A5103048248- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Endometriosis Research and Treatment
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- CNS Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Brain Metastases and Treatment
- Kruppel-like factors research
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Bone and Dental Protein Studies
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Glioma Diagnosis and Treatment
- Vitamin D Research Studies
- Infant Nutrition and Health
- Multiple Myeloma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Supramolecular Self-Assembly in Materials
Cornell University
2015-2024
Weill Cornell Medicine
2016-2024
Institute for Biomedicine
2022
New York Proton Center
2022
New York Genome Center
2018-2022
National Institute of Dental and Craniofacial Research
2018
National Institutes of Health
2013-2018
New York Hospital Queens
2016
Presbyterian Hospital
2016
NewYork–Presbyterian Hospital
2016
Some secreted proteins that assemble into large complexes, such as extracellular matrices or hormones and enzymes in storage granules, must be kept at subaggregation concentrations during intracellular trafficking. We show surfeit locus protein 4 (Surf4) is the cargo receptor establishes different steady-state for a variety of soluble within endoplasmic reticulum (ER) through interaction with amino-terminal tripeptides exposed after removal leader sequences. call this motif ER-Exit by...
Macrophages maintain hematopoietic stem cell (HSC) quality by assessing surface Calreticulin (Calr), an “eat-me” signal induced reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as a crucial “don’t eat-me” on blood cells. A chemical screen revealed inducers of Calr that promoted HSC proliferation without triggering ROS or macrophage clearance. Whole-genome CRISPR-Cas9 screening showed Toll-like receptor 3 (Tlr3) signaling regulated b2m...
Problem The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels patients with endometriosis. Method A total 79 histologically confirmed endometriosis 43 without participated study. endometrial tissues measured by real‐time quantitative polymerase chain reaction (PCR) concentrations were quantified using a specific commercial sandwich enzyme‐linked immunosorbent assays (ELISA). Results Osteopontin tissue significantly higher women...
BACKGROUNDNon-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) is involved in cellular processes such as inflammation, apoptosis and tumorigenesis. However, little known about the expression function of NAG-1 endometrium. This study aimed to evaluate endometrium absence or presence endometriosis investigate effect celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, on mRNA levels human endometrial stromal cells (HESCs).
γ-Chain (γc) cytokine receptor signaling is required for the development of all lymphocytes. Why γc plays such an essential role not fully understood, but induction serine/threonine kinase Pim1 considered a major downstream event as prevents apoptosis and increases metabolic activity. Consequently, we asked whether overexpression would suffice to restore lymphocyte in γc-deficient mice. By analyzing Pim1-transgenic mice (Pim1(Tg) γc(KO) ), show that promoted T-cell survival absence γc....
ABSTRACT Somatic mutations in cancer genes have been ubiquitously detected clonal expansions across healthy human tissue, including hematopoiesis. However, mutated and wildtype cells are morphologically phenotypically similar, limiting the ability to link genotypes with cellular phenotypes. To overcome this limitation, we leveraged multi-modality single-cell sequencing, capturing mutation transcriptomes methylomes stem progenitors from individuals DNMT3A R882 resulted myeloid over lymphoid...
Most of the proposed extracellular biomineralization processes include secretion proteins that interact with mineral ions and/or surfaces. Typically these are acidic or have domains multivalent cations in environment. We propose most acidic, Ca2+-binding challenge cell's mechanisms for trafficking through endoplasmic reticulum (ER) lumen due to lumenal mM calcium cause them form large aggregates. recently shown >95% DSPP mutations non-syndromic genetic dentin diseases start their dominant...
Abstract Defining the transcriptomic identity of clonally related malignant cells is challenging in absence cell surface markers that distinguish cancer clones from one another or admixed non-neoplastic cells. While single-cell methods have been devised to capture both transcriptome and genotype, these are not compatible with droplet-based transcriptomics, limiting their throughput. To overcome this limitation, we present Genotyping Transcriptomes (GoT), which integrates cDNA genotyping...