A5090925632- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Pain Management and Placebo Effect
- Effects and risks of endocrine disrupting chemicals
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Vestibular and auditory disorders
- Gut microbiota and health
- Toxic Organic Pollutants Impact
- Hearing, Cochlea, Tinnitus, Genetics
- Acupuncture Treatment Research Studies
- Heavy Metal Exposure and Toxicity
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2008-2025
Southern Medical University
2014-2024
LabCorp (United States)
2024
Nanfang Hospital
2022-2023
Guizhou University
2022
Zhujiang Hospital
2014-2021
Zhejiang University
2012-2019
Xi'an Jiaotong University
2017
Penn State Milton S. Hershey Medical Center
2016
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations noted in patients and animal models. However, whether astrocyte dysfunction causal or consequential to ASD-like phenotypes mice unresolved. Type 2 inositol 1,4,5-trisphosphate 6 receptors (IP3R2)-mediated Ca2+ release from intracellular stores results the activation of astrocytes. Mutations IP3R2 gene associated with ASD. Here, we show that both IP3R2-null...
Abstract Background Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments for core autistic symptoms are currently limited. Increasing evidence, particularly that from clinical studies on ASD patients, suggests functional link between gut microbiota development of ASD. However, mechanisms linking with brain dysfunctions (gut-brain axis) in have not yet been full elucidated. Due to its genetic mutations downregulated expression patients ASD,...
Anxiety-related disorders can be treated by cognitive therapies and transcranial magnetic stimulation, which involve the medial prefrontal cortex (mPFC). Subregions of mPFC have been implicated in mediating different even opposite roles anxiety-related behaviors. However, precise causal targets these top-down connections among diverse possibilities not established. Here, we show that lateral septum (LS) central nucleus amygdala (CeA) represent 2 direct infralimbic (IL), a subregion modulates...
Sustained endoplasmic reticulum (ER) stress has been linked to cell death and the pathogenesis of many liver diseases, including toxic liver, cholestasis, infectious disease. The cellular pathways that attenuate hepatic ER have focus recent studies, but role microRNAs (miRNA) in this process remains unknown. Here, we report one most abundant miRNAs hepatocytes, miR-199a-5p, was elevated both bile acid- thapsigargin (TG)-stimulated cultured as well duct-ligated mice. We identify misfolded...
Abstract Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic (DHA). However, the impact of EPA DHA supplementation on normal cognitive function molecular targets are still unknown. We show that acute administration impairs learning memory hippocampal LTP adult prepubescent mice. Similar deficits duplicated by endogenously elevating hippocampus transgenic fat-1...
Disturbed development of the parvalbumin-positive fast-spiking (FS) interneurons in prefrontal cortex (PFC) is closely associated with many neuropsychiatric disorders such as schizophrenia and autism. FS form at least 2 microcircuits PFC: one pyramidal neurons (FS–PN) through chemical synapses; other (FS–FS) via electrical synapses. It currently unknown when how these circuits are established PFC during early development. Here, we used G42 mice, which specifically labeled enhanced green...
erbb4 is a susceptibility gene for schizophrenia and ErbB4 signals have been hypothesized to function in number of cortical developmental processes (Silberberg et al., 2006; Mei Xiong, 2008). Several recent studies show that the expression mainly restricted GABAergic interneurons (Yau 2003; Woo 2007), specifically, parvalbumin-positive (PV) fast-spiking (FS) (Vullhorst 2009; Fazzari 2010), large majority which are PV FS basket cells (Kawaguchi, 1995; Taniguchi 2013). However, medial...
Abstract The mechanisms of anxiety disorders, the most common mental illness, remain incompletely characterized. ventral hippocampus (vHPC) is critical for expression anxiety. However, current studies primarily focus on vHPC neurons, leaving role astrocytes in largely unexplored. Here, genetically encoded Ca 2+ indicator GCaMP6m and vivo fiber photometry calcium imaging are used to label monitor their activity, respectively, genetic chemogenetic approaches inhibit activate astrocytes,...
Transient forebrain ischemia induces delayed, selective neuronal death in the CA1 region of hippocampus. The underlying molecular mechanisms are as yet unclear, but it is known that activation L-type Ca 2+ channels specifically increases expression a group genes required for survival. Accordingly, we examined temporal changes calcium-channel activity and CA3 pyramidal neurons rat hippocampus after transient by patch-clamp techniques. In vulnerable neurons, -channel was persistently...
Abstract Post stroke depression (PSD) is a serious complication of stroke. Brain imaging an important method studying the mechanism PSD. However, few studies have focused on single lesion location. The aim this study was to investigate brain frontal lobe PSD using combined voxel-based morphometry (VBM) and functional magnetic resonance (fMRI). In total, 30 first-time ischemic patients underwent T1 weighted MRI resting-state fMRI scans. Clinical assessments included 24-item Hamilton Rating...
Drugs acting on dopamine D2 receptors are widely used for the treatment of several neuropsychiatric disorders, including schizophrenia and depression. Social deficits a core symptom these disorders. Pharmacological manipulation (Drd2), Gi-coupled subtype receptors, in medial prefrontal cortex (mPFC) has shown that Drd2 is implicated social behaviors. However, type neurons expressing mPFC underlying circuit mechanism regulating behaviors remain largely unknown. Here, we show were mainly...