A5100326323- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Nanoparticles: synthesis and applications
- NF-κB Signaling Pathways
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Healthcare Education and Workforce Issues
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Per- and polyfluoroalkyl substances research
- Immune cells in cancer
- Bone Metabolism and Diseases
- Hops Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Psoriasis: Treatment and Pathogenesis
- Technology Adoption and User Behaviour
- Bone health and treatments
Dankook University
2024-2025
Kyungpook National University
2015-2024
Korea University
2013-2024
Chungbuk National University
2017-2024
Korea Research Institute of Bioscience and Biotechnology
2013-2024
Keimyung University
2008-2022
Hannam University
2021-2022
Hanbuk University
2019
University of Dundee
2016-2017
NYU Langone Health
2016-2017
Abstract Activated microglia are thought to undergo apoptosis as a self-regulatory mechanism. To better understand molecular mechanisms of the microglial apoptosis, apoptosis-resistant variants cells were selected and characterized. The expression lipocalin 2 (lcn2) was significantly down-regulated in that resistant NO-induced apoptosis. lcn2 increased by inflammatory stimuli microglia. stable well addition rLCN2 protein augmented sensitivity while knockdown using short hairpin RNA...
Abstract In the present study, we investigated neurotoxicity of bisphenol A [BPA; 2,2‐bis‐(4 hydroxyphenyl) propane] and underlying mechanisms action in mouse hippocampal HT‐22 cells. BPA, known to be a xenoestrogen, is used production water bottles, cans, teeth suture materials. BPA‐treated cells showed lower cell viability than did controls at concentrations BPA over 100 μM. induced apoptotic death as indicated by staining with Hoechst 33258, costaining Annexin V/propidium iodide,...
Klebsiella pneumoniae is an important cause of nosocomial Gram-negative sepsis. Lipopolysaccharide (LPS) considered to be a major virulence determinant this encapsulated bacterium and most mutations the lipid A anchor LPS are conditionally lethal bacterium. We studied role acylation in K. disease pathogenesis by using mutation lpxM (msbB/waaN), which encodes enzyme responsible for late secondary immature molecules. B5055 (K2:O1) mutant was found attenuated growth lungs mouse pneumonia model...
Abstract The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether corona NPs influences This study clarified that response mediated by is greatly dependent on type of surrounding NPs. Structural changes in unfolded elevated reactive oxygen species (ROS) levels and induced major proinflammatory cytokine release both murine human macrophage cell lines. In contrast, negligible...
Adiponectin predominantly secreted from adipose tissue has exhibited potent anti‐proliferative properties in cancer cells via modulating cell cycle and apoptosis. FoxO3A, a Forkhead box O member of the transcription factor, plays critical role expression genes involved death and/or survival. In this study, we investigated FoxO3A signaling anti‐cancer activities adiponectin. Herein, have shown that treatment with globular adiponectin (gAcrp) increases p27 but decreases cyclinD1 human hepatoma...
Abstract Tolerogenic dendritic cells (tDCs) represent a promising tool for cellular therapy against autoimmune diseases, allergies, and transplantation rejection. Numerous pharmacological agents are known to induce tDC generation. Minocycline, which has long been used as broad-spectrum antibiotic, was recently shown significantly increase the generation of DCs with regulatory properties. Here, we examined effect combination minocycline dexamethasone, rapamycin, vitamin D3, interleukin...
The inflammasome acts as a key platform for the activation of pro-inflammatory cytokines. Adiponectin exhibits potent anti-inflammatory properties. However, effect adiponectin on modulation has not been explored. Herein, we show that globular (gAcrp) suppressed lipopolysaccharide (LPS)-primed inflammasomes in murine peritoneal macrophages judged by prevention interleukin-1β (IL-1β) maturation, caspase-1 activation, apoptosis-associated speck-like protein containing caspase recruitment domain...
Exosomes are small extracellular membrane vesicles released from endosomes of various cells and could be found in most body fluids. The main functions exosomes have been recognized as important mediators intercellular communication potential biomarkers disease states. This study investigated whether exogenous mice with acetaminophen (APAP)-induced liver injury can damage the recipient hepatic or promote hepatotoxicity mice. We observed that derived APAP-exposed were internalized into primary...
Purpose: Dexamethasone (Dex) has long been used as a potent immunosuppressive agent in the treatment of inflammatory and autoimmune diseases, despite serious side effects. In present study, Dex model antigen ovalbumin (OVA) were encapsulated with poly(lactic-co-glycolic acid) to deliver OVA preferentially phagocytic cells, reducing systemic effects Dex. The OVA-specific immune tolerance-inducing activity nanoparticles (NPs) was examined. Methods: Polymeric NPs containing (NP[OVA+Dex])...
Three new compounds, a diarylheptanone glucoside (1), 4,5,8-trihydroxy-α-tetralone 5-O-β-d-[6'-O−(3'',5''-dimethoxy-4''-hydroxybenzoyl)]glucopyranoside (2), and 1,4,8-trihydroxy-3-naphthalenecarboxylic acid 1-O-β-d-glucopyranoside methyl ester (3), were isolated from the roots of Juglans mandshurica, their structures elucidated on basis spectroscopic studies including 2D-NMR.
Perfluorooctanoic acid (PFOA) has been used in commercial applications and detected environmental matrices. This study focuses on whether PFOA affects the function of immune organs (spleen thymus). Male ICR mice were exposed to 0, 2, 10, 50, 250 ppm drinking water for 21 days. differently altered T lymphocyte populations. In spleen, all doses decreased CD8(+) lymphocytes; CD4(+) lymphocytes increased by 50 PFOA. Exposure thymus. histopathological evaluation, spleen PFOA-treated groups...