A5002406045- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Photodynamic Therapy Research Studies
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Drug Delivery Systems
- Characterization and Applications of Magnetic Nanoparticles
- Barrier Structure and Function Studies
- Phytoestrogen effects and research
- Polymer Surface Interaction Studies
- Nanocluster Synthesis and Applications
- Liver physiology and pathology
- Galectins and Cancer Biology
- Virus-based gene therapy research
- Nanopore and Nanochannel Transport Studies
- Psoriasis: Treatment and Pathogenesis
Gangneung–Wonju National University
2023-2024
Korea Institute of Science and Technology
2019-2024
Sungkyunkwan University
2013-2022
Korea University of Science and Technology
2021
Bio-Medical Science (South Korea)
2021
Suwon Research Institute
2015-2018
Government of the Republic of Korea
2015-2018
Zero to Three
2015
Kyung Hee University
2011-2012
Washington State University
2008
Summary Total phenolic content (PC) was ∼12 mg g −1 in lentils, 2.2 chickpeas, 2.3 soybeans, 2.5 yellow peas and 1.2 green peas. antioxidant activity (AA) determined by ABTS (2,2′‐azinobis‐3‐ethyl‐benzthiazoline‐6‐sulfonic acid) assay highest lentils at around 14 μmol Trolox equivalent capacity (TEAC) lowest 1.9 TEAC . Bound phytochemicals contributed to 82–85% total AA lentils. Free more peas, soybeans than bound phytochemicals. PC reduced ∼80% <30% decortication, 16–41% chickpeas...
The major issues of self-assembled nanoparticles as drug carriers for cancer therapy include biostability and tumor-targetability because the premature release from nonspecific accumulation drug-loaded may cause undesirable toxicity to normal organs lower therapeutic efficacy. In this study, we developed robust tumor-targeted nanocarriers based on an amphiphilic hyaluronic acid (HA)-polycaprolactone (PCL) block copolymer, in which HA shell was cross-linked via a bioreducible disulfide...
Bioreducible carboxymethyl dextran (CMD) derivatives are synthesized by the chemical modification of CMD with lithocholic acid (LCA) through a disulfide linkage. The hydrophobic nature LCA allows conjugates (CMD‐SS‐LCAs) to form self‐assembled nanoparticles in aqueous conditions. Depending on degree substitution, particle diameters range from 163 242 nm. Doxorubicin (DOX), chosen as model anticancer drug, is effectively encapsulated into high loading efficiency (>70%). In vitro optical...
Optically active nanomaterials have shown great promise as a nanomedicine platform for photothermal or photodynamic cancer therapies. Herein, we report gold-nanoclustered hyaluronan nanoassembly (GNc-HyNA) photothermally boosted tumor ablation. Unlike other supramolecular gold constructs based on nanoparticle building blocks, this system utilizes the of amphiphilic conjugates drug carrier hydrophobic therapy agent verteporfin, polymeric reducing agent, and an organic nanoscaffold upon which...
Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and responsible for multiple physiological pathological functions. In the last decade, PDVs have gained much attention their involvement in different biological processes, including intercellular communication defense response, recent scientific evidence has opened a new avenue applications cancer treatment. Nevertheless, remains unknown about these vesicles, current research inconsistent. This review...
RNA nanotechnology, including rolling circle transcription (RCT), has gained increasing interest as a fascinating siRNA delivery nanoplatform for biostable and tumor-targetable RNA-based therapies. However, due to the lack of fine-tuning technologies nanostructures, relationship between physicochemical properties efficacy polymeric nanoparticles (PRNs) with different sizes not yet been fully elucidated. Herein, we scrutinized effects size/surface chemistry-tuned PRNs on biological...
Inflammatory bowel disease (IBD) is a chronic disorder characterized by recurrent gastrointestinal inflammation, lacking precise aetiology and definitive cure. The gut microbiome vital in preventing treating IBD due to its various physiological functions. In the interplay between human health, extracellular vesicles secreted bacteria (BEVs) are key mediators. Herein, we explore role of Roseburia intestinalis (R)-derived EVs (R-EVs) as potent anti-inflammatory mediators dextran sulfate...
Introduction: Hyaluronic acid (HA) has emerged as a promising applicant for the tumor-targeted delivery of various therapeutic agents. Because its biocompatibility, biodegradability and receptor-binding properties, HA been extensively investigated drug carrier. In this review, recent advances in HA-based nanomedicines are discussed.
Abstract Extracellular vesicles (EVs) are essential mediators in intercellular communication that have emerged as natural therapeutic nanomedicines for the treatment of intractable diseases. Their applications, however, been limited by unpredictable vivo biodistribution after systemic administration. To control fate EVs, their surfaces should be properly edited, depending on target site action. Herein, based bioorthogonal copper‐free click chemistry (BCC), surface‐edited EVs were prepared...
Although conventional topical approaches for treating psoriasis have been offered as an alternative, there are still unmet medical needs such low skin-penetrating efficacy and off-target adverse effects. A hyaluronic acid nanoparticle (HA-NP) formed by self-assembly of HA-hydrophobic moiety conjugates has broadly studied a nanocarrier long-term target-specific delivery drugs, owing to their excellent physicochemical biological characteristics. Here, we identify HA-NPs therapeutics using in...
Hyaluronic acid nanoparticles (HA-NPs), mineralized by calcium phosphate, were synthesized as a robust carrier of the anticancer drug, doxorubicin (DOX). The HA-NPs readily in presence nitrate and ammonium which was confirmed various instruments such FT-IR, thermogravimetric analysis, transmission electron microscopy, energy-dispersive X-ray photoelectron spectroscopy. Mineralization reduced particle size PBS (pH 7.4) from 263 nm to 142 nm, indicating formation compact nanoparticles....