A5100332778- Microbial Natural Products and Biosynthesis
- Connexins and lens biology
- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Retinoids in leukemia and cellular processes
- Trace Elements in Health
- Cancer therapeutics and mechanisms
- Microbial Metabolism and Applications
- Phytochemistry and Biological Activities
- Synthesis and Biological Activity
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Genomics, phytochemicals, and oxidative stress
- Food composition and properties
- Computational Drug Discovery Methods
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
Harbin Medical University
2023-2025
Jilin University
2025
China Pharmaceutical University
2023-2025
First Affiliated Hospital of Dalian Medical University
2024-2025
Dalian Medical University
2024-2025
Air Force General Hospital PLA
2025
China Geological Survey
2024-2025
Jilin Agricultural University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2010-2024
Many agricultural species and their pathogens have sequenced genomes more are in progress. Agricultural provide food, fiber, xenotransplant tissues, biopharmaceuticals biomedical models. Moreover, many microorganisms human zoonoses. However, systems biology from functional genomics data is hindered because genome sequences relatively poor structural annotation research communities smaller with limited funding compared to model organism communities.To facilitate these traditionally we...
BackgroundDrug delivery and penetration into neoplastic cells distant from tumor vessels is critical for the effectiveness of solid chemotherapy. We hypothesized that 10- to 20-nm nanoassemblies phospholipids containing doxorubicin would improve drug's penetration, accumulation, antitumor activity.
Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, molecular determinants controlling connexin-hemichannel activity are unresolved. Here we investigated Cx43-hemichannel by actomyosin contractility intracellular [Ca2+] ([Ca2+]i) using plasma membrane-permeable TAT peptides (100 µM) designed to interfere with interactions between cytoplasmic loop (CL) carboxy-terminal...
Abstract Simultaneous photothermal therapy (PTT) and photodynamic (PDT) is beneficial for enhanced cancer due to the synergistic effect. Conventional materials developed PTT/PDT are generally multicomponent agents that need complicated preparation procedures be activated by multiple laser sources. The emerging monocomponent diketopyrrolopyrrole (DPP)-based conjugated small molecular enable dual under a single irradiation, but suffer from low singlet oxygen quantum yield, which severely...
Significance In cereal crops, the number of florets in a spikelet is an important factor affecting grain per panicle and then yield. wild-type rice, one produces fertile floret. This study characterized gain-of-function mutant lateral 1 ( lf1 ) rice. , developed with proper floral organ identities axil sterile lemma, showing that rice has potential to restore “three-florets spikelet” which may have existed ancestors. Therefore, it provides strong evidence supporting three-florets hypothesis...
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While junctions are crucial for electrical conduction in heart, little is known about potential roles of hemichannels. Recent evidence suggests inhibiting Cx43 hemichannel opening with Gap19 has antiarrhythmic effects. Here, we used multiple electrophysiology, imaging, and super-resolution techniques understand define conditions underlying activation ventricular...
The gastrointestinal tract is a key source of superoxide so as to be one the most vulnerable oxidative stress damage. Ellagic acid (EA), polyphenol displays widely biological activities owing its strong antioxidant properties. Here, we investigated protective benefits EA on and intestinal barrier injury in paraquet (PQ)-challenged piglets. A total 40 weaned piglets were randomly divided into five groups: Control, PQ, 0.005% EA-PQ, 0.01% 0.02% EA-PQ. Piglets intraperitoneally injected with 4...
Imidacloprid (IMI) is among the common neonicotinoid insecticides used in agriculture worldwide, posing a potential toxic threat to non-target animals and humans. Numerous studies have shown that ferroptosis involved pathophysiological progression of renal diseases. However, it remains unclear whether IMI-induced nephrotoxicity. In present study, we investigated pathogenic role kidney damage vivo. Transmission electron microscopy (TEM) showed mitochondrial crest cells significantly decreased...
Accurate knowledge of the intracellular location proteins is important for numerous areas biomedical research including assessing fidelity putative protein-protein interactions, modeling cellular processes at a system-wide level and investigating metabolic disease pathways. Many have not been localized, or incompletely partly because most studies do account entire subcellular distribution. Thus, are frequently assigned to one organelle whereas significant fraction may reside elsewhere. As...
This study aimed to investigate the amendatory effects of Fu brick tea aqueous extract (FTE) on constipation and its underlying molecular mechanism. The administration FTE by oral gavage (100 400 mg/kg·bw) for 5 weeks significantly increased fecal water content, improved difficult defecation, enhanced intestinal propulsion in loperamide (LOP)-induced constipated mice. also reduced colonic inflammatory factors, maintained tight junction structure, inhibited Aquaporins (AQPs) expression, thus...
Necroptosis has emerged as a novel molecular pathway that can be targeted by chemotherapy agents in the treatment of cancer. OSW-1, which is derived from bulbs
purpose. Elevated intraocular pressure (IOP), the major causal risk factor for glaucoma, often decreases after cataract removal by phacoemulsification ultrasound. In this study, hypothesis that ultrasound energy propagated through a fluid medium induces stress response with potential to lower IOP was investigated. methods. Normal and glaucomatous trabecular meshwork (TM) cell culture lines were initiated from tissue isolated human cadaveric eyes or trabeculectomy specimens. Cultured cells...