A5100406470- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Cancer Cells and Metastasis
- Advanced Sensor and Energy Harvesting Materials
- Orthopedic Infections and Treatments
- Carbon Nanotubes in Composites
- Graphene and Nanomaterials Applications
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Silk-based biomaterials and applications
- biodegradable polymer synthesis and properties
- Vasculitis and related conditions
- Cellular Mechanics and Interactions
- Hydrogels: synthesis, properties, applications
- Bacterial biofilms and quorum sensing
- Organic Electronics and Photovoltaics
- Anatomy and Medical Technology
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Pickering emulsions and particle stabilization
Gachon University
2016-2025
Seoul National University
2009-2025
Duksung Women's University
2023-2024
Korea Institute of Science and Technology
2022
University of Oklahoma
2019
Ajou University
2018
Institute of Molecular Medicine
2016
Gachon University Gil Medical Center
2015
Korea Maritime and Ocean University
2014-2015
Yonsei University
2015
The topographic features of the extracelluar matrix (ECM) lay foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D have promising potentials studying cell interactions with microenvironments in vitro vivo. Detailed facts importance to specialist readers are published as...
Several studies have focused on the regeneration of liver tissue in a two-dimensional (2D) planar environment, whereas actual is three-dimensional (3D). Cell printing technology has been successfully utilized for building 3D structures; however, poor mechanical properties cell-laden hydrogels are major concern. Here, we demonstrate construct and its application to engineering using cell through multi-head tissue/organ system. Polycaprolactone (PCL) was used as framework material because...
Abstract This study describes the microstructure and thermal mechanical properties of poly(hydroxybutyrate‐co‐hydroxyvalerate) (PHB/HV)–organoclay nanocomposites prepared by melt intercalation using Cloisite 30B, a monotallow bis‐hydroxyethyl ammonium‐modified montmorillonite clay. X‐ray diffractometry transmission electron microscopy analyses clearly confirm that an intercalated is formed finely distributed in PHB/HV copolymer matrix because has strong hydrogen bond interaction with...
Poisson's ratio describes the degree to which a material contracts (expands) transversally when axially strained. A with zero does not deform in response an axial strain (stretching). In tissue engineering applications, scaffolding having (ZPR) may be more suitable for emulating behavior of native tissues and accommodating transmitting forces host site during wound healing (or regrowth). For example, beneficial cartilage, ligament, corneal, brain tissues, are known possess ratios nearly...
The swelling properties and thermal transition of hydrogels can be tailored by changing the hydrophilic-hydrophobic balance polymer networks. Especially, poly(N-isopropylacrylamide) (PNIPAm) has received attention as thermo-responsive for tissue engineering because its hydrophobicity property are transited around body temperature (32 °C). In this study, we investigated potential poly(ethylene glycol) diacrylate (PEGDA) a hydrophilic co-monomer crosslinker PNIPAm to enhance biological...
Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has negative Poisson's ratio νxy (NPR). NPR constructs have unique ability to expand transversely when pulled axially, thereby resulting highly-compliant construct. work, used projection stereolithography 3D-print planar sheet composed photosensitive poly(ethylene)...
Abstract In general, osteomyelitis is treated with antibiotics, and in severe cases, the inflammatory bone tissue removed substituted poly (methyl methacrylate) (PMMA) beads containing antibiotics. However, this treatment necessitates re-surgery to remove inserted PMMA beads. Moreover, rifampicin, a primary heat-sensitive antibiotic used for osteomyelitis, deemed unsuitable strategy. Three-dimensional (3D) printing technology has gained popularity, as it facilitates production of...
Due to the morphological resemblance between electrospun nanofibers and extracellular matrix (ECM), fibers have been widely used fabricate scaffolds for tissue regeneration. Relationships scaffold morphologies cells are cell type dependent. In this study, we sought determine an optimum fiber diameter human vascular smooth muscle (VSMC) regeneration in scaffolds. Scaffolds were produced using poly(caprolactone) (PCL) diameters of 0.5, 0.7, 1, 2, 2.5, 5, 7 or 10 μm, VSMC survivals,...
Large-sized or deep skin wounds require substitutes for proper healing without scar formation. Therefore, multi-layered that mimic the genuine anatomy of multiple layers have attracted attention as suitable substitutes. In this study, a novel substitute was developed by combining multi-layer tissue reconstruction method with combination human-derived keratinic extract-loaded nano- and micro-fiber using electrospinning support structure 3D printing. A polycaprolactone PCL/keratin electrospun...
Chronic osteomyelitis is mostly caused by bacteria such as S. aureus, and often treated with oral antibiotics or injections to suppress the bacteria. In severe cases, however, surgical treatment using antibiotic beads metal supports may be required. these surgeries, bacterial attachment lead biofilm formation reduce antibiotics' penetration Reoperation must performed prevent inflammatory reactions resistance. Thus, in this study, we developed a dual-drug-releasing PCL/sodium-alginate-based...
Abstract Background The endometrium, the inner lining of uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, regeneration damaged endometrial tissues by administrating stem cells only is very challenging due to lack specific microenvironments their low attachment rates at sites injury. In this context, various biomaterial-based scaffolds have been used overcome these limitations providing...
Abstract Conventional 2D or even 3D in vitro culture models for human reproductive organs cannot properly recapitulate the bidirectional endocrine crosstalk between uterine endometrium and ovary. This is essential maintaining various physiological features functions of each tissue. Moreover, most female tract also fail to mimic its multicellular structure. We therefore developed a novel ‘dual organ on chip’ that reflects cross-talk complex structures by integrating cellular components both...
A migration of cancer is one the most important factors affecting therapy. Particularly, a study in microgravity environment has gained attention as tool for developing In this study, we evaluated proliferation and two types (adenocarcinoma A549, squamous cell carcinoma H1703) non-small lung cancers (NSCLC) floating with microgravity. When measured NSCLCs (MG) ground-gravity (CONT), although initial adhesion MG was low, normalized rate A549 higher than that CONT. Wound healing results H1703...
Tissue engineering recovers an original function of tissue by replacing the damaged part with a new or organ regenerated using various technologies. This technology uses scaffold to support three‐dimensional (3D) formation. Conventional fabrication methods do not control architecture, pore shape, porosity, interconnectivity scaffold, so it has limited ability stimulate cell growth and generate tissue. 3D printing technologies may overcome these disadvantages traditional methods. These use...
Abstract When the trachea is excessively damaged because of diseases, accidents, or surgery, it difficult to achieve both mucosal reconstruction and structural stability using current technologies. Here, a biomimetic tracheal graft (BTG) developed through hybrid process 3D printing electrospinning polycaprolactone (PCL)polymer. First, flexible PCL frame with high rotation angle prepared printing. Second, nanofibers for are placed inside lumen, microfibers on outside promote blood vessel...