A5100652666- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Connexins and lens biology
- Ocular Infections and Treatments
- Retinal Imaging and Analysis
- Cancer-related gene regulation
- Pesticide Residue Analysis and Safety
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Tea Polyphenols and Effects
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Dermatologic Treatments and Research
- Animal Nutrition and Physiology
- Hemophilia Treatment and Research
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- Coccidia and coccidiosis research
- Retinal Development and Disorders
- Ginseng Biological Effects and Applications
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Qingdao Agricultural University
2021-2025
Beijing Water Science and Technology Institute
2022-2025
Guizhou University
2025
Jiangsu Provincial Center for Disease Control and Prevention
2024
Beijing Anding Hospital
2024
Taiyuan Central Hospital
2024
Sichuan Agricultural University
2022-2024
Tianjin Medical University
2023-2024
To study dry eye and analyze pathogenic factors in patients after cataract surgery.A total of 37 (50 eyes) were studied by using a 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ25) Ocular Surface Disease Index (OSDI) 3 days before 1 week, month, months surgery. Slit-lamp microscope examination, cornea conjunctiva fluorescein staining, tear breakup time (BUT), Schirmer test I (STI), impression cytology (IC) carried out at the same time. Cytologic specimens for IC...
Objective To explore the risk factors of diabetic retinopathy (DR) and sight-threatening (STDR) among Chinese patients with diabetes. Design, setting participants A cross-sectional investigation was performed in eight screening clinics six provinces across mainland China. Information about recorded clinics. Some (sex, age, diagnosis diabetes duration, systolic blood pressure (SBP), diastolic pressure, fasting glucose (FBG) glycosylated haemoglobin (HbA1c)) were all clinics, while others...
Purpose. This study aims to explore the safety and efficacy of a novel treatment-intense pulsed light (IPL) in MGD eyes. Methods. is prospective open label study. Forty eyes 40 patients were recruited received 4 consecutive IPL treatments on day 1, 15, 45, 75. Ten ocular surface symptoms evaluated with subjective face score at every visit. Best spectacle corrected visual acuity, intraocular pressure (IOP), conjunctival injection, upper lower tear meniscus height (TMH), break-up time (TBUT),...
Abstract Background Alzheimer’s disease (AD) is a degenerative neurological disorder. Recent studies have indicated that histone deacetylases (HDACs) are among the most prominent epigenetic therapy targets and HDAC inhibitors therapeutic effects on AD. Here, we identified sodium valproate (VPA), pan-HDAC inhibitor, WT161, novel HDAC6 selective as potential agents for Underlying molecular mechanisms were investigated. Methods A cellular model, N2a-APPswe, was established via lentiviral...
Evapotranspiration (ET) plays a crucial role in the surface water cycle and energy balance, accurate ET estimation is essential for study various domains, including agricultural irrigation, drought monitoring, resource management. Remote sensing (RS) technology presents an efficient approach estimating at regional scales; however, existing RS retrieval algorithms are intricate necessitate multitude of parameters. The land temperature–vegetation index (LST-VI) space method statistical...
Mucositis is a common problem that results from cancer chemotherapy and cause of significant morbidity occasional mortality. Its prevention successful treatment can significantly enhance the quality life patients improve their survival. Sea cucumber traditional aquatic food has both nutritional medicinal value. The polysaccharide fucoidan sea (SC-FUC) various bioactivities. We examined protective effect different molecular weights (MWs 50 kDa-500 kDa) cucumber, Acaudina molpadioides, in...
To explore the composition of ocular microbiome in normal subjects and patients with Meibomian gland dysfunction (MGD).Seventy (140 eyes) were enrolled our study. Signs dry eye evaluated bacterial species conjunctival sac (CS) (MG) secretions then identified by 16S rRNA gene sequencing. Additionally, 17 (34 further to determine differences microbiomes surface deep layers MG using a segmental secretion analysis.The positive isolation rate was markedly higher than CS. The control mild group...
The effects of chlorogenic acid (CGA) on growth performance, anticoccidial indicators (oocysts per gram excreta, cecal lesion score, and bloody diarrhea score), immunity, antioxidant status, intestinal barrier function in coccidia-infected broilers were investigated. A total 240 one-day-old Arbor Acres randomly divided into four groups with six replicates ten each for 42 days. Four treatments included control diet (non-infected control, NC), +Eimeria infection (infected IC), +0.5 g/kg CGA +...
