A5102012101- High Altitude and Hypoxia
- Spine and Intervertebral Disc Pathology
- Neuroscience of respiration and sleep
- Aquaculture Nutrition and Growth
- Physiological and biochemical adaptations
- Aquaculture disease management and microbiota
- Medical Imaging and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Heart Rate Variability and Autonomic Control
- Cervical and Thoracic Myelopathy
- Orthopaedic implants and arthroplasty
- Reproductive biology and impacts on aquatic species
- Adipose Tissue and Metabolism
- Travel-related health issues
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- Ichthyology and Marine Biology
- Connective tissue disorders research
- Identification and Quantification in Food
- Osteoarthritis Treatment and Mechanisms
- Mitochondrial Function and Pathology
- Regulation of Appetite and Obesity
Ministry of Agriculture and Rural Affairs
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2016-2025
Chinese Academy of Fishery Sciences
2014-2025
Jinzhou Medical University
2025
Tangshan Gongren Hospital
2024
Second Affiliated Hospital of Harbin Medical University
2024
Inner Mongolia Agricultural University
2024
Harbin Medical University
2024
China Academy of Chinese Medical Sciences
2022
This study aimed to investigate the effects of luteolin on colorectal cancer (CRC) and explore its underlying mechanism. HCT-116 HT-29 cells were treated with luteolin, cisplatin, or selumetinib. The cell survival, proliferation, apoptosis cycle distribution, DNA damage detected using Cell Counting Kit-8, colony formation, flow cytometry, immunofluorescence staining analysis, respectively. Western blotting was used detect expression apoptosis-related, cycle-related, DNA-damage-related,...
This double-blind, randomized controlled trial aimed to investigate inhaled budesonide and oral dexamethasone compared with placebo for their prophylactic efficacy against acute mountain sickness after high-altitude exposure.There were 138 healthy young male lowland residents recruited randomly assigned receive (200 μg, twice a day [bid]), (4 mg, bid), or (46 in each group). They traveled 3900 m altitude from 400 by car. Medication started 1 before exposure continued until the third of...
Abstract This paper discusses the possibility of using sorbic acid‐chitosan microcapsules (S‐MPs) as an antibacterial component active ethylene vinyl alcohol copolymer (EVOH) film. S‐MPs with a diameter approximately 1 to 4 μm showed acid loading capacity 46.5%. Addition (3%, w/w) increased tensile strength, haze, oxygen, and water vapor barrier properties, well reduced elongations at break transmittance S‐MPs‐EVOH (S‐MP‐EVOH) Antibacterial tests that inhibitory S‐MP‐EVOH film against...
We previously reported that genistein, a phytoestrogen, up-regulates endothelial nitric oxide synthase (eNOS) and prevents hypertension in rats are independent of estrogen signaling machinery. However, how genistein regulates eNOS expression is unknown. In the present study, we show enhanced NO synthesis primary human aortic cells. Inhibition extracellular signal regulated kinase, phosphoinositol-3 or protein kinase C did not affect genistein-enhanced synthesis. chemical inhibition A (PKA)...
Abstract Background This prospective and observational study aimed to identify demographic, physiological psychological risk factors associated with high-altitude headache (HAH) upon acute exposure. Methods Eight hundred fifty subjects ascended by plane 3700 m above Chengdu (500 m) over a period of two hours. Structured Case Report Form (CRF) questionnaires were used record demographic information, examinations, scale, symptoms including insomnia week before ascending within 24 hours after...
Background: Alzheimer's Disease (AD) affects millions of elderly individuals worldwide and has been clinically recognized as one the most significant disorders compromising quality life in late-stage human development. The objective this study is to systematically evaluate influence holistic nursing (HN) on patients with AD, thereby providing evidence-based references for clinical practice. Methods: A total 105 AD hospitalized our hospital between January 2023 2024 were enrolled prospective...
Background: The aim of this study was to explore the relationship between age and acute mountain sickness (AMS) when subjects are exposed suddenly high altitude. Methods: A total 856 young adult men were recruited. Before after altitude exposure, Athens Insomnia Scale score (AISS) used evaluate subjective sleep quality subjects. AMS assessed using Lake Louise scoring system. Heart rate (HR) arterial oxygen saturation (SaO 2 ) measured. Results: Results showed that, at 500 m, AISS insomnia...
