcomatoid urothelial bladder cancer (SARC) displays a high propensity for distant metastasis and is associated with short survival. We report comprehensive genomic analysis of 28 cases SARC 84 conventional carcinoma (UC), the TCGA cohort 408 muscle-invasive cancers serving as reference. SARCs show distinct mutational landscape, enrichment TP53, RB1, PIK3CA mutations. They are related to basal molecular subtype UCs could be divided into epithelial-basal more clinically aggressive...
BackgroundAbelmoschus manihot, a single medicament of traditional Chinese medicine, has been widely used to treat kidney disease. This is the first randomized controlled clinical trial assess its efficacy and safety in patients with primary glomerular disease.Study DesignProspective, open-label, multicenter, randomized, controlled, trial.Setting & ParticipantsFrom May 2010 October 2011, total 417 biopsy-proven disease from 26 hospitals participated study.InterventionsA manihot form huangkui...
Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAPdef) in tumors with 9p21 loss and hypothetically renders susceptible to synthetic lethality by antifolates targeting de novo purine synthesis. Here we report our single arm phase II trial (NCT02693717) that assesses pemetrexed MTAPdef urothelial carcinoma (UC) primary endpoint of overall response rate (ORR). Three 7 enrolled patients show (ORR 43%). Furthermore, a historic cohort...
Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI children, but causality needs to be further verified. An observational cohort study was conducted investigate association exposure risk of hospitalized The exposed group received while control did not. outcome accordance with Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Logistic...
Cardiovascular disease (CVD) represents a significant global health challenge, characterized by high incidence rates and substantial morbidity mortality. A newer index, the Cholesterol, High-Density Lipoprotein, Glucose (CHG) has been proposed as potential diagnostic tool for metabolic disorders but not investigated its ability to predict CVD risk. This study aims evaluate predictive efficacy of CHG index in comparison well-established Triglyceride–Glucose (TyG) index. In this cohort study,...
To investigate the perspectives and expectations of faculty radiologists, residents, medical students regarding integration artificial intelligence (AI) in radiology education, a survey was conducted to collect their opinions attitudes on implementing AI education. An online questionnaire used for this survey, participant anonymity ensured. In total, 41 38 120 from authors' institution completed questionnaire. Most residents experience different levels psychological stress during initial...
To describe the presentation, treatment and outcomes of patients with metastatic tumours to kidney treated at a tertiary referral centre.We retrospectively identified 151 diagnosed primary non-renal malignancy renal metastasis. Clinical, radiographic pathological characteristics were assessed. Overall survival (OS) was calculated using Kaplan-Meier methods.The median patient age 56.7 years. The most common presenting symptoms flank pain (30%), haematuria (16%) weight loss (12%). Most cancers...
In electron and proton radiotherapy, applications of patient‐specific bolus or compensators during radiation treatments are often necessary to accommodate patient body surface irregularities, tissue inhomogeneity, variations in PTV depths achieve desired dose distributions. Emerging 3D printing technologies provide alternative fabrication methods for these compensators. This study investigated the potential utilizing Two technologies, fused deposition modeling (FDM) selective laser sintering...
We examined the incidence, characteristics and treatment of patients with tumor bed recurrence after partial nephrectomy.We retrospectively reviewed charts 2,256 sporadic small renal masses treated nephrectomy between 2000 2014. Local was strictly defined as detection a new enhancing lesion 1) specifically in surgical defect or 2) same region (eg lower pole) site. To determine differences multiple 44 (1.9%) local were compared to 163 randomly selected who underwent no recurrence.Patients...
Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and internalization. While both are required for normal humoral immune responses, relationship between these processes is unknown. Herein, we demonstrate that following ligation, a small subpopulation receptors inductively phosphorylated selectively retained at surface where they can serve as scaffolds assembly molecules. In contrast, larger population non-phosphorylated rapidly endocytosed. Each undergo...
Thromboxane A 2 receptor (TPr) stimulation induces cellular hypertrophy in vascular smooth muscle cells (VSMCs); however, regulation of VSMC remains poorly understood. Here we show that TPr activates AMP-activated kinase (AMPK), which turn limits TPr-induced protein synthesis VSMCs. Exposure cultured VSMCs to either agonists, IBOP and U46619, or exogenous hydrogen peroxide (H O ) caused time- dose-dependent AMPK activation, as evidenced by increased phosphorylation both AMPK-Thr172...
When certain memory becomes obsolete, effective suppression of the previously established is essential for animals to adapt changing environment. At cellular level, reversal synaptic potentiation may be important neurons acquire new information and prevent saturation. Here, we investigated function Ca<sup>2+</sup>-stimulated cAMP signaling in regulation bidirectional plasticity spatial formation double knock-out mice (DKO) lacking both type 1 8 adenylyl cyclases (ACs). In anesthetized...