Haijun Yang

ORCID: 0000-0003-3273-3455
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About
Contact & Profiles
Research Areas
  • Plant and Fungal Species Descriptions
  • Plant and animal studies
  • Cancer-related gene regulation
  • Biological and pharmacological studies of plants
  • Plant Gene Expression Analysis
  • Plant Diversity and Evolution
  • Tea Polyphenols and Effects
  • Plant Reproductive Biology
  • Plant Parasitism and Resistance
  • Pancreatitis Pathology and Treatment
  • Catalytic Processes in Materials Science
  • Phytochemicals and Antioxidant Activities
  • Pancreatic and Hepatic Oncology Research
  • Plant Molecular Biology Research
  • RNA modifications and cancer
  • GABA and Rice Research
  • Prostate Cancer Treatment and Research
  • Cancer, Hypoxia, and Metabolism
  • Allelopathy and phytotoxic interactions
  • Esophageal and GI Pathology
  • Light effects on plants
  • Microbial Applications in Construction Materials
  • Aerosol Filtration and Electrostatic Precipitation
  • Diet and metabolism studies
  • Cancer-related molecular mechanisms research

Second People’s Hospital of Huai’an
2025

Xuzhou Medical College
2025

Anyang Tumor Hospital
2014-2024

Xiangya Hospital Central South University
2021-2024

Central South University
2021-2024

South China Agricultural University
2011-2023

National Clinical Research Center for Digestive Diseases
2021

Kunming Medical University
2019

Hallym University
2014

Satellite Application Center for Ecology and Environment
2010

A new species of Gastrodia (Orchidaceae: Epidendroideae, Gastrodieae), G. qingyunshanensis, is described and illustrated from Guangdong, China. It closely related to appendiculata C. S. Leou & N. J. Chung but can be distinguished by an urceolate (vs bell-like) dark brown pale greenish brown) perianth tube, the smaller petals (2.5 × 1.6 mm vs 4–5 5–6 mm), shape lip (oblong, 3×1.6mm ovate, 6–7×5mm), lack elevated calli at base petal having calli), appendage shorter than column equal...

10.11646/phytotaxa.483.2.10 article EN Phytotaxa 2021-02-10

A variant of tea tree (Camellia sinensis (L.)) with purple buds and leaves pink flowers can be used as a unique ornamental plant. However, the mechanism flower coloration remains unclear. To elucidate molecular coloration, well anthocyanin accumulation in white flowers, metabolite profiling transcriptome sequencing was analyzed various developmental stages. Results metabolomics analysis revealed that three specific substances could identified, i.e., cyanidin O-syringic acid, petunidin...

10.3390/molecules25010190 article EN cc-by Molecules 2020-01-02

Almost all flowers of the tea plant (Camellia sinensis) are white, which has caused few researchers to pay attention anthocyanin accumulation and color changing in flowers. A new purple-leaf cultivar, Baitang purple (BTP) was discovered Mountains Guangdong, whose naturally pink, can provide an opportunity understand metabolic networks flower development In present study, twelve components were identified pink flowers, namely cyanidin O-syringic acid, petunidin 3-O-glucoside, pelargonidin...

10.3390/molecules24061064 article EN cc-by Molecules 2019-03-18

The prognostic role of serum alkaline phosphatase (ALP) has been found in several kinds solid malignant tumor, but never extensively discussed pancreatic cancer, especially through the application dynamic survival model which incorporates varying nature ALP measurements.We conducted a retrospective study successfully collected 551 histopathologically confirmed ductal adenocarcinoma (PDAC) patients from cancer specialized hospital southwest China. association between variant measured during...

10.1186/s12885-019-6004-7 article EN cc-by BMC Cancer 2019-08-07

Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT pancreatic (PC) survival lacks adequate evaluation. In this study, we aimed to analyze association between measured at diagnosis overall (OS) patients with metastatic PC.We identified 320 histopathologically confirmed ductal adenocarcinoma (PDAC) diagnosed during 2015 2016 a specialized hospital southwestern China. Univariate...

10.1186/s12885-019-6250-8 article EN cc-by BMC Cancer 2019-10-29

Bone metastasis is a serious complication following radical prostatectomy in prostate cancer patients, significantly affecting their long-term survival. This study aims to develop clinical predictive model utilizing Magnetic Resonance Imaging (MRI) and advanced machine learning algorithms identify key factors that increase the risk of bone (BM). The analyzed cohort 1161 including 38 who developed metastasis. Preoperative T2-weighted images (T2WI) were obtained, tumor lesions manually...

