- Angiogenesis and VEGF in Cancer
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Hydrogen's biological and therapeutic effects
- Electrospun Nanofibers in Biomedical Applications
- Metabolism, Diabetes, and Cancer
- Bone and Dental Protein Studies
- Heart Failure Treatment and Management
- Advanced Nanomaterials in Catalysis
- Ion Channels and Receptors
- Tissue Engineering and Regenerative Medicine
- Atrial Fibrillation Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cancer, Stress, Anesthesia, and Immune Response
- Kruppel-like factors research
- TGF-β signaling in diseases
- Bioactive Compounds and Antitumor Agents
- Flavonoids in Medical Research
- Medicinal Plants and Bioactive Compounds
- FOXO transcription factor regulation
Army Medical University
2011-2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Xinqiao Hospital
2010-2022
Chongqing University
2016
Creative Commons
2015
May Institute
2015
Nanyang Medical College
2001
Endothelial progenitor cells (EPCs) play an important role in accelerating endothelial repair after vascular injury. The proliferation and migration of EPCs is a critical first step restoring endothelial. However, mechanisms for modulating EPC are still being elucidated. Our previous study found that transient receptor potential canonical-1 (TRPC1) involved regulating store-operated Ca(2+) entry through stromal interaction molecule 1. Therefore, the present study, we sought to further...
Cardiac stem cells (CSCs) can home to the infarcted area and regenerate myocardium. Stromal cell-derived factor-1α/C-X-C chemokine receptor type 4 (SDF-1α/CXCR4) axis is pivotal in inducing CSCs migration. However, mechanisms remain unclear. This study set out detect if SDF-1α promotes migration engraftment of through CXCR4/PI3K (phosphatidylinositol 3-kinase) pathway. In vitro experiment, c-kit+ were isolated from neonatal mouse heart fragment culture by magnetic cell sorting....
Abstract Background Aging is believed to have a close association with cardiovascular diseases, resulting in various pathological alterations blood vessels, including vascular cell phenotypic shifts. In aging the microRNA(miRNA)-mediated mechanism regulating smooth muscle (VSMC) phenotype remains unclarified. MiRNA microarray was used compare expressions of miRNAs VSMCs from old rats (oVSMCs) and young (yVSMCs). Quantitative reverse transcription real-time PCR (qRT-PCR) small RNA...
Synthetic small-diameter vascular grafts are of limited use mainly due to the lack endothelial cells (ECs), which inhibit intraluminal thrombosis and intimal hyperplasia. Grafts loaded with homing factors for circulating progenitor (EPCs) have potential achieve in situ endothelialization. In view important role that EPCs play construction artificial blood vessels, antioxidant therapy aiming oxidative stress-induced EPC apoptosis should be focus clinical interest. this study, polyethylene...
Vibration syndrome caused by hand-held vibrating tools in 14 locomotive and rolling stock plants four regions of the People's Republic China (south, north, middlewest, northeast) influence climatic factors on its prevalence rate were studied. For 1,028 male workers (705 riveters, 284 chippers, 39 grinders), was 13.4% for a reference group 256 it 1.6%. The white finger differed higher northeast north than south middlewest China. This finding suggests that cold climate humidity may be...
The purpose of the present study was to determine whether using hydrogen-rich medium (HRM) increase hydrogen levels in endothelial cells (ECs) protects ECs from apoptosis induced by advanced glycation end products (AGEs). thoracic aorta removed 2-3-year-old Sprague-Dawley rats, and were isolated cultured. After culturing presence AGEs and/or with HRM for 24 h, Annexin V/7-AAD TUNEL staining carried out detect apoptosis. Intracellular ROS detected fluorescent probe quantified flow cytometry....
Endothelial progenitor cell (EPC) therapy represents a novel strategy for variety of diseases. Interestingly, spleen acts an important reservoir during EPC trafficking. Therefore, we investigated the involvement stromal cell-derived factor-1 (SDF-1)/CXCR4 in settlement spleen. were cultured and characterized as previous methods. Then, 1 × 106 labeled with DiI-LDL intravenously infused into C57/BL6 mice. Immunohistochemical staining showed homing transplanted 24 h later, indicating...
Appetite loss is a common symptom that occurs in high altitude (HA) for lowlanders. Previous studies indicated hypoxia the initiating vital factor of HA appetite loss. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 play important roles hypoxic responses. We aimed to explore association these hypoxia-related gene polymorphisms with In this study, we enrolled 416 young men who rapidly ascended Lhasa (3700 m) from Chengdu (<500m) by plane. were genotyped MassARRAY. scores measured identify...
Transcatheter aortic valve replacement (TAVR) in the treatment of patients with pure native regurgitation (NAVR) has been based on "off-label" indications, while absence calcification and difficulty anchoring was found to significantly increase risk prosthesis malposition. The aim this study explore anatomical predictors severe malposition following TAVR self-expandable Venus-A Valve among NAVR.A total 62 NAVR who underwent at four Chinese clinical centers were retrospectively observed....
Background: Previous animal studies and clinical trials report inconsistent findings regarding the role of statins in pulmonary hypertension (PH). Systematic reviews have shown no use on arterial (PAH). This is first meta-analysis randomized controlled (RCTs) determining impacts statin therapy patients with PH secondary to lung diseases. Methods: Electronic databases manual bibliographical searches were conducted. Eligible included RCTs at least 3 months that evaluated as compared control...
BACKGROUND: The aim of this study is to explore the role atorvastatin in rescuing pulmonary artery hypertension (PAH) by inhibiting AKT/ERK-dependent PDGF-BB/HIF-1α axis.METHODS: PAH model rats was established MCT induction, followed Atorvastatin intervention. Pulmonary hemodynamic measurement and morphological evaluation were conducted. Human smooth muscle cells (hPASMCs) subjected hypoxic exposure or PDGF-BB treatment, induction. Relative levels HIF-1α, p-ERK p-Akt detected. Viability...