A5047479260- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Diagnosis and treatment of tuberculosis
- Microbial Natural Products and Biosynthesis
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Tuberculosis
- Lung Cancer Treatments and Mutations
- Airway Management and Intubation Techniques
- Bacterial Genetics and Biotechnology
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Tuberous Sclerosis Complex Research
- Peptidase Inhibition and Analysis
- Medical Imaging and Analysis
- Bacterial biofilms and quorum sensing
- Congenital Diaphragmatic Hernia Studies
- Cardiac tumors and thrombi
- Voice and Speech Disorders
Huazhong University of Science and Technology
2024-2025
Zhongnan University of Economics and Law
2025
Qiqihar Medical University
2025
Eulji University Hospital
2025
Ministry of Education of the People's Republic of China
2025
Ohio University
2019-2024
Quanzhou Normal University
2024
Biotechnology Institute
2019-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Chinese PLA General Hospital
2024
Biodegradation using enzyme-based systems is a promising approach to minimize antibiotic loads in the environment. Aminoglycosides are refractory antibiotics that generally considered non-biodegradable. Here, we provide evidence kanamycin, common aminoglycoside antibiotic, can be degraded by an environmental bacterium through deglycosylation of its 4'-amino sugar. The unprecedented inactivation kanamycin initiated novel periplasmic dehydrogenase complex, which designated AquKGD, composed...
Summary Heat‐stable antifungal factor (HSAF) produced by Lysobacter enzymogenes is a potential lead compound for developing new antibiotics. Yet, how L. regulates the HSAF biosynthesis remains largely unknown. Here, we show that 4‐hydroxybenzoic acid (4‐HBA) serves as diffusible regulating biosynthesis. The of 4‐HBA involved an oxygenase, LenB2, and mutation lenB2 almost completely abolished production, leading to significantly impaired production. Introduction heterologous gene coding...
Lysobacter species are a group of environmental bacteria that emerging as new source antibiotics. One characteristic is intrinsic resistance to multiple antibiotics, which had not been studied. To understand the mechanism, we tested effect blocking two-component regulatory systems (TCSs) on antibiotic enzymogenes, prolific producer Upon treatment with LED209, an inhibitor widespread TCS QseC/QseB, L. enzymogenes produced large amount unknown metabolite was barely detectable in untreated...
This study developed and tested a model linking independent self-construal to radical creativity by utilizing the framework of uniqueness theory. We administered time-lagged surveys 277 dyads employees their immediate supervisors. The results showed that had significant positive effect on creativity, while need for played mediating role in this relationship. Furthermore, an error-management climate positively moderated both relationship between uniqueness, indirect through uniqueness....
Renal dynamic scintigraphy is a crucial diagnostic tool for assessing renal function, yet unexpected findings can provide additional insights into extrarenal conditions. We report 2 rare cases of 99m Tc-DTPA uptake associated with adrenal tumors: one cortical carcinoma and pheochromocytoma. In both cases, significant tracer accumulation in the region was observed, highlighting an uncommon but noteworthy consideration. These emphasize importance including tumors differential diagnosis when...
Introduction: The early lung adenocarcinoma detection rate has increased with the development and application of low-dose computed tomography. However, overdiagnosis overtreatment are frequent. Here, we established a cytology grading system for adenomatous hyperplasia (AAH), in situ (AIS), minimally invasive (MIA) correlated tomography (CT) features ground-glass nodules (GGNs) to predict their biological behavior. Methods: We screened 166 GGNs pathological diagnoses AAH, AIS, MIA from 900th...
MicroRNAs (miRNAs) are pivotal regulatory molecules in gene expression, and their precise quantification is essential for elucidating roles diverse biological processes. This research paper introduces a pioneering workflow the single molecule sequencing (SMS) of miRNA, integrating advanced miRNA sample preparation with SMS sequencing. Central to our approach TUCL-Seq, which an automated, on-chip library method designed streamline process. innovative incorporates addition adaptor RNA samples...
Background This study investigates the therapeutic potential and mechanisms of Apigenin (AGN) in treating triple-negative breast cancer (TNBC). Although AGN is recognized for its anti-tumor properties, specific TNBC remain unclear. Methods To identify key genes associated with AGN’s effects on cancer, we utilized network pharmacology, conducting Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses. We developed a macrophage membrane-coated nanomicelle system...
The incidence of thyroid cancer has been rising in recent years. While tumorigenesis traditionally attributed to the accumulation genetic mutations oncogenes and tumor suppressor genes, increasing attention directed toward role epigenetic regulation development. Since 1980s, however, it acknowledged that another key regulatory system carcinogenesis: epigenetics, shedding light on gene expression without altering DNA sequence.This review synthesizes current literature alterations follicular...
Abstract Next generation sequencing ( NGS )‐based human leukocyte antigen HLA ) typing was used for ultra large‐scale genotyping of registry donors the China Marrow Donor Program CMDP ). More than 79,000 samples were subjected to at 4‐digit allelic level without ambiguities ‐A, ‐B, ‐C, DRB1 and DQB1 loci, with throughput up 2068 per lane in a HiSeq flow cell (eight lanes run), cost reduced by 95% compared that Sanger‐based typing. Two percent randomly selected quality control QC tested...
Diffuse panbronchiolitis (DPB), which is prevalent in Japan, known to be rare outside Japan. Although a case of diffuse second generation Korean was reported Japan 1986, no has been Korea. Recently we found 5 cases Korea, two histologically proven and three clinically radiologically suspected. All had the typical respiratory symptoms signs history chronic sinusitis. In suspected cases, high resolution computed tomography showed findings DPB other diseases such as pulmonary emphysema,...
The twitching motility of bacteria is closely related to environmental adaptability and pathogenic behaviors. Lysobacter a good genus in which study because the complex social activities distinct movement patterns its members. Regardless, mechanism that induces largely unknown. In this study, we found interspecies signal indole caused have irregular, random with significantly enhanced speed. Deletion qseC or qseB from two-component system for signaling perception resulted disappearance...
Four novel bioactive tetrahydroanthra-γ-pyrone compounds, shellmycin A–D (1–4), were isolated from the marine Streptomyces sp. shell-016 derived a shell sediment sample collected Binzhou Shell Dike Island and Wetland National Nature Reserve, China. The structures of these four compounds established by interpretation 1D 2D NMR HR-MS data, in which absolute configuration 1 was confirmed single crystal X-ray diffraction, compound 3 4 are pair stereoisomers. Compound 1–4 exhibited cytotoxic...
Endobronchial tuberculosis is a serious disease which frequently complicated with bronchial stenosis, and it may simulate asthma or bronchogenic carcinoma.We have analyzed the clinical characteristics of endobronchial in 166 patients, we introduce new classification tuberculosis.Endobronchial classified into seven subtypes as stenotic type fibrosis, without actively caseating type, tumorous 비cerative granular nonspecific bronchitic according to bronchoscopic findings.Actively caseaing...