A5100656175- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Chemokine receptors and signaling
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- interferon and immune responses
- Hormonal Regulation and Hypertension
- Plant Pathogenic Bacteria Studies
- Laser Applications in Dentistry and Medicine
- Inflammatory mediators and NSAID effects
- Heat shock proteins research
- Plant-Microbe Interactions and Immunity
- Immune Response and Inflammation
- Ion Transport and Channel Regulation
- Receptor Mechanisms and Signaling
- Seaweed-derived Bioactive Compounds
- Nutrition, Health and Food Behavior
- Quinazolinone synthesis and applications
- Otitis Media and Relapsing Polychondritis
- Bioactive natural compounds
- Natural Compounds in Disease Treatment
- Ear Surgery and Otitis Media
Pusan National University Yangsan Hospital
2023-2025
Hallym Polytechnic University
2024
Chungbuk National University
2023-2024
Hallym University
2022-2024
Pusan National University
2003-2023
Jeonbuk National University
2023
Seoul National University
2020-2022
University of Maryland, Baltimore
2008-2015
Honam University
2015
Maryknoll Medical Center
2013
The antioxidative effects of mulberroside A and oxyresveratrol obtained from Mori Cortex were examined. Mulberroside showed an inhibitory effect against FeSO4/H2O2-induced lipid peroxidation in rat microsomes a scavenging on 1,1-diphenyl-2-picrylhydrazyl radical. anti-inflammatory using the carrageenin-induced model inflammation investigated rats. significantly reduced paw edema. To investigate mechanism action these compounds, we examined lipopolysaccharide (LPS)-induced responses murine...
Introduction Rheumatoid arthritis (RA) is a chronic destructive inflammatory disease that afflicts over one percent of the world’s population. Current pharmacological treatments remain relatively ineffective. In this context, photobiomodulation (PBM) potential resource for treatment RA. This study investigates investigate anti-arthritic effects and related mechanisms PBM on fibroblast-like synoviocytes (FLSs) from RA patients mouse model collagen-induced (CIA). Methods The RA-FLSs were...
Exposure to particulate matter (PM), especially PM
Particulate matter (PM) is a harmful air pollutant associated with respiratory and cardiovascular diseases, but its effects on adaptive immunity are poorly understood. This study investigates the role of NRF2 in T cells mediating immune pulmonary responses to long-term PM exposure, highlighting impact inhalation toxicity. To establish mouse model lung injury induced by C57BL/6 mice were intranasally administered 20 μg/kg PM10 or PM2.5 daily for 16 weeks. Lung parameters analyzed...
Molecular mechanisms underlying the decreased number of macrophages and T cells in arteries cholesterol-fed-rabbits following dexamethasone administration are unknown. We investigated possibility that could affect activation monocytic induced by oxygenated derivatives cholesterol (oxysterols) using THP-1 monocyte/macrophage cells. 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production CCL2, known as MCP1, chemokine from monocytes/macrophages...
Microglia, essential immune cells in the brain, play crucial roles neuroinflammation by performing various functions such as neurogenesis, synaptic pruning, and pathogen defense. These are activated inflammatory factors like β-amyloid (Aβ) oxysterols, leading to morphological functional changes, including secretion of cytokines upregulation MHC class II molecules. This study focused on identifying specific markers for microglial activation, with a particular emphasis oxysterols this process....
Lettuce (Lactuca sativa L.) contains various bioactive compounds that can reduce the severity of inflammatory diseases. This study aimed to identify therapeutic effects and underlying mechanisms fermented lettuce extract (FLE) containing stable nitric oxide (NO) on collagen-induced arthritis (CIA) in mice fibroblast-like synoviocytes (MH7A line) from patients with rheumatoid (RA). DBA/1 were immunized bovine type II collagen orally administered FLE for 14 days. On day 36, mouse sera ankle...
We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7α-hydroxycholesterol (7αOHChol), 7β-hydroxycholesterol (7βOHChol), and 7-ketocholesterol (7K), on IL-8 expression. Transcript levels secretion its corresponding gene product by monocytes/macrophages were enhanced treatment with 7αOHChol and, to a lesser extent, 7K, but not 7βOHChol. The derivatives, however, did change transcription the vascular smooth muscle cells. 7αOHChol-induced was...
Oxysterol like 27‐hydroxycholesterol (27OHChol) has been reported to induce differentiation of monocytic cells into a mature dendritic cell phenotype. We examined whether dexamethasone (Dx) affects 27OHChol‐induced using THP‐1 cells. Treatment with Dx resulted in almost complete inhibition transcription and surface expression CD80, CD83, CD88 induced by 27OHChol. Elevated levels MHC class I II molecules 27OHChol were reduced basal treatment Dx. A decreased endocytosis ability caused was...
Abstract Every year, despite the use of chemicals, significant crop loss is caused by pathogenic microbes. Plant innate resistance to pathogens depends on two sets genetically encoded immune receptors that sense invaders and trigger signaling cascades leading reinforcement physical barriers production various antimicrobial compounds. In past 30 years, molecular cloning characterization plant have deepened our understanding system more importantly, provided means improve protection against...
We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on 27-hydroxycholesterol (27OHChol)-induced differentiation monocytic into mature dendritic (mDCs). Treatment human THP-1 with antagonized 27OHChol attenuating dendrite formation and cell attachment promoting endocytic function. Diclofenac inhibited transcription surface expression mDC markers CD80, CD83, CD88, reduced...
exhibits agonistic activity for liver X receptors (LXRs).To determine roles of the LXR in macrophage gene expression, we investigated effects inhibition on 27OHChol-induced genes.Treatment human THP-1 cells with GSK 2033, a potent cell-active antagonist, results complete transcription target genes (such as LXRα and ABCA1) induced by 27OHChol or synthetic ligand TO 901317.Whereas expression CCL2 CCL4 remains unaffected TNF-α is further CCL3 CXCL8 are suppressed at both transcriptional protein...
Miconazole is effective in treating inflammatory skin conditions and has well-established antifungal effects. To elucidate the underlying mechanisms mediating its additional beneficial effects, we assessed whether miconazole influences inflammation induced by 27-hydroxycholesterol (27OHChol), an oxygenated cholesterol derivative with high proinflammatory activity, using THP-1 monocytic cells. dose-dependently inhibited expression of markers, including CCL2 CCR5 ligands such as CCL3 CCL4,...