Purpose: The purpose of this study was to establish a deep learning model for automated sub-basal corneal nerve fiber (CNF) segmentation and evaluation with in vivo confocal microscopy (IVCM). Methods: A network (CNS-Net) established convolutional neural networks based on algorithm evaluation. CNS-Net trained 552 tested 139 labeled IVCM images as supervision information collected from July 2017 December 2018 Peking University Third Hospital. These were by three senior ophthalmologists ImageJ...

This study aimed to observe corneal subbasal nerves and Langerhans cells (LCs) using in vivo confocal microscopy (IVCM) patients with dry eye, a tool for the evaluation of disease stage severity treatment monitoring at microstructural level.A total 107 eyes from 62 were included. The Ocular Surface Disease Index (OSDI) questionnaire other examinations used assess eye symptoms signs. IVCM was performed LCs. Corneal graded both objective subjective methods. correlations between nerve...

Our study aimed to evaluate the efficiency of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in treating dysfunction (MGD).This was a prospective interventional study. A total 53 patients were included and received series three treatments at an interval 3-4 weeks. Follow-up examinations completed 4 weeks after last treatment. The Ocular Surface Disease Index (OSDI) questionnaire, tear meniscus height (TMH), break-up time (TBUT), slit-lamp examinations, vivo...

Abstract This study aimed to propose a comprehensive grading scale evaluate different clinical manifestations in patients with varying severity of meibomian gland dysfunction (MGD) and analyze the correlations between parameters ocular surface impairment MGD. A total 63 MGD were enrolled. Ten specific symptoms evaluated each subjective score was applied grade Thirty-seven diagnosed mild, 19 moderate, 7 severe Slit-lamp keratography used assess signs (MG). In vivo confocal microscopy (IVCM)...

This study aimed to evaluate the efficacy and safety of a new-generation intense pulsed light (IPL) device in improving symptoms signs meibomian gland dysfunction (MGD)-related dry eye, compare it with traditional IPL device.This multicenter randomized controlled trial enrolled 132 patients MGD-related eye from two centers. Patients were randomly assigned into (Eyesis) group or (E-Eye) group, then blinded receive treatment on days 0 7. Ocular Surface Disease Index (OSDI), tear meniscus...

Purpose: To present a new ocular nebulization therapy for the treatment of dry eye disease (DED) and investigate efficacy vitamin B12 (VB12) oxytocin (OXT) with clinical parameters in vivo confocal microscopy (IVCM). Patients methods: Thirty-eight patients DED were enrolled, 19 receiving VB12 OXT twice weekly 3 months. Clinical signs symptoms including Ocular Surface Disease Index, self-assessment light sensitivity dryness, tear meniscus height, break-up time (BUT), corneal staining, along...

To assess the effects of oral vitamin B1 and mecobalamin on dry eye disease (DED) patient satisfaction with treatment.In this randomized controlled study, DED patients were divided into 4 groups based treatment: group 1, only artificial tears; 2, corticosteroid drops 3, B1, mecobalamin, 4, drops, tears. symptoms, signs, treatment assessed at baseline 1 2 months after total, 152 eyes from 76 (age, 55.25 ± 18.16 years) included. In there significant differences in dryness, foreign body...

Our purpose is to demonstrate the changes in cornea nerve parameters and symptoms signs dry eye disease (DED) patients after oral vitamin B1 mecobalamin treatment. In this randomized double-blind controlled trial, DED were randomly assigned either treatment group (oral mecobalamin, artificial tears) or control (artificial tears). Corneal via vivo confocal microscopy (IVCM), symptoms, assessed at baseline 1 3 months post-treatment. total, 398 eyes from 199 included. group, there significant...

Abstract Purpose To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves quality. Methods Ninety-eight eyes of 49 patients with DED were included. Each patient was evaluated ocular surface disease index (OSDI), eyelid margin signs meibomian gland assessments; staining; tear film breakup time (TBUT); meniscus height (TMH); vivo confocal microscopic (IVCM); including scatter (OSI), mean scattering (mOSI), modulation transfer function (MTF)...

