<title>Abstract</title> Purpose Rapid identification of pathogenic bacteria in the vitreous and/or aqueous humor patients with acute clinical diagnosis endophthalmitis via nanopore sequencing technology. Methods We recruited a total 12 (12 eyes) who were diagnosed at an ophthalmic outpatient clinic from January 2022 to October 2022. Clinical evaluation is conducted order consultation, symptom evaluation, physical sign and special examination, all which are completed by same experienced...

Abstract We evaluated how different degrees of air pollution affect the ocular surface a cohort human subjects in Beijing by correlating in-patient test outcomes with tear cytokines. A cross-sectional study involving 221 volunteers was carried out districts Beijing. Air indices were recorded for 7 d (including visit day). The quality index (AQI), which is dimensionless measure that quantitatively describes state quality, concentrations particulate matter smaller than 2.5 μm (PM2.5) and 10...

Our purpose is to demonstrate the changes in cornea nerve parameters and symptoms signs dry eye disease (DED) patients after oral vitamin B1 mecobalamin treatment. In this randomized double-blind controlled trial, DED were randomly assigned either treatment group (oral mecobalamin, artificial tears) or control (artificial tears). Corneal via vivo confocal microscopy (IVCM), symptoms, assessed at baseline 1 3 months post-treatment. total, 398 eyes from 199 included. group, there significant...

Purpose To investigate binocular dynamic visual acuity (DVA) for patients with dry eye disease (DED). Methods The prospective study included DED patients. DVA at 40 and 80 degrees per second (dps), Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), film break-up time first (TBUTF), corneal fluorescein staining (CFS), eyelid margin abnormalities meibomian gland (MG) morphology function were evaluated. A deep learning model was applied to quantify the MG area proportion....

Purpose To explore the composition of ocular microbiome in patients with Meibomian gland dysfunction (MGD) using metagenomic nanopore sequencing. Methods A total 98 participants were recruited from September to December 2021, including 86 MGD and 12 controls. Symptoms signs dry eye assessed, bacterial samples conjunctival sac (CS) meibomian (MG) secretions then identified by culture identification Results The positive rate CS group was significantly higher than that normal group. more...

Purpose Less was known about globular cells which were a type of dendritic (DCs) in cornea. We aimed to investigate the morphological and distribution characteristics corneal vortex their clinical correlations with ocular surface. Methods Case records patients who underwent vivo confocal microscopy (IVCM) evaluated retrospectively. The morphology features cornea nerve co-existence status Langerhans (LCs) analyzed. Data surface symptoms signs collected patterns forms performed. Dry eye...

This study aimed to evaluate the change patterns in corneal intrinsic aberrations and nerve density after cataract surgery dry eye disease. The preoperative, 1- 3-month postoperative eye-related parameters were obtained by Oculus keratograph ocular surface disease index questionnaire. measured using Pentacam HR system. In vivo confocal microscopy was performed observe vortical peripheral nerves. An artificial intelligence technique run deep learning model generated parameters. Corneal on...

This study aimed to investigate the association of between previously neglected oval cells located in corneal vortex and dry eye disease (DED). was an observational, prospective involving 168 patients with different degrees DED. In vivo confocal microscopy used observe subbasal nerves Langerhans (LCs) periphery. Bright were also observed vortex. An artificial intelligence technique generate nerve fiber parameters. The divided into three groups based on presence inflammatory cells. Group 2...

Objectives. To investigate the effect of 2% hydroxypropyl methylcellulose (HPMC) and bandage contact lens (BCL) on dry eye disease after cataract surgery. Methods. This prospective randomized controlled trial included 63 eyes which were divided into balanced salt solution (BSS), HPMC, BCL, combined HPMC BCL (H&amp;B) groups. The Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), average break-up time measured before surgery 30 days postoperatively. Differences in corneal nerve...

Purpose. To comparatively evaluate the safety and satisfaction of bandage contact lens (BCL) eye patching in patients after cataract surgery. Methods. Sixteen (32 eyes) who planned to undergo bilateral surgery were recruited. The two eyes each patient randomly divided into 2 groups. Group A B instructed wear BCLs immediately at end until one week patch day, respectively. Visual analog scales ten specific symptoms, Function Index (VF-14) questionnaire, best-corrected visual acuity (BCVA)...

Abstract Purpose: To evaluate the change patterns in corneal aberrations and nerve density after cataract surgery dry eye disease (DED). Methods: One hundred six eyes of 69 patients with were included this study. The preoperative, 1-month 3-month postoperative eye-related indices obtained by Oculus keratograph ocular surface index (OSDI) questionnaire. regularity measured using a Pentacam HR system. In vivo confocal microscopy (ICVM) was performed to observe sub-basal nerves vortex superior...

Extranodal natural killer/T-cell lymphoma (ENKL) usually occurs in the nose or nasopharynx, but extranasal and disseminated disease can occur. In this disease, orbital involvement is more commonly seen, without nasal rare. A 61-year-old woman was referred with a one-month history of remarkably enlarging salmon-colored mass arising right inner canthus, redness painlessness. The motility eye limited medial direction, external deviation eyeball. magnetic resonance imaging (MRI) scan orbits...

Abstract Background To investigate the morphological features of corneal subbasal nerve plexus (CSNP) and Langerhans cells (LCs) in normal tension glaucoma (NTG) primary open angle (POAG) Methods Ten eyes with NTG (8 untreated), 23 POAG (9 untreated) 31 healthy subjects were recruited. CSNP LCs assessed by confocal microscopy (CCM) peripapillary retinal fiber layer (RNFL) was measured optical coherence tomography (OCT). CCM parameters including length (FL), branch number (BN), width (NW),...

A 52-year-old patient was initially diagnosed as hypophosphatemic osteomalacia in the Department of Endocrinology due to knee, foot and lumbosacral pain. The symptoms were not significantly relieved after phosphorus vitamin D supplementation. Later, imaging examination showed an orbital tumor right eye. surgically removed, systemic bone pain relieved.1例52岁患者初期因双膝、双足及腰骶疼痛，就诊于内分泌科诊断为低磷性骨软化症。给予补磷、补维生素D治疗，症状未见明显缓解。其后影像学检查发现右眼眶肿物，通过手术切除眼眶肿瘤，患者全身骨痛症状缓解。.

Purpose: This study aimed to determine the relationship between dry eye-related symptoms and signs, including meibomian gland corneal nerves parameters, anxiety depression. Methods: In this observational study, we recruited 63 volunteers, 51 patients with eye disease (DED) 12 healthy volunteers. The tear meniscus height (TMH), film break-up time (TBUT), infrared images of nerve layer analysis all were assessed. Additionally, completed Hospital Anxiety Depression Scale (HADS) questionnaire,...

The biological characteristics of Fusarium solani clinical corneal isolates growing in different nutritional conditions vitro were studied order to find out the key point pathogenicity. Five kinds media with glucose and nitrogen concentrations prepared as liquid solid forms. follows: 2 strains. standard strains inoculated media. They all incubated at 296 for 96 h observed defined time points. optical density was recorded generate growth curves Morphologic changes colonies determined under...

Abstract To investigate association of a type previously neglected oval cell that located in corneal vortex with dry eye disease (DED). Observational, prospective study 168 patients different degrees DED. In vivo confocal microscopy was used to observe the sub-basal nerves and Langerhans cells (LCs) both periphery. The bright also be inspected vortex. An artificial intelligence (AI) technique generated nerve fibre parameters. Patients were divided into three groups based on existence...