A5103111212- Chronic Myeloid Leukemia Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Amyotrophic Lateral Sclerosis Research
- Chronic Lymphocytic Leukemia Research
- Alzheimer's disease research and treatments
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Stroke Rehabilitation and Recovery
- Neurogenetic and Muscular Disorders Research
- Ocular Surface and Contact Lens
- Acute Ischemic Stroke Management
- Memory and Neural Mechanisms
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Sleep and Wakefulness Research
- Multiple Myeloma Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Text Readability and Simplification
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
Huashan Hospital
2020-2025
Fudan University
2020-2025
Yingkou Institute of Technology
2024
Peking University
2006-2023
Osaka University
2020-2023
Peking University Third Hospital
2019-2023
Osaka Health Science University
2020-2023
Chinese University of Hong Kong, Shenzhen
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Zhejiang University
2019-2022
Cerebral amyloid angiopathy (CAA) is characterized by β-amyloid deposition in cortical and leptomeningeal arterioles, which might result from glymphatic dysfunction. The aim was to explore function CAA using the non-invasive diffusion tensor image analysis along perivascular space method.Sixty-three patients with were prospectively recruited together seventy age- sex-matched normal controls. Mini-Mental State Examination Montreal Cognitive Assessment applied screen global cognitive status....
The aim of this study was to investigate the prevalence temporomandibular disorders (TMD) symptoms and their association with sleep quality psychological distress in Chinese adolescents.Five hundred seventy-eight adolescents were enrolled completed a self-reported TMD symptom questionnaire socio-demographics survey. Sleep assessed. Descriptive statistics logistic regression analysis performed as outcome variable.The at least one 61.4%. One-third subjects experienced disturbed sleep,...
Abstract The amygdala, which is involved in various behaviors and emotions, reported to connect with the whole brain. However, long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus generate whole-brain map main mouse amygdala. We identified 37 individual regions that projected neurons expressing vesicular glutamate transporter 2, 78 parvalbumin-expressing neurons, 104 protein kinase C-δ, 89 somatostatin-expressing neurons....
Limitations in cell proliferation are important for normal function of differentiated tissues and essential the safety replacement products made from pluripotent stem cells, which have unlimited proliferative potential. To evaluate whether these limitations can be established pharmacologically, we exposed pancreatic progenitors differentiating human cells to small molecules that interfere with cycle progression either by inducing G1 arrest or impairing S phase entry completion determined...
Chimeric antigen receptor (CAR) T-cell immunotherapy still faces many challenges in the treatment of solid tumors, one which is dysfunction or exhaustion. Immunomodulator lenalidomide may improve CAR function. In this study, effects on functions (cytotoxicity, cytokine secretion, and cell proliferation) were investigated. Two different T cells (CD133-specific HER2-specific CAR) prepared, corresponding target including human glioma line U251 CD133-OE that overexpress CD133 breast cancer...
Background:Flortaucipir (AV-1451) and pyridinyl-butadienyl-benzothiazole 3 (PBB3) are newly developed commonly used positron emission tomography (PET) tracers to detect tau deposition in tauopathies, including frontotemporal dementia (FTD). [18F]PM-PBB3, as a second-generation compound, has not been described FTD so far. Objective:We aim explore the vivo performance of [18F]PM-PBB3 PET an case caused by microtubule-associated protein (MAPT) mutation compare binding different strains between...
We systematically characterized plasma protein profiles in cerebral amyloid angiopathy (CAA) using proteomics and identified a hub panel for disease diagnosis risk stratification. A total of 146 patients with probable CAA 128 community-dwelling controls were prospectively enrolled. Plasma samples underwent proteomic analysis, the proteins validated two validation cohorts. Machine learning algorithms applied to construct validate performance circulating panel. 166 differentially expressed...
ABSTRACT Aim Diabetes‐associated cognitive impairment (DACI) is a common complication of Type 2 diabetes mellitus (T2DM), with its mechanisms and treatments for DACI remaining incompletely clarified. This study investigated the protective efficacy novel lipid S‐enantiomer 9‐palmitic acid esters hydroxy stearic acids (S‐9‐PAHSA, S9P) in high‐fat diet‐induced mouse model. Methods Mice were randomly assigned to three groups: normal diet (ND), (HFD), HFD + 30 mg/kg/day S9P (HFD S9P). Fasting...
