A5100414531- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Soft tissue tumor case studies
- Intensive Care Unit Cognitive Disorders
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Renal and related cancers
- Multiple Myeloma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Respiratory Support and Mechanisms
- Chromatin Remodeling and Cancer
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Biomedical Research and Pathophysiology
- Neuroscience and Neuropharmacology Research
Soonchunhyang University
2015-2024
Seoul National University Bundang Hospital
2022
Hankyong National University
2018
Soonchunhyang University Hospital
2018
University of California, Los Angeles
2017
Sanofi (South Korea)
2016
Massachusetts Institute of Technology
2013-2015
Pusan National University Dental Hospital
2015
Samsung Medical Center
2013
Sungkyunkwan University
2013
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen evaluated as potential inhibitor mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID613034 inhibited kinase at submicromolar concentrations cellular assays phosphorylation substrates, including AKT (Ser-473), NDRG1 (Thr-346) PKCα (Ser-657), while having no appreciable effects on status mTORC1 substrate S6K (Thr-389) or mTORC1-dependent...
Synaptic vesicle fusion mediates communication between neurons and is triggered by rapid influx of Ca 2+ . The -triggering step for regulated the synaptic transmembrane protein Synaptotagmin 1 (Syt1). Syt1 contains two cytoplasmic C2 domains, termed C2A C2B, which coordinate binding. Although C2B share similar topology, binding ions to domain has been suggested as only critical trigger evoked release. If how function coordinated with remain unclear. In this study, we generated a panel...
In patients with type 2 diabetes mellitus (T2DM), diabetic kidney disease (DKD) is diagnosed based on clinical features. A biopsy used only in selected cases. This study aimed to reconsider the role of a predicting renal outcomes. Clinical and laboratory parameters results were obtained from 237 T2DM who underwent biopsies at Soonchunhyang University Cheonan Hospital between January 2000 March 2020 analyzed. Of patients, 29.1% had DKD only, 61.6% non-DKD (NDKD), 9.3% coexisting NDKD...
The enhancer of zeste homologue 2 (EZH2) is a catalytic subunit the polycomb repressive complex 2, highly conserved histone methyltransferase. EZH2 overexpression has been implicated in various malignancies, including breast cancer, where associated with poor outcomes. This study aims to clarify nuclear expression levels cancers using immunohistochemistry (IHC) and correlate these findings clinicopathologic variables, prognostic significance. IHC was performed on tissue microarrays 432...
Significance Synaptotagmin 1 (Syt1) is widely considered to act as the fast Ca 2+ sensor for synchronous synaptic vesicle fusion through its tandem -binding C2 domains. Here we demonstrate that Syt1’s domains activate rapid only if they are in proper orientation and specifically tethered with an appropriate linker distance. Although expression of cytoplasmic Syt1 alone did not support release, it enhance asynchronous component exocytosis. These findings tethering positions protein allow...
Abstract Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) alleviated fibrosis by stably silencing AREG gene, and reduced side effects of conventional siRNA treatment pulmonary However, therapeutic effect SAMiRNA-AREG renal has not been studied until now. We used two animal models generated unilateral ureteral obstruction (UUO) an adenine diet (AD) to...
Klotho deficiency is relevant to renal fibrosis and podocyte injury in vivo vitro. We examined whether histological findings of biopsy specimens were associated with the levels soluble klotho humans. investigated 67 patients detailed microscopic reviewed. Soluble serum/urinary urinary angiotensinogen assessed by enzyme-linked immunosorbent assays, tissue expression was immunohistochemical staining. The median age study participants 35.6 years. High serum (≥14 pg/mL) decreased odds ratios...
The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered tumor suppressor in many tumors. We aimed to investigate prognostic significance ARID1A expression gastric cancers and explore its relationship with clinicopathologic parameters such as mismatch repair protein expression.Four tissue microarrays were constructed from 191 resected specimens obtained at...
Fabry disease is a lysosomal storage with an X-linked heritage caused by absent or decreased activity of enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations disease, nephropathy significantly affects patients’ morbidity and mortality. The cellular mechanisms kidney damage have not been elusively described. Necroptosis one programmed necrotic cell death pathways known to play many important roles in injury. We investigated whether RIPK3, protein phosphokinase role...
MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This characterized giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed 30% of patients with disorder. The characteristic features are early onset proteinuria rapidly progressing renal However, prognosis nephropathy remains unclear. Herein, we...
