Tayaba Ismail

ORCID: 0000-0001-9970-4793
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About
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Research Areas
  • Cholinesterase and Neurodegenerative Diseases
  • Computational Drug Discovery Methods
  • Renal and related cancers
  • Epigenetics and DNA Methylation
  • Genetic and Kidney Cyst Diseases
  • Redox biology and oxidative stress
  • Developmental Biology and Gene Regulation
  • Enzyme function and inhibition
  • Birth, Development, and Health
  • Glutathione Transferases and Polymorphisms
  • Sulfur Compounds in Biology
  • Synthesis and biological activity
  • Genomics and Chromatin Dynamics
  • Phytochemistry and Biological Activities
  • Genetics and Neurodevelopmental Disorders
  • RNA Research and Splicing
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Psidium guajava Extracts and Applications
  • Toxic Organic Pollutants Impact
  • Connexins and lens biology
  • Cerebrospinal fluid and hydrocephalus
  • Traditional and Medicinal Uses of Annonaceae
  • bioluminescence and chemiluminescence research
  • Plant chemical constituents analysis
  • Protist diversity and phylogeny

Kyungpook National University
2016-2024

Islamia University of Bahawalpur
2013-2016

Cholinesterases (ChEs) play a vital role in the regulation of cholinergic transmission. The inhibition ChEs is considered to be involved increasing acetylcholine level brain and thus has been implicated treatment Alzheimer's disease. We have designed synthesized series novel indole derivatives screened them for acetylcholinesterase (AChE) butyrylcholinesterase (BChE). Most tested compounds exhibited inhibitory activity against AChE BChE. Among 4f 6e showed highest with IC50 91.21±0.06...

10.2174/15701808113106660078 article EN Letters in Drug Design & Discovery 2014-02-01

Abstract Engineered aluminum oxide nanoparticles (Al 2 O 3 NPs) having high‐grade thermal stability and water‐dispersion properties are extensively used in different industries personal care products. Toxicological response evaluation of these NPs is indispensable assessing the health risks exposure limits because their industrial disposal into aquatic environment. We assessed compared developmental toxicity Al Xenopus laevis Danio rerio over a period 96 h using frog embryo teratogenic assay...

10.1002/etc.4584 article EN Environmental Toxicology and Chemistry 2019-08-30

Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for di- tri-demethylation lysine 4 residues on 3 (H3K4 me2/3). KDM5C expressed in brain skeletal muscles humans associated with various biologically significant processes. known be X-linked mental retardation also involved development cancer. However, developmental significance has not been explored yet. In present study, we investigated physiological roles during Xenopus laevis...

10.1186/s13072-018-0241-x article EN cc-by Epigenetics & Chromatin 2018-12-01

Abstract Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes reduction H 2 O and alkyl hydroperoxide plays important role in different biological processes. also participates various age-related diseases cancers. In this study, we investigated pronephros development during embryogenesis. knockdown markedly inhibited proximal tubule formation significantly increased cellular levels reactive oxygen species (ROS), which impaired...

10.1038/s41598-017-09262-6 article EN cc-by Scientific Reports 2017-08-15

The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling filaments increasing globular pools. However, specific developmental roles dstn have yet to be fully elucidated. Here, we investigated physiological functions during early embryonic development using Xenopus laevis as an experimental model organism. expressed in anterior...

10.1016/j.mocell.2024.100076 article EN Molecules and Cells 2024-05-31

Aims: Peroxiredoxin5 (Prdx5), a thioredoxin peroxidase, is an antioxidant enzyme that widely studied for its properties and protective roles in neurological cardiovascular disorders. This study aimed at investigating the functional significance of Prdx5 mitochondria analyzing ciliogenesis during process vertebrate development. Results: We found several Prdx genes were strongly expressed multiciliated cells developing Xenopus embryos, their peroxidatic functions crucial normal cilia Depletion...

10.1089/ars.2018.7507 article EN Antioxidants and Redox Signaling 2018-09-07

Abstract Chromatographic purification of ethyl acetate soluble fraction the methanolic extract flowers Aerva javanica yielded three new acylated flavone glycosides: kaempferol-3-O-β-d-[4‴-E-p-coumaroyl-α-l-rhamnosyl(1 → 6)]-galactoside (1), 6)]-(3″-E-p-coumaroyl)galactoside (2), and 6)]-(4″-E-p-coumaroyl)galactoside (3), along with p-coumaric acid (4), caffeic (5), gallic (6), eicosanyl-trans-p-coumarate (7), hexadecyl ferulate (8), hexacosyl (9). The compounds 1–9 were characterized using...