10.3389/fonc.2025.1549851 article EN cc-by Frontiers in Oncology 2025-02-19

BACKGROUND Differential diagnosis among atypical hyperplasia (AH) (including reparative and intestinal metaplasia), low-grade dysplasia (LGD), high-grade (HGD), adenocarcinoma (AC) in gastric mucosal biopsies is challenging due to histomorphological overlaps, variability pathological consistency, limited reproducibility. AIM To evaluate the diagnostic utility of P53, Ki67, P504S, IMP3 cancer its precancerous lesions, focusing on their effectiveness distinguishing AH, LGD, HGD, AC. METHODS...

10.4251/wjgo.v17.i5.105604 article EN World Journal of Gastrointestinal Oncology 2025-05-15

Lenvatinib is the latest and promising agent that has demonstrated a significant improvement of progression-free survival in advanced hepatocellular carcinoma (HCC). However, resistance emerges soon after initial treatment, limiting clinical benefits lenvatinib. Therefore, understanding mechanism necessary for improving lenvatinib efficacy. YRDC promotes proliferation hepatocarcinoma cells via regulating activity RAS/RAF/MEK/ERK pathway, which was primary pathway anticancer effect The...

10.3389/fphar.2021.744578 article EN cc-by Frontiers in Pharmacology 2021-10-01

Leaf color is one of the key factors involved in determining processing suitability tea. It relates to differential accumulation flavor compounds due different metabolic mechanisms. In recent years, photosensitive etiolation or albefaction an interesting direction tea research field. However, molecular mechanism formation remains unclear since albino etiolated mutants have genetic backgrounds. this study, wide-target metabolomic and transcriptomic analyses were used reveal biological leaf...

10.3390/ijms232315044 article EN International Journal of Molecular Sciences 2022-11-30

Abstract β -Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, mechanisms by which Wnt/ -catenin signaling components regulate physiological events during brain remain undetermined. Inactivation glycogen synthase kinase (GSK)-3 leads to accumulation nucleus, where it couples with T-cell factor (TCF), an association that is disrupted ICAT (inhibitor T cell factor). In this study, we sought determine whether members microRNA-29...

10.1038/cddis.2014.439 article EN cc-by Cell Death and Disease 2014-10-16

Self-incompatibility (SI) is a type of reproductive barrier within plant species and one the mechanisms for formation maintenance high diversity adaptation angiosperm species. Approximately 40% flowering plants are SI species, while only 10% orchid self-incompatible. Intriguingly, as largest genera in Orchidaceae, 72% Dendrobium self-incompatible, accounting nearly half reported orchids, suggesting that contributes to However, few studies investigating have been published. This study aimed...

10.3390/ijms19092595 article EN International Journal of Molecular Sciences 2018-09-01

In controlled environment agriculture, optimization of lighting regimes, i.e. daily light integral (DLI, photosynthetic photon flux density (PPFD) x photoperiod duration), plays vital roles to maximize harvestable yield and reduce costs. Regulating PPFD or have been widely used for energy-efficient cultivation, while the mechanisms multiple DLI contributing photosynthesis capacity are poorly understood. Hence, treatment 16/8 h light/dark compared with 24 continuous (CL), at 200 300 μmol m−2...

10.1016/j.scienta.2023.112715 article EN cc-by-nc-nd Scientia Horticulturae 2023-12-08

Compound probiotics have been widely used and commonly co-administered with other drugs for treating various chronic illnesses, yet their effects on drug pharmacokinetics remain underexplored. This study elucidated the impact of VSL#3 metabolism probe cytochrome P450 enzymes (CYP450s), specifically omeprazole, tolbutamide, midazolam, metoprolol, phenacetin chlorzoxazone. Male Wistar rats were administered drinking water containing or not 14 days then intragastrically a CYP450s cocktail; was...