Intensive production can cause immunological stress in commercial broilers. Chlorogenic acid (CGA) regulates the intestinal microbiota, barrier function, and immune function chickens. As complex interrelations regulate dynamic interplay between gut host, diverse health outcomes, aim of this study was to elucidate immunoregulatory mechanisms CGA using multi-omics approaches. A total 240 one-day-old male broilers were assigned a 2 × factorial design with levels (0 or 500 mg/kg) either without...
Objective To describe the prevalence and severity of diabetic retinopathy (DR) sight-threatening DR (STDR) among Chinese adults with diabetes. Design, setting participants A cross-sectional epidemiological survey across Mainland China (N=13 473). Participants were diagnosed diabetes mellitus by physicians transferred to our screening clinics (1/3 from hospital patients, 1/3 city residents, other rural residents). 2 fundus photographs taken each eye a colourful, non-mydriatic non-stereoscopic...
Abstract Background Gap junction protein alpha 3 ( GJA3 ), an important pathogenic gene of congenital cataracts, encodes the transmembrane connexin46, which functions as intercellular channel for voltage and chemical gating by forming dodecamers. This study systematically collected nsSNP information from SNP databases literature screened nsSNPs with high risks pathogenicity. Results A total 379 were identified. 88 high-risk found, including 31 published associated cataracts 57 novel...
Purpose: The purpose of this study was to establish a deep learning model for automated sub-basal corneal nerve fiber (CNF) segmentation and evaluation with in vivo confocal microscopy (IVCM). Methods: A network (CNS-Net) established convolutional neural networks based on algorithm evaluation. CNS-Net trained 552 tested 139 labeled IVCM images as supervision information collected from July 2017 December 2018 Peking University Third Hospital. These were by three senior ophthalmologists ImageJ...
Coccidiosis is one of the major parasitic diseases in commercial broiler industry. Probiotics can protect poultry against Eimeria infection. However, mechanisms are not fully known. Therefore, Lactobacillus plantarum P8 (P8) was used to investigate its anti-coccidial property and mechanism. Five hundred broilers were allocated five treatments: control diet (NC), + infection (IC), containing 1 × 10 7 cfu/g (P8L), 8 (P8H), Diclazuril (DIC). At day 14, all treatments except NC inoculated with...
Oxidation is a major cause of meat quality deterioration during broiler production, which leads to undesirable color and impaired water holding capacity (WHC), thereby impacting consumer appeal satisfaction. Chlorogenic acid (CGA), natural phenolic acid, regarded as potential, safer healthier antioxidant improve quality. To investigate the protective effects CGA on oxidatively stressed broilers, 240 one-day-old male Cobb chickens were allocated four treatments: basal diet (control group), +...
We aimed to determine the current incidence rate and risk factors for surgical site infection (SSI) after abdominal surgery in China further demonstrate clinical features of patients with SSI.Contemporary epidemiology SSI remain poorly characterized.A prospective multicenter cohort study was conducted from March 2021 February 2022; included who underwent at 42 hospitals China. Multivariable logistic regression analysis performed identify SSI. Latent class (LCA) used explore population...
Two germline retrotransposition mutations of recent origin were observed in 727 independent (0.28%) the human factor IX gene (F9) patients with hemophilia B: 1) a 279 bp insertion exon H originating from an Alu family short interspersed elements not previously known to be active and, 2) 463 E LINE1 element maternal grandmother. If rates mutation F9 are typical genome, event is estimated occur somewhere genome about one every 17 children born. Analysis other estimates for frequency and...
The presence of homoeologous sequences and absence a reference genome sequence make discovery genotyping single nucleotide polymorphisms (SNPs) more challenging in polyploid crops.To address this challenge, we constructed reduced representation libraries (RRLs) for two Brassica napus inbred lines their 91 doubled haploid (DH) progenies using modified ddRADseq technique. A bioinformatics pipeline termed RFAPtools was developed to discover genotype SNPs presence/absence variations (PAVs)....