A5049703375- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Renal and related cancers
- Pancreatic function and diabetes
- Lysosomal Storage Disorders Research
- Antimicrobial Peptides and Activities
- HIV/AIDS Research and Interventions
- S100 Proteins and Annexins
- Genomics and Chromatin Dynamics
- Proteoglycans and glycosaminoglycans research
- HIV Research and Treatment
- Neonatal Respiratory Health Research
- Neuropeptides and Animal Physiology
- Genetic and Kidney Cyst Diseases
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- bioluminescence and chemiluminescence research
- Protease and Inhibitor Mechanisms
- Protist diversity and phylogeny
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Urological Disorders and Treatments
- RNA and protein synthesis mechanisms
Ulsan National Institute of Science and Technology
2015-2025
Institute for Basic Science
2018
Korea National Institute of Health
2012
ITGBL1 promotes chondrogenesis and protects joint cartilage from osteoarthritis by inhibiting integrin-extracellular matrix interaction.
Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, ER-associated degradation (ERAD) complex-which removes misfolded unfolded proteins to maintain proteostasis ER- plays an indispensable role building maintaining cartilage. Here, we examined necessity of ERAD complex chondrocytes for cartilage formation maintenance. We show gene expression is exponentially increased during chondrogenesis,...
Other SectionsAbstractINTRODUCTIONEXTRACELLULAR MATRIXES IN CNSLECTICAN, THE SULFATED PROTEOGLYCAN NEURONAL ECMSAGGRECANVERSICANBREVICANNEUROCANLECTICANS AND NEUROINFLAMMATIONHYALURONAN (HYALURONIC ACID; HA)HYALURONAN NEUROINFLAMMATIONTENASCINSTENASCINS NEUROINFLAMMATIONCONCLUSIONACKNOWLEDGEMENTSCONFLICTS OF INTERESTReferences
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology cytosolic HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, seems to play critical roles in metabolic processes energy production, such glycolysis and β-oxidation. also reported direct target of PTEN-induced kinase 1 (PINK1) may be cause Parkinson's disease (PD) humans. Although the biochemical are under...
Abstract The first Asian community conference on “Scientific research using Xenopus as an animal model system” was held in Osaka, Japan, from November 24 to 26, 2024. This event organized by the Korean Society for Development of KSMCB (Korean Molecular and Cellular Biology), Community Japan (XCIJ), KNU G‐LAMP Project, National BioResource Project—Clawed frogs/Newts (NBRP), Osaka University. covered various topics biological sciences . ultimate goal this promote collaboration encourage a new...
Abstract Cannabinoid 1 receptors ( CB 1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse β‐cell lines, human and 1R‐null CB1R −/− ) mice, we have now investigated the role 1Rs modulating function glucose responsiveness. Synthetic 1R agonists diminished GLP ‐1‐mediated cAMP accumulation insulin secretion as well glucose‐stimulated lines islets. In addition, silencing β cells resulted an increased expression...
Abstract Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of ERAD machinery, plays an important role in selecting transporting substrates for degradation. We have determined crystal structure mouse SEL1L central domain comprising five S el1- L ike R epeats (SLR motifs 5 to 9; hereafter called cent ). Strikingly, forms homodimer with two-fold symmetry head-to-tail manner. Particularly,...
Abstract Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes reduction H 2 O and alkyl hydroperoxide plays important role in different biological processes. also participates various age-related diseases cancers. In this study, we investigated pronephros development during embryogenesis. knockdown markedly inhibited proximal tubule formation significantly increased cellular levels reactive oxygen species (ROS), which impaired...
Motile cilia of multiciliated epithelial cells have important roles in animal development and cell homeostasis. Although several studies identified reported proteins localized this complex organelle the related immotile primary from various types, it is still challenging to isolate high quantities ciliary for proteomic analysis. In study, African clawed frog (Xenopus laevis) embryos, which many epidermis, were treated with a simple ionic buffer identify 1009 conserved across vertebrates;...
The airway epithelium in human plays a central role as the first line of defense against environmental contaminants. Most respiratory diseases such chronic obstructive pulmonary disease (COPD), asthma, and infections, disturb normal muco-ciliary functions by stimulating hypersecretion mucus. Several muco-active agents have been used to treat symptoms patients. Current reagents control mucus secretion modulating either inflammation, cholinergic parasympathetic nerve activities or reducing...
Abstract Exposure to particulate matter (PM) in ambient air is known increase the risk of cardiovascular disorders and mortality. The cytotoxicity PM mainly due abnormal reactive oxygen species (ROS), which damage cellular components such as DNA, RNA, proteins. correlation between exposure human disorders, including mortality, based on long-term exposure. In this study we have investigated acute responses mucus-secreting goblet cells upon derived from a heavy diesel engine. To end, employed...
The detection of HIV seroconverters increased annually since antigen/antibody testing kits have been available widely in South Korea. This study aimed to identify the epidemiological characteristics and their immune level at diagnosis.We analyzed immunological 341 among 6,008 HIV-diagnosed individuals from 1999 2009. analysis factors was conducted by using chi-square test on SAS version 9.1.The newly-identified cases each year 0.5% over 5% or sex ratio 18:1 (male:female), 33% were 30s, 28%...