Purpose Less was known about globular cells which were a type of dendritic (DCs) in cornea. We aimed to investigate the morphological and distribution characteristics corneal vortex their clinical correlations with ocular surface. Methods Case records patients who underwent vivo confocal microscopy (IVCM) evaluated retrospectively. The morphology features cornea nerve co-existence status Langerhans (LCs) analyzed. Data surface symptoms signs collected patterns forms performed. Dry eye...

This study aimed to evaluate the change patterns in corneal intrinsic aberrations and nerve density after cataract surgery dry eye disease. The preoperative, 1- 3-month postoperative eye-related parameters were obtained by Oculus keratograph ocular surface disease index questionnaire. measured using Pentacam HR system. In vivo confocal microscopy was performed observe vortical peripheral nerves. An artificial intelligence technique run deep learning model generated parameters. Corneal on...

An 84-year-old woman underwent cataract surgery. In 3 weeks, the right eye presented with blurred vision, corneal irritation and photophobia. After 5 symptoms in worsened ganciclovir was prescribed. Based on clinical findings, viral keratitis suspected; real-time PCR (RT-PCR) assay of tear samples from performed. Thereafter 1 week, left also exhibited similar symptoms. The RT-PCR performed using a sample eye; results suggested presence Epstein–Barr virus cytomegalovirus. A combination...

This study aimed to investigate the association of between previously neglected oval cells located in corneal vortex and dry eye disease (DED). was an observational, prospective involving 168 patients with different degrees DED. In vivo confocal microscopy used observe subbasal nerves Langerhans (LCs) periphery. Bright were also observed vortex. An artificial intelligence technique generate nerve fiber parameters. The divided into three groups based on presence inflammatory cells. Group 2...

Purpose. To comparatively evaluate the safety and satisfaction of bandage contact lens (BCL) eye patching in patients after cataract surgery. Methods. Sixteen (32 eyes) who planned to undergo bilateral surgery were recruited. The two eyes each patient randomly divided into 2 groups. Group A B instructed wear BCLs immediately at end until one week patch day, respectively. Visual analog scales ten specific symptoms, Function Index (VF-14) questionnaire, best-corrected visual acuity (BCVA)...

Purpose The study assessed the validity of impression cytology (IC) and in vivo confocal microscopy (IVCM) lip mucosa compared with labial gland biopsy, anti-Sjögren’s syndrome A (SSA)/Ro antibody status, classification criteria suspected primary Sjögren’s (pSS) patients. Methods Clinically pSS patients (n = 201) were enrolled consecutively divided into 56) control 145, only dryness) groups according to American College Rheumatology-European League Against Rheumatism (ACR-EULAR) criteria....

Background: Labial gland biopsies play a significant role in diagnosing primary Sjogren's syndrome (pSS) but their clinical use is limited because of invasiveness. We assessed the value impression cytology (IC) and vivo confocal microscopy (IVCM) for pSS. Methods: Consecutive patients with clinically suspected pSS (n = 102) were enrolled. According to American College Rheumatology-European League Against Rheumatism (ACR-EULAR) criteria, all underwent labial biopsies, serum anti-Sjogren's A...

Abstract Purpose: To evaluate the change patterns in corneal aberrations and nerve density after cataract surgery dry eye disease (DED). Methods: One hundred six eyes of 69 patients with were included this study. The preoperative, 1-month 3-month postoperative eye-related indices obtained by Oculus keratograph ocular surface index (OSDI) questionnaire. regularity measured using a Pentacam HR system. In vivo confocal microscopy (ICVM) was performed to observe sub-basal nerves vortex superior...

To improve the medical management system and quality of treatment, this study aimed to assess patient satisfaction related an ocular surface individualized program for dry eye, identified needs that should be addressed in future.We enrolled 166 patients from eye clinic at Peking University Third Hospital December 2017 May 2019. An investigator followed up with all by telephone 2 months after first assessment overall satisfaction, expectations, experiences. We determined using a questionnaire...

Abstract Background To investigate the morphological features of corneal subbasal nerve plexus (CSNP) and Langerhans cells (LCs) in normal tension glaucoma (NTG) primary open angle (POAG) Methods Ten eyes with NTG (8 untreated), 23 POAG (9 untreated) 31 healthy subjects were recruited. CSNP LCs assessed by confocal microscopy (CCM) peripapillary retinal fiber layer (RNFL) was measured optical coherence tomography (OCT). CCM parameters including length (FL), branch number (BN), width (NW),...