Solitary fibrous tumors (SFTs) are unique soft-tissue of submesothelial origin. These mainly located in the pleural space but they can be originated within a variety sites, including abdomen, pelvis, soft tissues and retroperitoneum. SFTs from all sites usually benign, surgical resection is curative almost cases. According to review literatures, during resection, massive hemorrhage could occur due hypervascular nature SFTs. This case report on SFT pelvis presenting great vessel injury, which...
A glomus tumor in the mediastinum is very uncommon, and only five cases have been reported English literature. We recently encountered a 21-year-old woman with an asymptomatic mediastinal mass that measured 5.3 × 4.0 cm. Surgical excision was performed, finally diagnosed as uncertain malignant potential. After reviewing this case previous reports, we analyzed clinicopathologic features associated progression of such tumor.
PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated expression gastric cancer explored the relationships between level clinicopathological features as well survival patients.We examined tissue microarray 178 adenocarcinomas by immunohisto-chemistry reviewed patients' medical records.In our study, 112 patients displayed positive expression. Overexpression was correlated with low grade differentiation (P=0.001),...
Abstract The role of the conserved focal adhesion kinase (FAK) family protein tyrosine kinases in development and physiological functions CNS has long been an area interest among neuroscientists. In this report, we observe that Drosophila mutants lacking Fak56 exhibit a decreased lifespan, accompanied by bang‐sensitive phenotype, which is characterized sensitivity to mechanical high‐frequency electrical stimulation. mutant animals display lower thresholds higher rates seizures response...
Angiomotin ( AMOT ) promotes angiogenesis and plays a role in neovascularization during tumorigenesis. Recently, the isoform, ‐p130, was shown to exert regulatory effect on Yes‐associated protein 1 YAP 1), major downstream effector of Hippo pathway. The specific roles ‐p130 advanced gastric cancer AGC are yet be established. In this study, total 166 patients with were enrolled, levels analyzed by immunohistochemistry using tissue microarrays. Low together high expression (n = 30, 18.1%)...
All types of membranoproliferative glomerulonephritis (MPGN) are progressive diseases with poor prognoses. Recently, a newly proposed classification these separated them into immune complex- and complement-mediated diseases. We investigated the frequency C3 among previously diagnosed MPGN patients.We conducted retrospective study patients at three tertiary care institutions between 2001 2010. incidence disease MPGN. Progressive renal dysfunction was defined as 50% reduction in glomerular...
Purpose:The aims of this study were to evaluate the expression large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining gastric cancer, clinicopathological significance LATS its correlation with overall survival (OS).Materials Methods: in a tissue microarray was detected immunohistochemistry, using 264 cancer specimens surgically resected between July 2006 December 2009.Results: Low significantly associated more advanced American Joint Committee on Cancer (AJCC)...
Transducer-like enhancer of split 1 (TLE1) is a member the Groucho/TLE family transcriptional co-repressors that regulate activity numerous genes. TLE1 involved in tumorigenesis various tumors. We investigated prognostic significance expression and its association with clinicopathological parameters gastric cancer (GC) patients.Immunohistochemical analysis six tissue microarrays was performed to examine using 291 surgically resected GC specimens from Soonchunhyang University Cheonan Hospital...
Proteinuria is a significant risk factor for progression of IgA nephropathy (IgAN) and has positive correlation with severity foot process effacement (FPE). We evaluated the relationship FPE proteinuria histologic characteristics, including Oxford classification.Patients who underwent renal biopsy were diagnosed IgAN at single center retrospectively reviewed. Patients aged less than 18 years those possibility secondary causes excluded from study. Subsequently, we association between degree...
The relationship between 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) textural features and histopathological findings in gastric cancer has not been fully evaluated. We investigated the of primary tumors on FDG PET/CT with recurrence-free survival (RFS) patients advanced (AGC). Fifty-six AGC who underwent for staging work-ups were retrospectively enrolled. Conventional parameters first- second-order extracted using PET analysis. Upon...
2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake of the reticuloendothelial system, including bone marrow (BM) and spleen, on positron emission tomography/computed tomography (PET/CT) has been shown to be a significant prognostic factor in diverse malignancies. However, relationship between FDG BM spleen histopathological findings, tumor immune microenvironment, not fully evaluated. This study aimed investigate with findings recurrence-free survival (RFS) patients gastric cancer. Seventy cancer...