Predicting recurrent intracerebral hemorrhage (ICH) related to cerebral amyloid angiopathy (CAA) currently relies on brain images.We aimed investigate whether blood neurodegenerative biomarkers predict disease severity and ICH recurrence in CAA.We recruited 68 first probable CAA-ICH cases from a Chinese prospective cohort, 95 controls.We used the single-molecule array measure acute phase amyloid-40, amyloid-42, total tau neurofilament light chain (NfL).We multivariable Cox regression models...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with progressive motor system impairment, and recent evidence has identified the extra-motor involvement. Small fiber neuropathy reflecting by sensory autonomic disturbances in ALS been reported to accompany damage. However, non-invasive assessment of this impairment its application disease evaluation scarce. We aim evaluate use corneal confocal microscopy (CCM) non-invasively quantify small explore...
Abstract This study aimed to propose a comprehensive grading scale evaluate different clinical manifestations in patients with varying severity of meibomian gland dysfunction (MGD) and analyze the correlations between parameters ocular surface impairment MGD. A total 63 MGD were enrolled. Ten specific symptoms evaluated each subjective score was applied grade Thirty-seven diagnosed mild, 19 moderate, 7 severe Slit-lamp keratography used assess signs (MG). In vivo confocal microscopy (IVCM)...
Methyl-CpG-binding protein 2 (MeCP2) encoded by the MECP2 gene is a transcriptional regulator whose mutations cause Rett syndrome (RTT). Mecp2-deficient mice show fear regulation impairment; however, cellular and molecular mechanisms underlying this abnormal behavior are largely uncharacterized. Here, we showed that Mecp2 deficiency in cholinergic interneurons of nucleus accumbens (NAc) dramatically impaired learning. We further found spontaneous activity decreased, mediated enhanced...
Background: Neuroinflammation is a major cause of secondary brain injury in intracerebral hemorrhage (ICH). To date, the prognostic value YKL-40 (chitinase-3-like-1 protein), biomarker neuroinflammation, cerebral amyloid angiopathy-related (CAA-ICH) remains undiscovered. Objective: evaluate relationships between serum and CAA-ICH recurrence. Methods: Clinical imaging information 68 first-onset probable cases 95 controls were collected at baseline. Serum was measured by Luminex assay. Cox...
Purpose: To present a new ocular nebulization therapy for the treatment of dry eye disease (DED) and investigate efficacy vitamin B12 (VB12) oxytocin (OXT) with clinical parameters in vivo confocal microscopy (IVCM). Patients methods: Thirty-eight patients DED were enrolled, 19 receiving VB12 OXT twice weekly 3 months. Clinical signs symptoms including Ocular Surface Disease Index, self-assessment light sensitivity dryness, tear meniscus height, break-up time (BUT), corneal staining, along...
Ovarian cancer is the most lethal type of gynecological cancer. Due to its high heterogeneity and complicated pathological mechanisms, 5‑year survival rate patients with ovarian <40%. Tumor cytoreductive surgery systemic chemotherapy platinum combined paclitaxel are currently considered gold standard for treatment cancer, resistance has become a key constraint in improving cure Therefore, it important identify novel methods strategies Targeted drugs can not only be used combination...
The aim was to determine the transitional patterns in clinical characteristics, treatments and comorbidities amyotrophic lateral sclerosis (ALS) patients over past 14 years using data from a large cohort mainland China.Sporadic ALS who visited Peking University Third Hospital January 2005 December 2018 were included this study. divided into three periods, changes baseline characteristics of participants analyzed at 5-year intervals.In total, 3410 with sporadic recruited: 2181 men 1229 women....
BackgroundDaratumumab is approved for relapsed or refractory multiple myeloma (RRMM) as monotherapy in combination regimens. We evaluated daratumumab plus cetrelimab, a programmed death receptor-1 inhibitor, RRMM.Patients and MethodsThis open-label, multiphase study enrolled adults with RRMM ≥ 3 prior lines of therapy. Part 1 was safety run-in phase examining dose-limiting toxicities (16 mg/kg intravenously weekly cycles 1-2, biweekly 3-6, monthly thereafter) cetrelimab (240 mg biweekly, all...
Introduction: Alterations in the visual pathway involving retina have been reported amyotrophic lateral sclerosis (ALS) but they lack consistency and subgroup analysis. We aimed to assess retinal nerve fiber layer (RNFL) ganglion cells (RGCs) alterations different stages of ALS patients their association with progression parameters. Methods: The study population consisted 70 clinically diagnosed 55 age, sex matched controls. All them underwent ophthalmic assessments optical coherence...