A5032745527- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Advanced Image and Video Retrieval Techniques
- Dermatology and Skin Diseases
- Multimodal Machine Learning Applications
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Eosinophilic Disorders and Syndromes
- Mesenchymal stem cell research
- Domain Adaptation and Few-Shot Learning
- Video Analysis and Summarization
- 3D Printing in Biomedical Research
- Psoriasis: Treatment and Pathogenesis
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Immune cells in cancer
- Music and Audio Processing
- Genetic factors in colorectal cancer
- Erythrocyte Function and Pathophysiology
- Immune Response and Inflammation
- Malaria Research and Control
- Folate and B Vitamins Research
Gachon University
2016-2025
KT&G (South Korea)
2025
Chungnam National University
2024
University of Cincinnati
2014-2024
Samsung (South Korea)
2021-2024
Gachon University Gil Medical Center
2018-2024
University of Cincinnati Medical Center
2024
Korea Advanced Institute of Science and Technology
2002-2023
Seoul National University
2018-2019
Changwon National University
2018
In this paper, we address the problem of unsupervised video summarization that automatically extracts key-shots from an input video. Specifically, tackle two critical issues based on our empirical observations: (i) Ineffective feature learning due to flat distributions output importance scores for each frame, and (ii) training difficulty when dealing with longlength inputs. To alleviate first problem, propose a simple yet effective regularization loss term called variance loss. The proposed...
Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we that down-regulate Th17 cells. cells intestine were markedly increased ΔdblGATA-1 mice lacking eosinophils, an inverse correlation was observed between number of wild-type mice. addition, suppressed vitro differentiation cells, as well...
Recent state-of-the-art active learning methods have mostly leveraged generative adversarial networks (GANs) for sample acquisition; however, GAN is usually known to suffer from instability and sensitivity hyperparameters. In contrast these methods, in this article, we propose a novel framework that call Maximum Classifier Discrepancy Active Learning (MCDAL) takes the prediction discrepancies between multiple classifiers. particular, utilize two auxiliary classification layers learn tighter...
We have previously reported that bone marrow cells (BMCs) participate in the regeneration after liver injury. However, it is not established this result of differentiation hematopoietic stem (HSCs), mesenchymal (MSCs) or combination both. investigated contribution each cell fraction to regenerative process. First, we confirmed transplanted migrate directly injured tissue without dispersing other organs. Next, divided green fluorescent protein (GFP)-expressing BMCs into three populations as...
Abstract Accumulating data have indicated a fundamental role of eosinophils in regulating adipose tissue homeostasis. Here, we performed whole-genome RNA sequencing the small intestinal tract, which suggested presence impaired lipid metabolism eosinophil-deficient ΔdblGATA mice. mice fed high-fat diet (HFD) showed reduced body fat mass, enlargement adipocytes, decreased expression adipogenic genes, and developed glucose intolerance. HFD induced accumulation perigonadal white tissue....
Abstract The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether corona NPs influences This study clarified that response mediated by is greatly dependent on type of surrounding NPs. Structural changes in unfolded elevated reactive oxygen species (ROS) levels and induced major proinflammatory cytokine release both murine human macrophage cell lines. In contrast, negligible...
Abstract Background The endometrium, the inner lining of uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, regeneration damaged endometrial tissues by administrating stem cells only is very challenging due to lack specific microenvironments their low attachment rates at sites injury. In this context, various biomaterial-based scaffolds have been used overcome these limitations providing...
Recent evidence of gut microbiota dysbiosis in the context psoriasis and increased cooccurrence inflammatory bowel disease suggest a close relationship between skin immune responses. Using mouse model induced by Toll-like receptor (TLR) 7 ligand imiquimod, we found that psoriatic dermatitis was accompanied changes small intestine associated with eosinophil degranulation, which impaired intestinal barrier integrity. Inflammatory responses were mice prone to degranulation. Caco-2 human...
Abstract Insulin resistance is a major contributor to the pathogenesis of several human diseases, including type 2 diabetes, hypertension, and hyperlipidemia. Notably, insulin hypertension share common abnormalities, increased oxidative stress, inflammation, organelle dysfunction. Recently, we showed that excess intracellular Ca 2+ , known pathogenic factor in acts as critical negative regulator signaling by forming -phosphoinositides prevent membrane localization AKT, key serine/threonine...
Abstract Eosinophils are abundant in the lamina propria of small intestine, but they rarely show degranulation situ under steady-state conditions. In this study, using two novel mAbs, we found that intestinal eosinophils constitutively expressed a high level an inhibitory receptor signal regulatory protein α (SIRPα)/CD172a and low, significant, tetraspanin CD63, whose upregulation is closely associated with degranulation. Cross-linking SIRPα/CD172a on surface wild-type significantly...
Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and negligible nutritional value humans. However, mechanism adverse effects high-phytate intake on Ca2+ phosphate absorption homeostasis unknown. Here, we show excessive phytate along a low-Ca2+ diet fed rats contributed development nephropathies, renal wasting, loss through tubular dysfunction secondary...
Abstract Apoptotic cells are rapidly engulfed and removed by phagocytes after displaying cell surface eat-me signals. Among many phospholipids, only phosphatidylserine (PS) is known to act as an signal on apoptotic cells. Using unbiased proteomics, we identified externalized phosphatidylinositides (PIPs) signals recognized CD14 + phagocytes. Exofacial PIPs the surfaces of early late-apoptotic were observed in patches blebs using anti-PI(3,4,5)P 3 antibody, AKT- PLCδ PH-domains, protein....
Abstract Hormonal regulation during food ingestion and its association with pain prompted the investigation of impact glucagon-like peptide-1 (GLP-1) on transient receptor potential vanilloid 1 (TRPV1). Both endogenous synthetic GLP-1, as well a GLP-1R antagonist, exendin 9–39, reduced heat sensitivity in naïve mice. GLP-1-derived peptides (liraglutide, exendin-4, 9–39) effectively inhibited capsaicin (CAP)-induced currents calcium responses cultured sensory neurons TRPV1-expressing cell...
Colon cancer is prone to distant metastases other sites and the risk of recurrence relatively high. Therefore, identification liver metastasis-related factors important for diagnosis or treatment colon cancer. The aim this study was identify that are differentially expressed in synchronous solitary metastasis compared primary cancer.Tissues associated with five patients were used mass spectrometry. Identified proteins validated by western blotting. silico analysis performed using STRING...
Visual storytelling is a task of creating short story based on photo streams. Unlike existing visual captioning, aims to contain not only factual descriptions, but also human-like narration and semantics. However, the VIST dataset consists small, fixed number photos per story. Therefore, main challenge fill in gap between with narrative imaginative In this paper, we propose explicitly learn imagine storyline that bridges gap. During training, one or more randomly omitted from input stack,...