10.1080/10286020.2013.795553 article EN Journal of Asian Natural Products Research 2013-06-14

Glutathione peroxidase 3 (GPx3) belongs to the glutathione family of selenoproteins and is a key antioxidant enzyme in multicellular organisms against oxidative damage. Downregulation GPx3 affects tumor progression metastasis associated with liver heart disease. However, physiological significance vertebrate embryonic development remains poorly understood. The current study aimed investigate functional roles gpx3 during embryogenesis. To this end, we determined gpx3’s spatiotemporal...

10.3390/antiox9121265 article EN cc-by Antioxidants 2020-12-12

Purpose: To evaluate the enzyme inhibition activity of N-substituted sulfamoyl derivatives 2-amino-1- phenylethane as probable new drug candidates for treatment Alzheimer’s diseases.Methods: A series derivatives, 3a-l, 1-amino-2-phenylethane (1) were synthesized by reacting with various aryl sulfonyl chlorides, 2a-l, in presence aqueous Na2CO3 solution under definite pH control. All molecules screened against three enzymes, acetyl cholinesterase (AChE), butyryl (BChE) and lipoxygenase (LOX)....

10.4314/tjpr.v13i5.13 article EN cc-by Tropical Journal of Pharmaceutical Research 2014-09-10

Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono‑ and di‑methylated ninth of histone 3 belongs to the Jumonji domain‑containing group demethylases. Kdm3a serves roles during various biological pathophysiological processes, including spermatogenesis metabolism, determination sex, androgen receptor‑mediated transcription embryonic carcinoma cell differentiation. In present study, physiological functions were evaluated embryogenesis Xenopus laevis. Spatiotemporal...

10.3892/ijmm.2018.4024 article EN International Journal of Molecular Medicine 2018-12-11

A series of new N-substituted 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl-2"-sulphanyl acetamides was synthesized and enzyme inhibiting activity screened for all these chemical entities.Structural characterization compounds made by IR, EI-MS 1 H NMR. All derivatives demonstrated different extent lipoxygenase (LOX), acetylcholinesterase (AChE) butyrylcholinesterase (BChE).Compounds 6j exhibited excellent inhibitory potential but against the is not appreciable it inactive...

10.14233/ajchem.2013.14333 article EN Asian Journal of Chemistry 2013-01-01

Perfluorooctanesulfonate (PFOS) is a ubiquitous environmental pollutant associated with increasing health concerns and hazards. Toxicological analyses of PFOS exposure are hampered by large interspecies variations limited studies on the mechanistic details PFOS-induced toxicity. We investigated effects Xenopus laevis embryos based reported developmental in zebrafish. X. was selected to further our understanding variation response PFOS, we built upon previous including transcriptomics an...

10.1016/j.ecoenv.2023.115820 article EN cc-by Ecotoxicology and Environmental Safety 2023-12-15

10.1016/j.bbrc.2020.05.009 article EN Biochemical and Biophysical Research Communications 2020-05-16

Pentachloronitrobenzene (PCNB) is an organochlorine fungicide commonly used to treat seeds against seedling infections and controlling snow mold on golf courses. PCNB has been demonstrated be toxic living organisms, including fish several terrestrial organisms. However, only phenotypical deformities have studied, the effects of early embryogenesis, where primary organogenesis occurs, not completely studied. In current study, developmental toxicity teratogenicity evaluated by using frog...

10.1002/tox.23679 article EN Environmental Toxicology 2022-10-11

Two new sphingolipids: oxyacanthin A [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol; 1] and B [(2S,3S,4R)-2-{[(2R,5E)-2-hydroxyoctadec-5-enoyl]amino}hexaeicosane-1,3,4-triol-1-O-β-D-glucopyranoside; 2], together with 1-octacosanol, β-sitosterol, β-sitosterol 3-O-β-D-glucopyranoside luteolin 7-O-β-glucopyranoside were isolated from the methanolic extract of whole plant Carthamus oxyacantha. Their structures elucidated using (1)H (13)C NMR spectra 2D analyses...

10.1080/14786419.2015.1075524 article EN Natural Product Research 2015-08-19

The actin cytoskeleton plays fundamental roles in ciliogenesis and the depolymerizing factor destrin regulates dynamics by treadmilling filaments increasing globular pools. However, specific developmental of have not been fully elucidated. Here, we investigated function using

10.12717/dr.2024.28.3.109 article EN Development & Reproduction 2024-09-01
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