A5100720913- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Breast Cancer Treatment Studies
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
- Alzheimer's disease research and treatments
- Proteoglycans and glycosaminoglycans research
- Enzyme Structure and Function
- Breast Lesions and Carcinomas
- Bone Metabolism and Diseases
- Fibroblast Growth Factor Research
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Microbial Metabolic Engineering and Bioproduction
- Lanthanide and Transition Metal Complexes
- Biochemical and Structural Characterization
Korea Advanced Institute of Science and Technology
2000-2024
National Cancer Center
2021-2024
Korea Atomic Energy Research Institute
2012-2024
Samsung Medical Center
2024
National Cancer Center
2022
Korea Yakult (South Korea)
2016
Yonsei University
2015
Korea Institute of Science and Technology
2011-2013
Hormel (United States)
2012
University of Minnesota
2012
We develop a biocompatible and<italic>in situ</italic>HA hydrogel<italic>via</italic>a bioorthogonal click reaction for cartilage tissue engineering.
We compared the transcriptome, proteome, and nucleotide sequences between parent strain Escherichia coli W3110 L-threonine-overproducing mutant E. TF5015. DNA macroarrays were used to measure mRNA levels for all of genes coli, two-dimensional gel electrophoresis was compare protein levels. It observed that only 54 4,290 (1.3%) exhibited differential expression profiles. Typically, such as aceA, aceB, icdA, gltA, glnA, leu operon, proA, thrA, thrC, yigJ, which are involved in glyoxylate...
An efficient and straightforward method for radiolabeling nanoparticles is urgently needed to understand the in vivo biodistribution of nanoparticles. Herein, we investigated a facile highly strategy prepare radiolabeled glycol chitosan with 64Cu via strain-promoted azide–alkyne cycloaddition strategy, which often referred as click chemistry. First, azide (N3) group, allows preparation by copper-free chemistry, was incorporated (CNPs). Second, strained cyclooctyne derivative, dibenzyl (DBCO)...
A bio-inspired approach for detoxification of water has been investigated. In this approach, three major classes toxic agents, heavy-metal ions (Cr, Hg, Pb, Cu, and Cd), organic species (4-aminopyridine), a radioisotope (Lutetium-177) were effectively removed from contaminated by polydopamine, mussel-inspired adhesive catecholamine (see figure). addition, polydopamine filter was easily regenerated treatment with acid or hydrogen peroxide. Detailed facts importance to specialist readers are...
Imaging techniques including computed tomography, magnetic resonance imaging, and positron emission tomography (PET) offer many potential benefits to diagnosis treatment of cancers. Each method has its own strong weak points. Therefore, multimodal imaging have been highlighted as an alternative for overcoming the limitations each respective method. In this study, we fabricated PET/optical activatable probe based on glycol chitosan nanoparticles (CNPs) imaging. To prepare dual probes CNPs,...
Abstract Recent evidence suggests that tau aggregates are not only neurotoxic, but also propagate in neurons acting as a seed for native aggregation. Prion-like transmission is now considered an important pathogenic mechanism driving the progression of pathology brain. However, prion-like species have been clearly characterized. To identify infectious conformers, here we prepared diverse and evaluated effect on inducing intracellular tau-aggregation. Among tested, dimer containing...
Cell labeling and tracking are important processes in understanding biologic mechanisms the therapeutic effect of inoculated cells vivo.Numerous attempts have been made to label track vivo; however, these methods limitations as a result their biological effects, including secondary phagocytosis macrophages genetic modification.Here, we investigated new cell strategy based on metabolic glycoengineering bioorthogonal click chemistry.We first treated with tetra-acetylated...
Purpose The aim of this study was to develop a combined statistical model using both clinicopathological factors and texture parameters from 18 F-FDG PET/CT predict responses neoadjuvant chemotherapy in patients with breast cancer. Materials Methods A total 435 cancer were retrospectively enrolled. Clinical pathological data obtained electronic medical records. Texture extracted pretreatment FDG images. end point complete response, defined as the absence residual disease or presence ductal...
To evaluate the pharmacokinetics of compound K after oral administration HYFRG and RG in humans, an open‐label, randomized, single‐dose, fasting, one‐period pharmacokinetic study was conducted. After a single 3 g dose to 24 healthy Korean males, mean (±SD) AUC 0– t C max from were 1466.83 ± 295.89 ng·h/mL 254.45 51.20 ng/mL, being 115.2‐ 80‐fold higher than those for (12.73 7.83 3.18 1.70 ng/mL), respectively; case Sprague Dawley rats 58.03 32.53 15.19 10.69 6.3‐ 6.0‐fold (9.21 7.52 2.55...
Metabolic labeling techniques are powerful tools for cell labeling, tracking and proteomic analysis.However, at present, the effects of metabolic agents on metabolism physiology not known.To address this question, in study, we analyzed cells treated with Ac4ManNAz through microarray analysis analyses membrane channel activity, individual bio-physiological properties, glycolytic flux.According to results, treatment 50 μM led reduction major cellular functions, including energy generation...
The amphiphilic hyaluronic acid–5β-cholanic acid (HA–CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated nanoparticles (HNPs) for a tumor-targeted optical magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs preferentially accumulated in the tumor region, implying that hydrophilic HA shells of allow prolonged circulation excellent active targeting SPION encapsulated tumor-bearing mice.
Cancer cells can secrete exosomes under various stressful conditions, whose functions are involved in the delivery of biologically active materials into host and/or modulation immune responses. Therefore, an improved understanding immunological interventions that stress-induced tumor have may provide novel therapeutic approaches and more effective vaccine designs. Here, we confirmed phenotypical functional alterations dendritic (DCs), which act as a bridge between innate adaptive arms...
Metabolic labeling is one of the most powerful methods to label live cell for in vitro and vivo tracking. However, cellular mechanisms by modified glycosylation due metabolic agents are not fully understood. Therefore, has yet been widely used EPC tracking labeling. In this study, functional properties such as proliferation, migration permeability gene expression patterns agent-treated hUCB-EPCs were analyzed demonstrate effects agents. As results, 10 μM Ac4ManNAz treatment had no on...