A5020678369- Veterinary Oncology Research
- Microbial infections and disease research
- Eicosanoids and Hypertension Pharmacology
- Genetic and phenotypic traits in livestock
- Ear and Head Tumors
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Infectious Diseases and Mycology
- Diverse Approaches in Healthcare and Education Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Healthcare Education and Workforce Issues
- Shoulder Injury and Treatment
- Adenosine and Purinergic Signaling
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Shoulder and Clavicle Injuries
- Palliative Care and End-of-Life Issues
- Heart Rate Variability and Autonomic Control
- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
Columbia University
2020-2025
University of Cambridge
2018-2025
Bryan College
2024
Nkmax (South Korea)
2023
National Cancer Center
2009-2022
Joslin Diabetes Center
2022
Harvard University
2022
Brain (Germany)
2021
New York Proton Center
2021
Kyung-in Women's University
2000-2016
Tasmanian devils have spawned two transmissible cancer lineages, named devil facial tumor 1 (DFT1) and 2 (DFT2). We investigated the genetic diversity evolution of these clones by analyzing 78 DFT1 41 DFT2 genomes relative to a newly assembled, chromosome-level reference. Time-resolved phylogenetic trees reveal that first emerged in 1986 (1982 1989) 2011 (2009 2012). Subclone analysis documents transmission heterogeneous cell populations. has faster mutation rates than across all variant...
The purpose of this study was to develop an instrument measure nursing professional values.Forty preliminary items were selected by classifying 223 basic extracted via a literature and in-depth interviews subjects testing the relevance their contents. In order verify reliability instrument, data collected from 504 nurses in 3 general hospitals.As result item analysis, 29 total 40 items. Five factors factor variance 51.5%. For explanation variances factors, 1st factor, 'self-concept...
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The have similar patterns mutation show no evidence exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors copy number gains present on extrachromosomal double minutes. Drug screening indicates causative roles for...
Purpose The aim of this study was to identify tumor-specific methylation in bronchial lavage for the early detection non-small-cell lung cancer (NSCLC) by differentiating age-related from NSCLC. Patients and Methods Eighty-five NSCLC patients 127 cancer-free subjects participated study. Aberrant at promoters p16, Ras association domain family 1A (RASSF1A), fragile histidine triad (FHIT), H-cadherin, retinoic acid receptor β (RARβ) genes were evaluated resected tumor tissues samples...
Siamese fighting (betta) fish are among the most popular and morphologically diverse pet fish, but genetic bases of their domestication phenotypic diversification largely unknown. We assembled de novo genome a wild Betta splendens whole-genome sequenced 98 individuals across five closely related species. find evidence bidirectional hybridization between domesticated ornamental betta other discover dmrt1 as main sex determination gene in that it has lower penetrance B. . Furthermore, we genes...
Abstract BACKGROUND. Despite many reports about the involvement of DNA methyltransferases (DNMTs) in human cancers, including nonsmall cell lung cancer (NSCLC), clinicopathologic significance DNMTs primary NSCLC remains to be elucidated. METHODS. The relation between mRNA levels (1 and 3b) promoter methylation p16, RARβ2, H‐cadherin, GSTP1, RIZ, FHIT genes features 102 fresh‐frozen tissues paraffin blocks were retrospectively studied. assessed via semiquantitative reverse‐transcription...
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), species which already harbours more widespread cancer, 1 (DFT1). Here we show that contrast to DFT1, DFT2 cells express major histocompatibility complex (MHC) class I molecules, demonstrating loss of MHC not necessary for emergence cancer. However, most highly expressed alleles are common among host devils or non-polymorphic, reducing immunogenicity population...
Purpose The aim of this study was to develop a combined statistical model using both clinicopathological factors and texture parameters from 18 F-FDG PET/CT predict responses neoadjuvant chemotherapy in patients with breast cancer. Materials Methods A total 435 cancer were retrospectively enrolled. Clinical pathological data obtained electronic medical records. Texture extracted pretreatment FDG images. end point complete response, defined as the absence residual disease or presence ductal...