10.1124/dmd.124.001837 article EN Drug Metabolism and Disposition 2024-08-30

Two new species of Aristolochia (Aristolochiaceae), A. ledongensis Han Xu, Y. D. Li & H. J. Yang and jianfenglingensis Q. Chen, are described illustrated from Hainan Island, China. differs the similar championii Merr. Chun bambusifolia C. F. Liang ex Wen by having exterior calyx yellow (vs. yellowish green), a smaller basal portion tube (15–16 × 4.5–5 mm vs. 30–70 7–10 mm), narrower limb (0.5–0.7 cm 1.5–6 wide), shorter peduncle (0.7–1 1.8–5 cm). stems glabrous densely villous), light...

10.3417/2009116 article EN Novon A Journal for Botanical Nomenclature 2011-06-01

Litchi is one of the most important subtropical evergreen fruit trees in Southern Asia. floral buds are a mix axillary or apical panicle primordia, leaf and rudimentary leaves. Under usual winter early spring conditions, primordia prevail, leaves abscise when low temperatures reach certain threshold. The ultimately develop into pure panicles. Understanding regulatory mechanism senescence great importance for litchi flowering. In this study, potted at differentiation stage were treated with...

10.1007/s10535-016-0667-6 article EN Biologia Plantarum 2016-11-11

Purpose: The present study focused on exploring the associations of Porphyromonas gingivalis (P. gingivalis) infection and low Beclin1 expression with clinicopathological parameters survival esophageal squamous cell carcinoma (ESCC) patients, so as to illustrate its clinical significance prognostic value. Methods: Immunohistochemistry (IHC) was used detect P. status in 370 ESCC patients. chi-square test adopted relationship between categorical variables, Cohen's kappa coefficient for...

10.3389/pore.2021.1609976 article EN cc-by Pathology & Oncology Research 2021-12-08

Thismia jinzun, a new fully mycoheterotrophic species has been discovered from Hainan Province, China. jinzun is similar to T. javanica and tentaculata in overall appearance, but it obviously differs the latter two several characters. 10–12 mm long, gold-yellow tepal appendages (vs 20–30 orange-white javanica, ca. 17 orange-red tentaculata), floral tube pale orange or yellow white annulus bright tentaculata). According IUCN criteria, conservation status of classified as Critically Endangered (CR).

10.11646/phytotaxa.664.4.4 article EN Phytotaxa 2024-09-12

Background: This study aims to explore the role of RCAN1 in esophageal squamous cell carcinoma (ESCC) cells, determine mRNA level three isoforms ESCC tissue, and evaluate prognostic value isoforms. Methods: Colony-forming assay, Wound-healing assay Transwell were used effect on proliferation, migration invasion. The expression was detected paired tumor normal tissues from 100 patients by real-time PCR. Kaplan-Meier survival curves Cox proportional hazards model A nomogram predict probability...

10.7150/jca.84307 article EN cc-by-nc Journal of Cancer 2023-01-01

Dioscorea cirrhosa is a plant that used as dye well in medicine. Many metabolites with pharmacological activity exist the tubers of D. . However, little known about mechanism regulating biosynthesis these metabolites. In this study, transcriptome and metabolome profiling were performed four color tubers. A total 531 metabolites, including 62 flavonoids, identified. Epicatechin proanthocyanin B2 key exhibited high content levels These divided into nine classes distinct change patterns. 22,865...

10.7717/peerj.13659 article EN cc-by PeerJ 2022-07-04

Neolamarckia macrophylla (Rubiaceae) is a fast-growing tree with high economic value that endemic to Sulawesi and Moluccas, Indonesia. Here, we presented the complete chloroplast (cp) genome sequence of N. macrophylla. The 155,406 bp in size includes large single-copy region (86,013 bp), small (18,063 pair IR regions (25,665 each). A total 128 genes were predicted, including 8 rRNA, 36 tRNA, 84 protein-coding genes. Phylogenetic analysis based on 11 plant species genomes indicated genus was...

10.1080/23802359.2020.1745709 article EN cc-by Mitochondrial DNA Part B 2020-03-27

To obtain the appropriate mechanized cutting region for banana dehanding, methods of X-ray Computed Tomography (CT), Paraffin-embedded tissue section, and scanning electron microscopy (SEM) were adopted to observe morphological anatomical characteristics vascular bundles crown. The results indicated that crown can be divided into three regions, viz., central stalk–crown transition (CSCTR), expansion (CER), crown–finger (CFTR). According obtained characteristics, mechanical properties are...

10.3390/agronomy10081199 article EN cc-by Agronomy 2020-08-14
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