A5074548240- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Probiotics and Fermented Foods
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Inflammatory Bowel Disease
- Bone Metabolism and Diseases
- Connective tissue disorders research
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Proteoglycans and glycosaminoglycans research
- IL-33, ST2, and ILC Pathways
- Protein Degradation and Inhibitors
- Advanced Nanomaterials in Catalysis
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Dermatology and Skin Diseases
- Cancer-related gene regulation
Sungkyunkwan University
2018-2025
Shanghai University
2024-2025
Bio Pharm Dongsung (South Korea)
2024
Zhongshan Hospital
2024
Ajou University
2016-2023
Lotte Fine Chemical (South Korea)
2018-2022
Yonsei University
2012-2021
First Affiliated Hospital of Jiamusi University
2020
Jiamusi University
2020
Moscow Research and Clinical Center for Neuropsychiatry
2017
Early T cells keep autoimmunity at bay A major challenge faced by the immune system is to react foreign substances, such as microbes, while simultaneously tolerating self. Upsetting this balance leads autoimmunity. Regulatory (T regs ), are a subset of that help maintain balance. Yang et al. found murine reg generated very early in life distinct from those older animals and play an especially important role keeping check (see Perspective Tanaka Sakaguchi). These changes due differences way...
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that the most common joint worldwide. Mesenchymal stem cells (MSCs) have been extensively explored for treatment OA. Recently, it has demonstrated MSC-derived extracellular vesicles (EVs) may contribute to potential mechanisms MSC-based therapies. In this study, we investigated therapeutic human adipose-derived EVs (hASC-EVs) in alleviating OA, along with mechanism. were isolated from culture supernatants hASCs by...
Hypoxia-inducible factor 2α (HIF-2α) (encoded by Epas1) causes osteoarthritic (OA) cartilage destruction regulating the expression of catabolic genes. We undertook this study to explore role interleukin-6 (IL-6) in HIF-2α-mediated OA mice.The HIF-2α, IL-6, and factors was determined at messenger RNA protein levels primary culture mouse chondrocytes, human cartilage, experimental cartilage. Experimental wild-type, HIF-2α-knockdown (Epas1+/-), Il6-/- mice caused intraarticular injection Epas1...
<h3>Objective</h3> Hypoxia-inducible factor 2α (HIF-2α), encoded by <i>Epas1</i>, causes osteoarthritic cartilage destruction regulating the expression of matrix-degrading enzymes. We undertook this study to explore role nicotinamide phosphoribosyltransferase (NAMPT or visfatin) in HIF-2α-mediated destruction. <h3>Methods</h3> The HIF-2α, NAMPT and enzymes was determined at mRNA protein levels human osteoarthritis (OA) cartilage, mouse experimental OA primary cultured chondrocytes....
Osteoarthritis (OA) is a degenerative joint disorder associated with inflammation, functional disability, and high socioeconomic costs. The development of effective therapies against inflammatory OA has been limited owing to its complex multifactorial nature. efficacy Prussian blue nanozymes coated Pluronic (PPBzymes), US Food Drug Administration-approved components, their mechanisms action have described in this study, PPBzymes characterized as new therapeutic. Spherical were developed via...
Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal role and dysregulation various pathological processes, we investigated the of RIP3 axis OA pathogenesis.Experimental was induced wild-type or Rip3 knockout mice by surgery to destabilise medial meniscus (DMM) intra-articular injection adenovirus...
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
Stress granules are membraneless organelles composed of numerous components including ribonucleoproteins. The stress characterized by a dynamic complex assembly in response to various environmental stressors, which has been implicated the coordinated regulation diverse biological pathways, exert protective role against stress-induced cell death. Here, we show that granule formation is induced morusin, novel phytochemical displaying antitumor capacity through barely known mechanisms....
Background and Purpose 3′‐Sialyllactose (3′‐SL) is a safe compound that present in high levels human milk. Although it has anti‐inflammatory properties supports immune homeostasis, its effect on collagen‐induced arthritis (CIA) unknown. In this study, we investigated the prophylactic therapeutic of 3′‐SL progression rheumatoid (RA) vitro vivo models. Experimental Approach The anti‐arthritic was analysed with fibroblast‐like synoviocytes an mouse model CIA. RT‐PCR, Western blotting ELISA were...
Abstract Although Hif‐2α is a master regulator of catabolic factor expression in osteoarthritis development, inhibitors remain undeveloped. The aim this study was to determine whether Cirsium japonicum var. maackii (CJM) extract and one its constituents, apigenin, could attenuate the Hif‐2α‐induced cartilage destruction implicated progression. In vitro vivo studies demonstrated that CJM reduced IL‐1β‐, IL‐6, IL‐17‐ TNF‐α‐induced up‐regulation MMP3, MMP13, ADAMTS4, ADAMTS5 COX‐2 blocked...
3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation maintain tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate responses in atopic dermatitis (AD) pathogenesis. Oral administration reduced AD-like symptoms such as ear, epidermal, dermal thickness repeated topical application house dust mites (HDM)...
Although activin receptor IIB (ACVR2B) is emerging as a novel pathogenic receptor, its ligand and assembled components (or assembly) are totally unknown in the context of osteoarthritis (OA) pathogenesis. The present results suggest that upregulation ACVR2B assembly could affect osteoarthritic cartilage destruction. It shown ligand, A, regulates catabolic factor expression through OA development. Activin A Tg mice (Col2a1-Inhba) exhibit enhanced destruction, whereas heterozygous KO (Inhba+/-...
Abstract 3′‐Sialyllactose has specific physiological functions in a variety of tissues; however, its effects on osteoarthritic development remain unknown. Here, we demonstrated the function 3′‐sialyllactose cartilage destruction. In vitro and ex vivo , biochemical histological analysis that was sufficient to restore synthesis Col2a1 accumulation sulphated proteoglycan, critical factor for regeneration development, blocked expression Mmp3, Mmp13 Cox2 induced by IL ‐1β, ‐6, ‐17 TNF ‐α, which...