A5008036043- Genetic and Kidney Cyst Diseases
- Wastewater Treatment and Nitrogen Removal
- Asthma and respiratory diseases
- Protist diversity and phylogeny
- Water Quality Monitoring and Analysis
- Microtubule and mitosis dynamics
- Respiratory and Cough-Related Research
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Renal and related cancers
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Constructed Wetlands for Wastewater Treatment
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Osteoarthritis Treatment and Mechanisms
- Hedgehog Signaling Pathway Studies
- Genomics and Chromatin Dynamics
- Microbial Community Ecology and Physiology
- Biomedical Research and Pathophysiology
- Genetic Associations and Epidemiology
- Connexins and lens biology
- Proteoglycans and glycosaminoglycans research
- Antimicrobial Peptides and Activities
Ulsan National Institute of Science and Technology
2016-2025
Institute for Basic Science
2017-2025
Hanyang University
2023-2024
Cheju Halla General Hospital
2020-2023
Korea National Institute of Health
2013-2022
Center for Genomic Science
2020
Kyung Hee University
2019
Cheongju University
2018
Pusan National University
2000-2017
The University of Texas at Austin
2005-2016
The planar cell polarity (PCP) signaling pathway governs collective movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. septins cytoskeletal controlling behaviors such as division migration. Here, we identified control septin localization by protein Fritz a crucial point for both movement ciliogenesis Xenopus embryos. We linked mutations human to Bardet-Biedl Meckel-Gruber syndromes, notable link given that other genes mutated...
Biologists have long used model organisms to study human diseases, particularly when the bears a close resemblance disease. We present method that quantitatively and systematically identifies nonobvious equivalences between mutant phenotypes in different species, based on overlapping sets of orthologous genes from human, mouse, yeast, worm, plant (212,542 gene-phenotype associations). These phenotypes, or phenologs, predict unique associated with diseases. Our suggests yeast for angiogenesis...
Abstract We introduce the design and implementation of a new array, Korea Biobank Array (referred to as KoreanChip), optimized for Korean population demonstrate findings from GWAS blood biochemical traits. KoreanChip comprised >833,000 markers including >247,000 rare-frequency or functional variants estimated >2,500 sequencing data in Koreans. Of 833 K markers, 208 were directly genotyped. Particularly, >89 presented East Asians. achieved higher imputation performance owing...
Abstract Herein, we developed a high‐performance lithium ion conducting hybrid solid electrolyte, consisted of LiTFSI salt, Py 14 TFSI ionic liquid, and TiO 2 nanoparticles. The electrolyte prepared by facile method had high room temperature conductivity, excellent thermal stability low interface resistance with good contact. In addition, the transference number was highly increased scavenger effect With pouch‐type solid‐state battery exhibited initial discharge capacity 150 mA h g −1 at...
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology cytosolic HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, seems to play critical roles in metabolic processes energy production, such glycolysis and β-oxidation. also reported direct target of PTEN-induced kinase 1 (PINK1) may be cause Parkinson's disease (PD) humans. Although the biochemical are under...
Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility all these nanobiomaterials is still largely unexamined. Here, we report preparation blood-compatible carbon nanotubes (CNTs) that potentially represent building blocks nanodevices having applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove heparinization can significantly enhance nanomaterials.
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
An ideal cancer therapeutic strategy involves the selective killing of cells without affecting surrounding normal cells. However, researchers have failed to develop such methods for achieving cell death because shared features between cancerous and In this study, we developed a called cancer-specific insertions-deletions (InDels) attacker (CINDELA) selectively induce using CRISPR-Cas system. CINDELA utilizes previously unexplored idea introducing CRISPR-mediated DNA double-strand breaks...
The specialized cell types of the mucociliary epithelium (MCE) lining respiratory tract enable continuous airway clearing, with its defects leading to chronic diseases. molecular mechanisms driving fate acquisition and temporal specialization during epithelial development remain largely unknown. Here, we profile developing Xenopus MCE from pluripotent mature stages by single-cell transcriptomics, identifying multipotent early progenitors that execute multilineage cues before specializing...
Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, ER-associated degradation (ERAD) complex-which removes misfolded unfolded proteins to maintain proteostasis ER- plays an indispensable role building maintaining cartilage. Here, we examined necessity of ERAD complex chondrocytes for cartilage formation maintenance. We show gene expression is exponentially increased during chondrogenesis,...
INTRODUCTIONImmunocytochemistry (ICC) is widely exploited in studying mammalian systems, but underutilized among Xenopus developmental biologists. This stems, part, from the relatively small number of antibodies available for use research. Common misconceptions about ICC embryos also prevail, discouraging researchers trying procedure. However, with simple and effective. article describes methods whole-mount embryos. Also included are procedures to quench autofluorescence remove surface...
Planar cell polarity signaling controls a variety of polarized behaviors. In multiciliated Xenopus epidermal cells, recruitment Dishevelled (Dvl) to the basal body and its localization center ciliary rootlet are required correctly position motile cilia. We now report that anaphase-promoting complex (APC/C) recognizes D-box motif Dvl ubiquitylates on highly conserved lysine residue. Inhibition APC/C function by knockdown ANAPC2 subunit disrupts cilia alters directionality fluid movement along...
INTRODUCTION Embryos of the frog Xenopus laevis are an ideal model system for in vivo imaging dynamic biological processes, from inner workings individual cells to reshaping tissues during embryogenesis. Their externally developing embryos more amenable analysis than internally mammalian embryos, and large size make them particularly suitable time-lapse tissue-level morphogenetic events. In addition, larger those other vertebrate models, making cell behavior subcellular processes (e.g.,...