Objective To explore the risk factors of diabetic retinopathy (DR) and sight-threatening (STDR) among Chinese patients with diabetes. Design, setting participants A cross-sectional investigation was performed in eight screening clinics six provinces across mainland China. Information about recorded clinics. Some (sex, age, diagnosis diabetes duration, systolic blood pressure (SBP), diastolic pressure, fasting glucose (FBG) glycosylated haemoglobin (HbA1c)) were all clinics, while others...

Purpose. This study aims to explore the safety and efficacy of a novel treatment-intense pulsed light (IPL) in MGD eyes. Methods. is prospective open label study. Forty eyes 40 patients were recruited received 4 consecutive IPL treatments on day 1, 15, 45, 75. Ten ocular surface symptoms evaluated with subjective face score at every visit. Best spectacle corrected visual acuity, intraocular pressure (IOP), conjunctival injection, upper lower tear meniscus height (TMH), break-up time (TBUT),...

Objective To describe the prevalence and severity of diabetic retinopathy (DR) sight-threatening DR (STDR) among Chinese adults with diabetes. Design, setting participants A cross-sectional epidemiological survey across Mainland China (N=13 473). Participants were diagnosed diabetes mellitus by physicians transferred to our screening clinics (1/3 from hospital patients, 1/3 city residents, other rural residents). 2 fundus photographs taken each eye a colourful, non-mydriatic non-stereoscopic...

Abstract Background Gap junction protein alpha 3 ( GJA3 ), an important pathogenic gene of congenital cataracts, encodes the transmembrane connexin46, which functions as intercellular channel for voltage and chemical gating by forming dodecamers. This study systematically collected nsSNP information from SNP databases literature screened nsSNPs with high risks pathogenicity. Results A total 379 were identified. 88 high-risk found, including 31 published associated cataracts 57 novel...

To assess air pollution-induced changes on ocular surface and tear cytokine levels.As a prospective multicenter cohort study, 387 dry eye disease (DED) participants were recruited from five provinces in China underwent measurements of index (OSDI), Schirmer's I test (ST), meniscus height (TMH), film break-up time (TBUT), corneal fluorescein staining (CFS), meibomian gland (MG) function, cytokines. The associations between parameters exposure to particulate matter (PM), ozone (O3), nitrogen...

Abstract Purpose The present study aimed to investigate and compare the psychometric properties of National Eye Institute Visual Functioning Questionnaire‐25 (NEI VFQ‐25) Function Index‐14 (VF‐14) in a large sample patients with cataracts. Methods A total 1052 bilateral age‐related cataracts were recruited study. Patients other comorbidities that severely impacted vision excluded. Participants completed two questionnaires random order. Classical test theory Rasch analyses used assess...

Platinum-based chemotherapy is an important therapeutic approach for patients with advanced non-small cell lung cancer (NSCLC) without driver gene mutations. DNA damage and repair (DDR) can mitigate platinum-induced induce resistance to platinum agents. The status of DDR in wild-type NSCLC their role determining response prognosis platinum-based need be investigated. This study used next-generation sequencing (NGS) detect the mutation 47 genes seven signaling pathways investigate association...

In order to provide a cost-effective method narrow down the number of pathogenic Crystallin beta A4 (CRYBA4) non-synonymous single nucleotide polymorphisms (nsSNPs), we collected nsSNP information CRYBA4 gene from SNP databases and literature, predicting pathogenicity possible changes protein properties structures using multiple bioinformatics tools. The data were 4 published literature. According 12 criteria, six tools chosen predict pathogenicity. I-Mutant 2.0, Mupro INPS online used...

Abstract Conjunctivochalasis (CCh) disrupts tear flow and damages film stability. This study sought to evaluate the stability contrast sensitivity of patients with CCh on whom excision was performed. The included 39 eyes from patients; all had grade 2 or 3 CCh, underwent excision, were evaluated before three months after surgery. variables ocular surface disease index (OSDI), break-up time (TBUT), corneal fluorescein staining, irregularity, Schirmer’s I test, meniscus area (TMA),...

This study aimed to evaluate the efficacy and safety of a new-generation intense pulsed light (IPL) device in improving symptoms signs meibomian gland dysfunction (MGD)-related dry eye, compare it with traditional IPL device.This multicenter randomized controlled trial enrolled 132 patients MGD-related eye from two centers. Patients were randomly assigned into (Eyesis) group or (E-Eye) group, then blinded receive treatment on days 0 7. Ocular Surface Disease Index (OSDI), tear meniscus...

To investigate the changes of intraocular pressure (IOP) induced by 3-diopter (3 D) accommodation in progressing myopes, stable myopes and emmetropes.Cross-sectional study.318 subjects including 270 48 emmetropes.195 75 emmetropes participated this study. All had their IOP measured using iCare rebound tonometer while accommodative stimuli 0 D 3 were presented.IOP values without with all subjects. Baseline IOPs compared within between groups.There was no significant difference when...

