A5018715414- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Exercise and Physiological Responses
- HIV Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Inflammasome and immune disorders
- Tensor decomposition and applications
- Childhood Cancer Survivors' Quality of Life
- Phytochemical compounds biological activities
- Physiological and biochemical adaptations
- Phagocytosis and Immune Regulation
- interferon and immune responses
- RNA regulation and disease
- Surgical Simulation and Training
- Monoclonal and Polyclonal Antibodies Research
- Nanowire Synthesis and Applications
Pusan National University Yangsan Hospital
2025
Pusan National University
2015-2024
Korea University
2004-2023
National Cancer Institute
2010-2020
National Institutes of Health
2010-2020
Center for Cancer Research
2020
University of Nebraska–Lincoln
1987
Interleukin-7 (IL-7) is an essential cytokine for T cells.However, IL-7 not produced by cells themselves such that are dependent on extrinsic IL-7.In fact, in the absence of IL-7, cell development thymus as well survival naive periphery severely impaired.Furthermore, modulating availability vivo either genetic means or other experimental approaches determines size, composition and function pool.Consequently, understanding expression critical immunity.Until most recently, however,...
Particulate matter (PM) is a harmful air pollutant associated with respiratory and cardiovascular diseases, but its effects on adaptive immunity are poorly understood. This study investigates the role of NRF2 in T cells mediating immune pulmonary responses to long-term PM exposure, highlighting impact inhalation toxicity. To establish mouse model lung injury induced by C57BL/6 mice were intranasally administered 20 μg/kg PM10 or PM2.5 daily for 16 weeks. Lung parameters analyzed...
Cytotoxic T lymphocytes (CTLs) play a crucial role in cancer rejection. However, CTLs encounter dysfunction and exhaustion the immunosuppressive tumor microenvironment (TME). Although reactive oxygen species (ROS)-rich TME attenuates CTL function, underlying molecular mechanism remains poorly understood. The nuclear factor erythroid 2-related 2 (Nrf2) is ROS-responsible implicated increasing susceptibility to progression. Therefore, we examined how Nrf2 involved anti-tumor responses of CD8
All T cells are dependent on IL-7 for their development and homeostasis. Foxp3(+) regulatory (Tregs) unique among in that they IL-2. Whether such IL-2 dependency is distinct from or addition to an requirement has been a confounding issue, particularly because of the absence adequate experimental system address this question. In study, we present novel vivo mouse model where expression intact but was geographically limited thymus. Consequently, not available peripheral tissues. Such mice were...
Understanding the homeostatic mechanism of invariant natural killer T (iNKT) cells is a critical issue in iNKT cell biology. Because interleukin (IL)-15 required for thymic generation cells, IL-15 has also been considered necessary homeostasis peripheral cells. Here, we delineated vivo cytokine requirement and came to surprising conclusion that IL-7, not IL-15, Employing series experimental mouse models where availability IL-7 or was manipulated tissues, either by genetic tools adult...
Abstract NKT cells perform crucial roles in tumor surveillance, functioning as regulators of early host response. In this study, we have assessed the effects activation at time Ag immunization, and evaluated contributions CD4+ CD8+ T rejection during adaptive immune response against live cells. Our data indicate that play critical roles, not only assisting CTL, but also orchestration tumor. The were found to reject transplanted very efficiently under conditions which CTLs removed either...
Abstract The soluble γc protein (sγc) is a naturally occurring splice isoform of the cytokine receptor that produced by activated T cells and inhibits signaling. Here we show sγc expression also highly upregulated in immature CD4 + CD8 thymocytes but then downregulated mature thymocytes. These results indicate developmentally controlled mechanism for suggest potential role regulating cell development thymus. Indeed, overexpression resulted significantly reduced thymocyte numbers diminished...
IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts IL-7-proprietary IL-7Rα so that they are impaired in signaling. Because cells depend on IL-2, loss has been considered irrelevant In contrast, here, we report downregulation necessary to maximize IL-2R Although overexpression promoted signaling, unexpectedly, IL-2 was suppressed same Mechanistically, found γc, which a...
AS a part of our ongoing search for safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature certain tumor antigens would influence immune responses against cells. As compared with freeze-thawed or formaldehyde-fixed antigens, heat-denatured elicited profound greatly inhibited growth live The induced substantial increase in CTL response absence any adjuvant material. This appears be initiated by strong activation antigen-presenting cells, which may...
The physiologic function of natural killer T (NKT) cells in adaptive immunity remains largely unknown because most studies have used NKT cell agonists. In the present study, role during secondary effector phase was investigated separately from primary immunization via adoptive transfer differentiated into naive recipients. We found that antitumor CD8(+) T-cell responses were optimal when present. Tumor-specific responded less strongly to tumor challenge cell-deficient recipients than with...
// Tae-Wook Chung 1, 2, * , Hee-Jung Choi Mi-Ju Park 1 Hee-Jin 2 Syng-Ook Lee 3 Keuk-Jun Kim 4 Cheorl-Ho 5 Changwan Hong 6 Kyun-Ha Myungsoo Joo Ki-Tae Ha Korean Medical Research Center for Healthy Aging and Yangsan, Gyeongsangnam-do, Republic of Korea School Medicine, Pusan National University, Department Food Science Technology, Keimyung Daegu, Clinical Pathology, TaeKyeung Gyeongsan, Gyeongsangbuk-do, Biological Science, Sungkyunkwan Suwon, Kyunggi-do, Anatomy, These authors contributed...
Invariant natural killer T (iNKT) cells develop in the thymus upon recognition of CD1d expressed on developing thymocytes. Although CD4 and CD8 coreceptors are not directly involved interaction between cell receptors (TCRs) iNKT cells, a conspicuous lack CD8+ mice raised question whether excluded due to negative selection during their thymic development, or if there is no lineage commitment for development murine cells. To address this question, we analyzed cell-specific TCR Vα14+ transgenic...
Abstract NKT cells are considered to be innate-like regulatory cells. However, their functions in adaptive immune responses have not been studied detail. In this study, we investigated the immunoregulatory of during secondary phase an Ag-specific CD4+ T cell response. When compared with OVA-specific effector adoptively transferred into cell-deficient naive CD1d−/− mice, same CD1d+/− mice exhibited substantially stronger on OVA challenge. The enhanced response presence correlated increase...
γ-Chain (γc) cytokine receptor signaling is required for the development of all lymphocytes. Why γc plays such an essential role not fully understood, but induction serine/threonine kinase Pim1 considered a major downstream event as prevents apoptosis and increases metabolic activity. Consequently, we asked whether overexpression would suffice to restore lymphocyte in γc-deficient mice. By analyzing Pim1-transgenic mice (Pim1(Tg) γc(KO) ), show that promoted T-cell survival absence γc....
Despite the broad rehabilitative potential of aquatic exercises, relationship between exercise and immune system has not been fully elucidated to date. In particular, there are few specific delicate immunological approaches effect water temperature on immunity. Thus, we examined immunity during exercise. The animal tumor model was adopted examine impact at thermoneutral (TT; 29°C) compared with body (BT; 36°C). Tumor-bearing mice were made swim in TT or BT for 3 wk cells their functional...