A5052951292- Cholesterol and Lipid Metabolism
- Ginger and Zingiberaceae research
- Cancer, Lipids, and Metabolism
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Antioxidant Activity and Oxidative Stress
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammasome and immune disorders
- Mast cells and histamine
Pusan National University
2023-2024
Three models of hypercholesterolemia in rabbits were positively associated with plasma cholesteryl ester and triglyceride transfer activities. In cholesterol-fed rabbits, the activities increased two- to three-fold when cholesterol concentration reached about 1500 mg/dl. induced by feeding a cholesterol-free semisynthetic casein-sucrose diet, up increase per unit increment was similar that rabbits. Watanabe heritable hyperlipidemic which is genetic defect LDL receptor, had significantly...
Astaxanthin (3,3'-dihydroxy-β,β-carotene-4,4'-dione; AXT) is a xanthophyll β-carotenoid found in microalgae, seafood, fungi, complex plants, flamingos, and quail. It well known that AXT plays role as drug with antioxidant antitumor properties. Furthermore, several studies have reported the reagent shows anti-inflammatory neuroprotective effects. Recently, it was acts peroxisome proliferator-activated receptor γ (PPARγ) modulator. To investigate effect of on MCF-7 cells (a human breast cancer...
In individuals with Alzheimer’s disease, the brain exhibits elevated levels of IL-1β and oxygenated cholesterol molecules (oxysterols). This study aimed to investigate effects side-chain oxysterols on expression using HMC3 microglial cells ApoE-deficient mice. Treatment 25-hydroxycholesterol (25OHChol) 27-hydroxycholesterol (27OHChol) led increased at transcript protein levels. Additionally, these upregulated surface MHC II, a marker activated microglia. Immunohistochemistry performed mice...
Microglia, essential immune cells in the brain, play crucial roles neuroinflammation by performing various functions such as neurogenesis, synaptic pruning, and pathogen defense. These are activated inflammatory factors like β-amyloid (Aβ) oxysterols, leading to morphological functional changes, including secretion of cytokines upregulation MHC class II molecules. This study focused on identifying specific markers for microglial activation, with a particular emphasis oxysterols this process....
Glucocorticoids suppress the vascular inflammation that occurs under hypercholesterolemia, as demonstrated in an animal model fed a high-cholesterol diet. However, molecular mechanisms underlying these beneficial effects remain poorly understood. Because cholesterol is oxidized to form oxides (oxysterols) are capable of inducing inflammation, we investigated whether glucocorticoids affect immune responses evoked by 7α-hydroxycholesterol (7αOHChol). The treatment human THP-1 monocytic cells...
Atherosclerosis is characterized by the deposition and accumulation of extracellular cholesterol inflammatory cells in arterial blood vessel walls, 27-hydroxycholesterol (27OHChol) most abundant metabolite. 27OHChol an oxysterol that induces immune responses, including cell activation chemokine secretion, although underlying mechanisms are not fully understood. In this study, we investigated roles mechanistic target rapamycin (mTOR) 27HChol-induced inflammation using rapamycin. Treating...
Microglia play a crucial role as immune cells responsible for the brain’s defense mechanisms. Similar to actions of macrophages in body, microglial elicit an inflammatory response brain. Recent papers highlight activated pivotal contributors responses brain, leading damage nerve tissue and onset Alzheimer’s disease (AD). In brains AD patients, elevated levels cytokines such interleukin-6 (IL-6) oxidized cholesterol metabolites (oxysterols) are observed. These factors closely associated with...