Sleep disturbances and psychiatric repercussions pose great challenges at high altitude; however, few studies have investigated sleep disturbance anxiety profiles their associations after acute exposure in consecutive patients. Thus, we aimed to study the of patients high-altitude association such with anxiety. A total 668 participants were recruited sea level 3700 m. The trials performed (1 week prior a 2-h flight destination) m (24, 72, 168 h). assessed by self-reported patterns scores on...
Metabolic capacity is intrinsic to growth performance. To investigate superior performance in Nile tilapia, three full-sib families were bred and compared at the biochemical transcriptome levels determine metabolic mechanisms involved significant differences between individuals under same culture environment feeding regime. Biochemical analysis showed that higher group had significantly total protein, triglyceride, cholesterol, high- low-density lipoproteins, but lower glucose, as with...
Trimetazidine (TMZ) has been shown to optimize myocardial energy metabolism and is a common anti-ischemic agent. Our trial (ChiCTR-TRC-13003298) aimed explore whether TMZ any preventive effect on high-altitude fatigue (HAF), cardiac function cardiorespiratory fitness upon acute exposure how it works HAF. Thirty-nine healthy young subjects were enrolled in randomized double-blinded placebo-controlled take oral (n = 20) or placebo 19), 20 mg tid, 14 days prior departure until the end of study....
To investigated the objective indicators and potential genotypes for acute mountain sickness (AMS). 176 male subjects were evaluated symptoms scores physiological parameters at 3700 m. EPAS1 gene polymorphisms explored verified effects of on pulmonary function by inhaled budesonide. The incidence AMS was 53.98% (95/176). individuals who suffered from headache with anxiety greater changes in heart rate (HR), forced vital capacity (FVC), mean flow velocity basilar artery (Vm-BA), all which...
Aim We aimed to identify clinical characteristics and risk factors associated with onset of high-altitude headache (HAH) after acute exposure at 3700 m. Method In two hours, 163 individuals ascended by plane Demographic information, physiological psychological measurements, cognitive function, physical work capacity tests profile mood states within one week prior the departure 24 hours arrival were examined. Results HAH patients featured significantly higher vertebral artery diastolic...
This study aimed to identify the systemic and cerebral hemodynamic characteristics their roles in high-altitude headache (HAH) among young Chinese men following acute exposure.The subjects (n = 385) were recruited June July of 2012. They completed case report form questionnaires, as well heart rate (HR), blood pressure, echocardiogram transcranial Doppler examinations at 3700 m a two-hour plane flight. A subgroup 129 participants was examined two altitudes (500 m).HAH characterized by...
The endothelial PAS domain protein 1 (EPAS1) gene functions to sense the blood oxygen level by regulating hypoxia‑inducible transcription factor pathway, and single nucleotide polymorphisms (SNPs) of EPAS1 have been found a strong positive selection in adaptation native Tibetan highland population high‑altitude hypoxia. aim present study was investigate effect SNPs on risk acute mountain sickness (AMS) physiological responses hypoxia lowland humans. Three tag (rs6756667, rs13419896...
Appetite loss is a common symptom that occurs in high altitude (HA) for lowlanders. Previous studies indicated hypoxia the initiating vital factor of HA appetite loss. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 play important roles hypoxic responses. We aimed to explore association these hypoxia-related gene polymorphisms with In this study, we enrolled 416 young men who rapidly ascended Lhasa (3700 m) from Chengdu (<500m) by plane. were genotyped MassARRAY. scores measured identify...
The development of mechanically active culture systems helps in understanding the role mechanical stress intervertebral disc (IVD) degeneration. Motion segment cultures facilitate application and control loads. purpose this study was to establish a culturing method for rabbit IVD motion segments observe effect static load on whole organ. Segments were cultured custom-made apparatuses under constant, compressive (3 kg) 2 weeks. Tissue integrity, matrix synthesis, gene expression profile...
Hybrid tilapia were produced from hybridization of Nile (Oreochromis niloticus) and blue (O. aureus). Comparative transcriptome analysis was carried out on the liver hybrid their parents by RNA sequencing. A total 2319 differentially expressed genes (DEGs) identified. Trend co-expression showed that non-additive gene expression accounted for 67.1% all DEGs. Gene Ontology KEGG enrichment analyses classified respective functional indicated most up-regulated genes, such as FASN, ACSL1, ACSL3,...