A5085657697- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Galectins and Cancer Biology
- Environmental Justice and Health Disparities
- Renal and related cancers
- Underground infrastructure and sustainability
- Central Venous Catheters and Hemodialysis
- Sustainable Building Design and Assessment
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Pediatric Urology and Nephrology Studies
- Acute Kidney Injury Research
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Biomarkers in Disease Mechanisms
- Iron Metabolism and Disorders
- Potassium and Related Disorders
- Microfluidic and Bio-sensing Technologies
- Parathyroid Disorders and Treatments
- Urban Green Space and Health
- Urban Planning and Valuation
National Taiwan University
2025
First Affiliated Hospital of Dalian Medical University
2015-2024
Northwestern Polytechnical University
2017-2024
Dalian Medical University
2015-2024
Xiamen University
2024
University of Hong Kong
2023-2024
Zhengzhou University of Aeronautics
2024
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
George Institute for Global Health
2017
Roxadustat (FG-4592) is an oral inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase that stimulates erythropoiesis and regulates iron metabolism. In phase 2 studies involving patients with chronic kidney disease, roxadustat increased levels endogenous erythropoietin to within or near the physiologic range, along increasing hemoglobin improving homeostasis. Additional data are needed regarding efficacy safety for treatment anemia in disease who not undergoing dialysis.
Treatment of lupus nephritis (LN) remains challenging.To assess the efficacy and safety a multitarget therapy consisting tacrolimus, mycophenolate mofetil, steroid compared with intravenous cyclophosphamide as induction for LN.24-week randomized, open-label, multicenter study. (ClinicalTrials.gov: NCT00876616).26 renal centers in China.Adults (aged 18 to 65 years) biopsy-proven LN.Tacrolimus, 4 mg/d, 1.0 g/d, versus starting dose 0.75 (adjusted 0.5 1.0) g/m2 body surface area every weeks 6...
FG-4592 (roxadustat) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (HIF-PHI) promoting coordinated erythropoiesis through the transcription HIF. Two Phase 2 studies were conducted in China to explore safety and efficacy of (USAN name: roxadustat, CDAN ), a HIF-PHI, patients with anemia chronic kidney disease (CKD), both who dialysis-dependent (DD) not (NDD). In NDD study, 91 participants randomized low (1.1–1.75 mg/kg) or high (1.50–2.25 starting doses placebo. DD 87...
Abstract Glomerular hypertension is an important factor exacerbating glomerular diseases to end-stage renal because, ultimately, it results in sclerosis (especially hypertensive and diabetic nephropathy). The precise mechanism of caused by unclear, due partly the absence suitable vitro or vivo models capable mimicking regulating complex mechanical forces and/or organ-level disease processes. We developed a “glomerulus-on-a-chip” (GC) microfluidic device. This device reconstitutes glomerulus...
BackgroundAbelmoschus manihot, a single medicament of traditional Chinese medicine, has been widely used to treat kidney disease. This is the first randomized controlled clinical trial assess its efficacy and safety in patients with primary glomerular disease.Study DesignProspective, open-label, multicenter, randomized, controlled, trial.Setting & ParticipantsFrom May 2010 October 2011, total 417 biopsy-proven disease from 26 hospitals participated study.InterventionsA manihot form huangkui...
Pulmonary fibrosis (PF) can severely disrupt lung function, leading to fatal consequences. Salidroside is a principal active ingredient of Rhodiola rosea and has recently been reported protect against injures. The present study was aimed at exploring its therapeutic effects on PF. Lung fibrotic injuries were induced in SD rats by single intratracheal instillation 5 mg/kg bleomycin (BLM). Then, these administrated with 50, 100, or 200 salidroside for 28 days. BLM-triggered structure...
The differentiation of fibroblasts, which are promoted by transforming growth factor-β (TGF-β)/Smad, is involved in the process pulmonary fibrosis. Rho/Rho-associated coiled-coil-forming protein kinase (Rock) pathway may regulate fibroblast and myofibroblast expression α-smooth muscle actin (α-SMA), however, mechanism not clear. aim present study was to evaluate role Rho/Rock TGF-β/Smad TGF-β1-induced lung fibroblasts differentiation. Human embryonic were stimulated TGF-β1, Y-27632...
The relationship between increased hemodialysis hours and patient outcomes remains unclear. We randomized (1:1) 200 adult recipients of standard maintenance from in-center home-based programs to extended weekly (≥24 hours) or (target 12–15 hours, maximum 18 for 12 months. primary outcome was change in quality life baseline assessed by the EuroQol 5 dimension instrument (3 level) (EQ-5D). Secondary included medication usage, clinical laboratory values, vascular access events, left ventricular...
Posttranslational modification of proteins could regulate their multiple biological functions. Transforming growth factor-β receptor I and II (ALK5 TGF-βRII), which are glycoproteins, play important roles in the renal tubular epithelial-mesenchymal transition (EMT). In present study, we examined role core fucosylation TGF-βRII ALK5, is regulated by α-1,6 fucosyltransferase (Fut8), process EMT cultured human proximal epithelial (HK-2) cells. The typical cell model induced TGF-β1 was...
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disorder with unknown etiology high mortality rate. Tanshinone ⅡA (Tan ⅡA) lipophilic diterpene extracted from the Chinese herb Salvia miltiorrhiza Bunge diverse biological functions. The present study was conducted to evaluate effects of Tan on bleomycin (BLM)‑induced in rats. Rats received an intraperitoneal injection normal rats were used as controls. Severe edema, inflammation observed BLM‑treated counts total...
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA), natural compound extracted from traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit injury liver in animal models, yet whether GA has therapeutic effect on unknown. In this study, we investigated the potential rat model with bleomycin (BLM)-induced fibrosis. The results indicated treatment...
Renal interstitial fibrosis (RIF) is an incurable pathological lesion in chronic kidney diseases. Pericyte activation the major characteristic of RIF. Fibroblast and macrophage are also involved Studies have revealed that core fucosylation (CF), important post-translational modification proteins, plays a key role pericyte RIF by regulating multiple profibrotic signaling pathways as hub-like target. Here, we reveal mesenchymal stem cell (MSC)-derived exosomes reside specifically injured...
Abstract Background Cognitive impairment is widely prevalent in maintenance hemodialysis (MHD) patients, and seriously affects their quality of life. The intestinal flora likely regulates cognitive function, but studies on MHD patients are lacking. Methods (36) healthy volunteers (18) were evaluated using the Montreal Function Scale, basic clinical data, 16S ribosome DNA (rDNA) sequencing. Twenty ten randomly selected for shotgun metagenomic analysis to explore potential metabolic pathways...
Abstract Introduction We previously found that mesenchymal stem cells (MSCs) injected intravenously could attenuate peritoneal adhesion by secreting tumor necrosis alpha-stimulating gene (TSG)-6, while MSCs intraperitoneally not. However, the underlying mechanism remains unclear. This study was designed to investigate means which exert their effects. Methods Rat bone marrow-derived MSCs/red fluorescent protein (RFP) were either or into Sprague-Dawley (SD) rats at different time points after...