A5073866582- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- Protease and Inhibitor Mechanisms
- Virus-based gene therapy research
- Click Chemistry and Applications
- Graphene and Nanomaterials Applications
- Photoacoustic and Ultrasonic Imaging
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Surfactants and Colloidal Systems
- Photodynamic Therapy Research Studies
- biodegradable polymer synthesis and properties
- Proteoglycans and glycosaminoglycans research
- Ultrasound and Hyperthermia Applications
- Polymer Surface Interaction Studies
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Lipid Membrane Structure and Behavior
Korea Institute of Science and Technology
2016-2025
Korea University
2016-2025
Yonsei University
2006-2025
Gangnam Severance Hospital
2025
Dana-Farber Cancer Institute
2019-2024
Harvard University
2011-2024
PRG S&Tech (South Korea)
2005-2017
Seoul National University
1998-2017
Asan Medical Center
2009-2017
Center for Systems Biology
2011-2017
Macrophages (Mϕs) critically contribute to wound healing by coordinating inflammatory, proliferative, and angiogenic processes. A proper switch from proinflammatory M1 anti-inflammatory M2 dominant Mϕs accelerates the processes leading favorable wound-care outcomes. Herein, an exosome-guided cell reprogramming technique is proposed directly convert for effective management. The Mϕ-derived exosomes (M2-Exo) induce a complete conversion of in vitro. reprogrammed turn Arginase (M2-marker) iNOS...
Abstract Advances in nanotechnology have contributed to the development of novel nanoparticles that enable tumor‐specific delivery imaging probes and therapeutic agents cancer therapy. Nanobiotechnology combines with molecular imaging, which has led generation new multifunctional for Multifunctional hold great promise future treatment because they can detect early onset each individual patient deliver suitable enhance efficacy. The combination tumor‐targeted therapy an all‐in‐one system...
Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors for effective cancer therapy. In this study, poly(ethylene glycol) (PEG)-conjugated hyaluronic acid (P-HA-NPs) were investigated as carriers anticancer drugs including doxorubicin camptothecin (CPT). P-HA-NPs internalized into cells (SCC7 MDA-MB-231) via receptor-mediated endocytosis, but rarely taken up by normal fibroblasts (NIH-3T3). During in vitro tests, rapidly released when incubated with...
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of sonosensitizer such TiO2 nanoparticles (NPs) is still major concern. Here, we have developed hydrophilized Au-TiO2 nanocomposites (HAu-TiO2 NCs) sonosensitizers for improved SDT. The physicochemical properties HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure ultrasound, large quantity reactive...
Nanodiagnosis: A matrix-metalloproteinase (MMP) sensitive gold-nanoparticle (AuNP) imaging probe quenches conjugated near-infrared (NIR) dyes with high efficiency and is specifically activated by the target MMPs (see picture, left). With this system, nanomolar amounts of protease can be detected—both in vitro vivo. Experiments disclose an apparent positive contrast MMPs-positive tumor-bearing mice (right). Supporting information for article available on WWW under...
Abstract The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO 2 NP) that can be activated by ultrasound generate reactive oxygen species (ROS). When administered systemically mice, HTiO NPs effectively suppressed growth tumours after treatments. In tumour tissue, levels proinflammatory cytokines were...
Right on target: An in vivo tumor-targeting strategy using nanoparticles has been developed. unnatural sialic acid (green, see scheme) with azide groups is artificially generated the target site by metabolic glycoengineering. These then effectively enhance accumulation of tumor an bioorthogonal copper-free click reaction.