A5101796483- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Esophageal and GI Pathology
- Vascular Anomalies and Treatments
- Infectious Diseases and Mycology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Epigenetics and DNA Methylation
- Sepsis Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Tumors and Oncological Cases
- Pneumocystis jirovecii pneumonia detection and treatment
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Pulmonary and Critical Care Associates
2006-2023
Georgia Institute of Technology
2021
Interface (United States)
2021
University of Michigan
2021
American Academy of Neurology
2021
Cornell University
2021
The University of Texas Southwestern Medical Center
2021
University of Washington
2010-2019
Abstract Background Treatment outcomes of patients with Mycobacterium abscessus subspecies lung disease are poor, and the microbial characteristics associated treatment have not been studied systematically. The purpose this study was to identify associations between in M. disease. Methods Sixty-seven consecutive undergoing antibiotic for ≥12 months January 2002 December 2012 were included. Morphotypic genetic analyses performed on isolates from 44 patients. Results Final sputum conversion...
The effect of the clinical phenotype Mycobacterium avium complex (MAC) lung disease on treatment outcome and redevelopment nontuberculous mycobacterial (NTM) after completion has not been studied systematically.We evaluated 481 treatment-naïve patients with MAC who underwent antibiotic for ≥12 months between January 2002 December 2013.Out patients, 278 (58%) had noncavitary nodular bronchiectatic (NB) disease, 80 (17%) cavitary NB 123 (25%) fibrocavitary disease. Favourable was higher in...
PURPOSE: To evaluate enhancement dynamics of solitary pulmonary nodules at multi–detector row computed tomography (CT) and to correlate results with extent tumor angiogenesis in pathologic specimens. MATERIALS AND METHODS: One hundred thirty-one patients underwent unenhanced thin-section CT, followed by dynamic helical CT (throughout the nodule for 30 mm along z-axis [13 images] 20-second intervals 3 minutes [130 images total]) after intravenous injection 120 mL contrast medium. Diagnosis...
We investigated the distribution of pulmonary arteriopathy in chronic hypertension (PH) a quantitative histopathologic study, using computer-assisted image analysis. also examined histologic manifestations and cellular phenotypes various obstructive intimal lesions PH with an immunohistochemical method. A total 53 lungs removed at autopsy or explantation were obtained for study from 51 documented cases moderate to severe (15 primary [PPH], eight Eisenmenger's syndrome [EISEN], 22...
To compare prospectively the diagnostic efficacies of integrated positron emission tomography (PET)/computed (CT) and 3.0-T whole-body magnetic resonance (MR) imaging for determining TNM stages in non-small cell lung cancer (NSCLC).Institutional review board approval informed consent were obtained. The study included 165 patients (125 men, 40 women; mean age, 61 years) with NSCLC proved at pathologic examination who underwent both unenhanced PET/CT MR imaging. Pathologic findings T (n = 123)...
Abstract We tested the hypothesis that CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals Parkinson's and Dementia (PD‐D) or PD Cognitive Impairment, Not (PD‐CIND). quantified Aβ 42 , total tau (T‐tau), phospho‐tau (P181‐tau) using commercially available kits. Samples were from 345 seven groups ( n ): Controls ≤50 years (35), >50 (115), amnestic Mild Impairment (aMCI) (24), AD (49), PD‐CIND (62), PD‐D (11). observed expected changes aMCI...
<h3>Background</h3> A functional repeat polymorphism in the<i>SNCA</i>promoter (<i>REP1</i>) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere the gene are associated with PD risk. <h3>Objectives</h3> To further explore association of common<i>SNCA</i>SNPs susceptibility, to determine whether allelic heterogeneity exists, and examine correlation between PD-associated variants plasma α-synuclein levels....
Multidrug-resistant (MDR) tuberculosis (TB) is more difficult to treat than drug-susceptible TB. To elucidate the optimal therapy for MDR TB, we assessed treatment outcomes and prognostic factors patients with TB.This study included who received an individualized regimen TB at Samsung Medical Center, a tertiary referral hospital in Seoul, Korea, from January 1995 through December 2004. identify related favorable outcomes, univariate comparison multiple logistic regression were performed.Of...
In Brief Objective: To evaluate the prognostic significance and predictive performance of volume-based parameters 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in early-stage non–small cell lung cancer (NSCLC). Background: Although surgical resection remains optimal treatment for NSCLC, approximately 40% patients with stage I 60% II NSCLC relapse die within 5 years after curative resection. Therefore, identification additional biomarkers is needed...
There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and incidence of lung cancer among never smokers. We aimed to estimate risk in smokers with COPD, compare it associated smoking. This cohort study involved 338 548 subjects, 40 84 years age no history at baseline, enrolled National Health Insurance Service Sample Cohort. During 2 355 005 person-years follow-up (median 7.0 years), 1834 participants developed cancer. Compared without...
Obstructive sleep apnea (OSA) affects more than 900 million adults globally and can create serious health complications when untreated; however, 80% of cases remain undiagnosed. Critically, current diagnostic techniques are fundamentally limited by low throughputs high failure rates. Here, we report a wireless, fully integrated, soft patch with skin-like mechanics optimized through analytical computational studies to capture seismocardiograms, electrocardiograms, photoplethysmograms from the...
Purpose The aim of this study was to identify tumor-specific methylation in bronchial lavage for the early detection non-small-cell lung cancer (NSCLC) by differentiating age-related from NSCLC. Patients and Methods Eighty-five NSCLC patients 127 cancer-free subjects participated study. Aberrant at promoters p16, Ras association domain family 1A (RASSF1A), fragile histidine triad (FHIT), H-cadherin, retinoic acid receptor β (RARβ) genes were evaluated resected tumor tissues samples...
Integrated (18)fluorine fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) has shown somewhat variable sensitivity and specificity for mediastinal nodal staging in granulomatous disease endemic areas. The purpose of the study was to prospectively evaluate efficacy PET/CT nonsmall cell lung cancer (NSCLC) patients a tuberculosis-endemic country.Prospective assessment diagnostic integrated detecting metastasis performed 674 (M:F ratio = 502:172; mean age,...
Purpose: To prospectively evaluate the sensitivity and specificity of integrated fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) computed (CT) (PET/CT) for preoperative diagnosis mediastinal nodal metastasis in stage T1 non–small cell lung cancer (NSCLC), with surgical histologic results as reference standards. Materials Methods: Institutional review board approval informed consent were obtained. From June 2003 to February 2005, 150 patients (89 men 61 women; mean...