Abstract Emerging infectious diseases are rising globally and understanding host‐pathogen interactions during the initial stages of disease emergence is essential for assessing potential evolutionary dynamics designing novel management strategies. Tasmanian devils ( Sarcophilus harrisii ) endangered due to a transmissible cancer—devil facial tumour (DFTD)—that since its in 1990s, has affected most populations throughout Tasmania. Recent studies suggest that adapting DFTD epidemic...
Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little known its evolutionary history. We analysed genomes 648 tumours collected throughout disease range between 2003 and 2018. diverged early into five clades, three spreading widely two failing to persist. One clade replaced others at several sites, rates coinfection are high. gradually accumulates copy number variants (CNVs),...
Betta splendens , also called Siamese fighting fish or 'betta,' are a popular species in the fishkeeping hobby. Native to South- east Asia, betta have been selectively bred for their ability hundreds of years, which has resulted species' characteristic male aggression. More recently, number ornamental traits such as coloration, fin morphology, and body size. unique characteristics an evolutionary history that make them useful model studies fields behavior, endocrinology, neurobiology,...
Abstract Group-living animals must coordinate with other group members to reap the benefits and avoid costs of social living, but precisely how individuals should respond one another is mediated by interacting environmental factors. In stable groups, familiarity (i.e. prior experience particular conspecifics) often improves coordination, familiar groups outperforming unfamiliar in foraging efficiency predator evasion. Group coordination also affected individual behavioural tendencies,...
Tasmanian devils have spawned two transmissible cancer clones, known as devil facial tumour 1 (DFT1) and 2 (DFT2). DFT1 DFT2 are transmitted between animals by the transfer of allogeneic contagious cells biting, both cause tumours. tumours grossly indistinguishable, but can be differentiated using histopathology, cytogenetics or genotyping polymorphic markers. However, standard diagnostic methods require specialist skills equipment entail long processing times. Here, we describe Tasman-PCR:...
Fish oils have been shown to lower blood pressure in hypertensive subjects. All-cis-5,8,11,14,17-icosapentaenoate (EPA), one of the omega-3 polyunsaturated fatty acids, is known be major active components fish oil that has beneficial effects on cardiovascular system. However, little about antihypertensive effect EPA alone pressure. In present study, we determined spontaneous and noradrenaline-evoked release ATP, ADP, AMP, adenosine from caudal arteries aged (100 weeks old) Wistar rats which...
Objective: Increasing the mass and/or activity of brown adipose tissue (BAT) is one promising avenue for treating obesity and related metabolic conditions, given that BAT has a high potential energy expenditure capable improving glucose lipid homeostasis. occurs either in discrete "classical" depots, or interspersed white (WAT), termed "inducible/recruitable" BAT, 'beige/brite' adipocytes. We others have demonstrated bone morphogenetic protein 7 (BMP7) induces adipogenesis committed...
Betta splendens, also known as Siamese fighting fish or “betta,” is a freshwater species renowned for its astonishing morphological diversity and extreme aggressive behavior. Despite recent advances in our understanding of the genetics neurobiology betta, lack tools to manipulate their genome has hindered progress at functional mechanistic levels. In this study, we outline use three genetic manipulation technologies, which have optimized betta: CRISPR/Cas9-mediated knockout, knockin,...
To determine whether the antihypertensive effects of exercise are associated with release ATP and its metabolites from arteries, we assayed blood pressure adenine nucleotides nucleosides caudal arteries exercised sedentary aged hypercholesterolemic rats. Exercise on a treadmill for 12 wk significantly decreased rise in systolic diastolic by 7.5 15.9%, respectively, advanced age. The concentrations oleic, linoleic, linolenic acids artery exercise, demonstrating an association between...