To investigate the intraocular pressure (IOP) changes after cataract surgery, and its relationship with refractive conditions. IOP phacoemulsification lens (IOL) implantation was retrospectively reviewed. Patients were classified into 3 groups by conditions: emmetropia, mild to moderate myopia, high myopia. Basic information collected including age, sex, place of IOL, operating surgeon, conditions measured before 1, 7, 30, 90 days surgery. The study comprised 353 eyes from patients, which...

Purpose. To analyze the correlations between ocular surface signs and symptoms in patients with dry eye. Methods. In this observational study, 176 eye patients, including 60 males 116 females, were enrolled their observed. Partial correlation analysis was conducted OSDI score each sign, further discussed different age groups. Then multiple linear regression used to explore influence of these on score. Results. Our analyses showed that rounding lid margins, notching vascularity...

To investigate the efficacy of a novel treatment - intra-meibomian gland (MG) injection anti-VEGF agent bevacizumab for MG dysfunction (MGD) with eyelid-margin vascularity.A total 26 eyes from 13 patients diagnosed MGD and vascularity were included in our study. Patients received injections (150 μL, 2.5 mg/0.1 mL) at multiple sites 29 G needle where telangiectasia was severe. The Ocular Surface Disease Index (OSDI), tear film, tear-breakup time (TBUT), features, conjunctiva, corneal staining...

Background: Previous animal studies and clinical trials report inconsistent findings regarding the role of statins in pulmonary hypertension (PH). Systematic reviews have shown no use on arterial (PAH). This is first meta-analysis randomized controlled (RCTs) determining impacts statin therapy patients with PH secondary to lung diseases. Methods: Electronic databases manual bibliographical searches were conducted. Eligible included RCTs at least 3 months that evaluated as compared control...

Abstract Background To investigate the value of Ubiquitin specific peptidase 8 (USP8), Chitinase 3‐like 1 (YKL40), Heat shock protein 90a (HSP90α), glutathione S‐transferase P1 (GSTP1), carcinoembryonic antigen (CEA), neuron enolase (NSE) and cytokeratin fragment antiogen 21‐1 (CYFRA21‐1) in bronchoalveolar lavage fluid (BALF) serum for diagnosis patients with peripheral lung cancer. Methods The concentration these markers were measured 50 cancer benign diseases by using enzyme‐linked immuno...

Clinical outcomes following trifocal diffractive intraocular lens implantation for age-related cataract in China Yang Yang, Huibin Lv, Yuexin Wang, Xiaodan Jiang, Mingzhou Zhang, Xuemin Li Department of Ophthalmology, Peking University Third Hospital, Beijing, Purpose: The aim this study was to evaluate visual, refractive and patient satisfaction a (IOL). Patients methods: This prospective, consecutive included patients undergoing phacoemulsification IOL (AT LISA tri 839MP). Visual outcomes,...

As the leading cause of impaired vision, congenital cataracts, particularly autosomal dominant cataract (ADCC), have been considered as a hereditary disease. The present study aimed to identify genetic defects in Chinese pedigrees with ADCC. A total 6 families ADCC were included, comprising 103 members and 27 patients assessed total. Genomic DNA samples extracted from peripheral blood probands; mutations determined using specific eye disease enrichment panel next-generation sequencing....

Background: Adherence to medication plays an important role in the control of disease progression and treatment costs for patients with chronic obstructive pulmonary (COPD). Existing studies are mostly retrospective based on local medical insurance databases prescription records therefore cannot analyze or determine causes poor adherence COPD patients.

Abstract Purpose As the leading cause of impairment vision children, congenital cataract is considered as a hereditary disease, especially autosomal dominant (ADCC). The purpose this study to identify genetic defect six Chinese families with ADCC. Subjects and Methods Six ADCC were recruited in study. (103 members total, 96 alive, 27 patients total) Genomic DNA samples extracting from probands’ peripheral blood cells captured mutations using specific eye disease enrichment panel next...

The purpose of this study is to summarize the benefits double-deck viscoelastic technique (DDVT), a novel and cost-effective surgical that creates barrier hinder silicone oil (SO) from connecting damaging corneal endothelium in aphakic SO-dependent eyes. Five eyes underwent embedment penetrating keratoplasty (PKP) retrospective case series. At 1, 6, 12, 18, 24 months after surgery, clinical outcomes including best corrected visual acuity (BCVA), intraocular pressure (IOP), endothelial cell...

Abstract Background: Tuberculous pleural effusion (TPE) is one of the most prevalent causes exudative effusion. As it curable, early diagnosis essential. Nevertheless, direct examination not so sensitive while thoracoscopy invasive and resource-demanding. Objective: To seek a less-invasive but also cost-effective substitute for medical to identify TPE. Methods: We retrospectively collected 662 patients with effusions who have undergone as training cohort, developed predictive model then...