A5005940399- Esophageal Cancer Research and Treatment
- Chemokine receptors and signaling
- Lung Cancer Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
Tianjin Medical University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2025
Sichuan Cancer Hospital
2012-2023
University of Electronic Science and Technology of China
2023
A consensus treatment strategy for esophageal squamous cell carcinoma (ESCC) patients who recur after definitive radiochemotherapy/radiotherapy has not been established. This study compared the outcomes in ESCC underwent salvage surgery, chemoradiation (CRT) or best supportive care (BSC) local recurrence. Ninety-five with clinical stage I to III had completely responded initial radiochemotherapy radiotherapy alone and developed recurrence were enrolled this study. Fifty-one of them received...
Abstract Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles and mechanism bone marrow stromal cells (BMSCs) in regulating ferroptosis MM remain elusive. Here, we uncovered that were more susceptible ferroptotic induction under the interaction BMSCs using vitro vivo models. Mechanistically, elevated iron level cells, thereby activating steroid biosynthesis pathway, especially production lanosterol, major source reactive...
In multiple myeloma (MM), bone marrow stromal cells (BMSC) shape a unique niche within the marrow, promoting T-cell dysfunction and driving MM progression; however, precise underlying mechanisms remain elusive. Here, we show that BMSC-mediated reprogramming of led to heightened production CXCL10. CXCL10 orchestrated recruitment γδ T into this was observed in both Vk*MYC 5TGM1 mouse models MM, as well patients experiencing refractory or relapsed MM. Furthermore, dysfunctional exhibited...
<div>Abstract<p>In multiple myeloma (MM), bone marrow stromal cells (BMSC) shape a unique niche within the marrow, promoting T-cell dysfunction and driving MM progression; however, precise underlying mechanisms remain elusive. Here, we show that BMSC-mediated reprogramming of led to heightened production CXCL10. CXCL10 orchestrated recruitment γδ T into this was observed in both Vk*MYC 5TGM1 mouse models MM, as well patients experiencing refractory or relapsed MM. Furthermore,...
<p>supplementary figures and legends</p>
<p>supplementary figures and legends</p>
<div>Abstract<p>In multiple myeloma (MM), bone marrow stromal cells (BMSC) shape a unique niche within the marrow, promoting T-cell dysfunction and driving MM progression; however, precise underlying mechanisms remain elusive. Here, we show that BMSC-mediated reprogramming of led to heightened production CXCL10. CXCL10 orchestrated recruitment γδ T into this was observed in both Vk*MYC 5TGM1 mouse models MM, as well patients experiencing refractory or relapsed MM. Furthermore,...