A5088825652- Agriculture, Soil, Plant Science
- Food Quality and Safety Studies
- Renal and related cancers
- Ecology and Conservation Studies
- Silk-based biomaterials and applications
- Adipose Tissue and Metabolism
- Soil Carbon and Nitrogen Dynamics
- Engineering Applied Research
- Vehicle emissions and performance
- Diverse Topics in Contemporary Research
- Air Quality and Health Impacts
- Consumer Perception and Purchasing Behavior
- Phytochemicals and Antioxidant Activities
- DNA Repair Mechanisms
- Vehicle Noise and Vibration Control
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Hydrolysis and Bioactive Peptides
- Horticultural and Viticultural Research
- Aerodynamics and Fluid Dynamics Research
- RNA modifications and cancer
- RNA Research and Splicing
- Environmental Policies and Emissions
- Phytochemistry and Biological Activities
Korea Institute of Oriental Medicine
2020-2025
Ajou University
2025
Ajou University Hospital
2025
Jeonbuk National University
2025
Korea University of Science and Technology
2023-2024
Korea Research Institute of Bioscience and Biotechnology
2024
Korea Institute of Toxicology
2024
Kafkas University
2024
Hallym University
2006-2024
Korea University
2024
Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue high-sucrose diet-fed Sprague-Dawley (SD) rats reduced glucose levels type 2 diabetes mice. In the current study, conducted further experiments to extend these observations elucidate mechanism involved. C57BL/6J mice received normal diet, diet or containing L. (10(9) 10(10) CFU) for 10 weeks. The administration of...
The concept of digital twin, a kind virtual things with the precise states corresponding physical systems, is suggested by industrial domains to accurately estimate status and predict operation machines. Digital twin can be used for development critical such as self-driving cars autoproduction factories. There, however, will so different twins in terms resolution, complexity, modelling languages formats. It required cooperate heterogeneous standardized ways. Since centralized system uses too...
Electronic packaging materials with high thermal conductivity and suitable viscosity are necessary in the manufacturing of highly integrated electronic devices for efficient heat dissipation during operation. This study looked at effect boron nitride (BN) platelets on rheology composites based alumina (Al₂O₃) epoxy resin (EP) potential application as packaging. The composite were increased upon increasing filler content. Furthermore, BN/Al₂O₃/EP was much higher than that Al₂O₃/EP almost same...
An ideal cancer therapeutic strategy involves the selective killing of cells without affecting surrounding normal cells. However, researchers have failed to develop such methods for achieving cell death because shared features between cancerous and In this study, we developed a called cancer-specific insertions-deletions (InDels) attacker (CINDELA) selectively induce using CRISPR-Cas system. CINDELA utilizes previously unexplored idea introducing CRISPR-mediated DNA double-strand breaks...
The siRNA silencing approach has long been used as a method to regulate the expression of specific target genes in vitro and vivo. However, effectiveness delivery nonspecific immune-stimulatory function are limiting factors for therapeutic applications siRNAs. To overcome these limitations, we developed self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticles made individually biconjugated siRNAs with hydrophilic polymer lipid on their ends characterized stability, function, vivo...
Maintaining stability of replication forks is important for genomic integrity. However, it not clear how replisome proteins contribute to fork under stress. Here, we report that ATAD5, a PCNA unloader, plays multiple functions at stalled including promoting its restart. ATAD5 depletion increases instability upon hydroxyurea treatment in cultured cells and mice. recruits RAD51 an ATR kinase-dependent manner by hydroxyurea-enhanced protein-protein interactions timely removes from recruitment....
Components of silk including fibroin have long been used as anti-diabetic remedies in oriental medicine.However, detailed mechanisms underlying these antidiabetic effects remain unclear.In this study, we examined the activity hydrolysate (SFH) C57BL/KsJ-db/db (db/db) mice, a well-known animal model non-insulin dependent diabetes mellitus.When db/db mice were administered SFH drinking water for 6 weeks, hyperglycemia animals gradually disappeared and level glycosylated hemoglobin decreased,...
Abstract The oncogenic fusion gene EWS–WT1 is the defining chromosomal translocation in desmoplastic small round-cell tumors (DSRCT), a rare but aggressive soft tissue sarcoma with high rate of mortality. functions as an aberrant transcription factor that drives tumorigenesis, mechanistic basis for its pathogenic activity not well understood. To address this question, we created transgenic mouse strain permits physiologic expression under native murine Ews promoter. led to dramatic induction...
Sepsis causes multiple organs failures and eventually death. Changes in blood constituents due to sepsis lead alterations hemorheological properties, cell adhesiveness. In this study, a new microfluidic system is proposed measure temporal variations biophysical properties of after injecting lipopolysaccharide (LPS) into rat extracorporeal model under ex vivo condition. To viscosity, the interfacial line between reference fluid formed Y-shaped channel. Based on relation width pressure ratio,...
Significance Ewing sarcoma protein (EWS) is essential for various cellular processes but its role in energy metabolism has not been demonstrated. This study identifies a new of EWS mitochondria and homeostasis. Loss leads to increased degradation PGC-1α, critical maintaining mitochondrial function metabolism. The due an expression FBXW7, that promotes PGC-1α degradation. In mice lacking EWS, significant decreases levels number are observed brown fat, skeletal muscles, liver. A novel...
Abstract Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) alleviated fibrosis by stably silencing AREG gene, and reduced side effects of conventional siRNA treatment pulmonary However, therapeutic effect SAMiRNA-AREG renal has not been studied until now. We used two animal models generated unilateral ureteral obstruction (UUO) an adenine diet (AD) to...
<title>Abstract</title> This study compared the sex-specific influence of maternal and paternal metabolic syndrome on offspring using 2007–2020 Korean National Health Nutritional Examination Survey database. As a result, male fathers with presented increased blood glucose levels unfavorable lipid profiles, whereas female pressure, triglyceride levels, decreased HDL cholesterol levels. Maternal was associated adverse profiles in both sexes, along pressure males waist circumference systolic...
Particulate matter (PM) is a harmful air pollutant associated with respiratory and cardiovascular diseases, but its effects on adaptive immunity are poorly understood. This study investigates the role of NRF2 in T cells mediating immune pulmonary responses to long-term PM exposure, highlighting impact inhalation toxicity. To establish mouse model lung injury induced by C57BL/6 mice were intranasally administered 20 μg/kg PM10 or PM2.5 daily for 16 weeks. Lung parameters analyzed...