A5100348065- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Veterinary medicine and infectious diseases
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Microscopic Colitis
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Food Quality and Safety Studies
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Inflammatory mediators and NSAID effects
- Hepatitis B Virus Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2016-2025
University of Saskatchewan
2023-2025
Seoul National University of Science and Technology
2025
Gyeongsang National University
2011-2025
University of Ulsan
2015-2024
Ulsan College
2015-2024
Asan Medical Center
2015-2024
Monash University
2022-2024
New York Institute of Technology
2021-2024
The telomeric repeat amplification protocol (TRAP) assay has been used to test telomerase activity in numerous cancer specimens.We describe primers, controls and quantification methods for the TRAP accurately measure level of clinical samples.The is reliable reproducible routine analyses can be estimate processivity activity.Telomerase a ribonucleoprotein complex that plays critical role telomere maintenance cellular immortality (1,2).Previously we have described highly sensitive PCR-based...
Proton pump inhibitor (PPI) is a prodrug which activated by acid. Activated PPI binds covalently to the gastric H(+), K(+)-ATPase via disulfide bond. Cys813 primary site responsible for inhibition of acid enzyme, where PPIs bind. Omeprazole was first introduced in market, followed pantoprazole, lansoprazole and rabeprazole. Though these share core structures benzimidazole pyridine, their pharmacokinetics pharmacodynamics are little different. Several factors must be considered understanding...
Abstract Background and Aim: Gastric cancer is a major health burden in the Asia–Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate for preventing gastric cancer. Methods: A multidisciplinary group developed statements using Delphi approach. Relevant data were presented, quality of evidence, strength recommendation, level graded. Results: Helicobacter pylori infection necessary not sufficient causal factor non‐cardia adenocarcinoma. high...
Background: Although adequate management of postoperative pain with oral analgesics is an important aspect surgical procedures, inadvertent overprescribing can lead to excess availability opioids in the community for potential diversion. The purpose our study was prospectively evaluate opioid consumption following outpatient upper-extremity procedures determine utilization patterns and develop prescribing guidelines. Methods: All patients undergoing over a consecutive 6-month period had...
Abstract Background Catechins, which are polyphenol compounds found in many plants and an important component of tea leaves, strong anti-oxidants. Research Many studies seek to enhance the effects catechins on human body boost their protective power against UV radiation. There examples positive anti-microbial, anti-viral, anti-inflammatory, anti-allergenic, anti-cancer catechins. Catechins increase penetration absorption healthy functional foods bio cosmetics into skin, thus improving...
Abstract Background The aim of this study was to evaluate the time trend seropositivity Helicobacter pylori ( H . ) over period 13 years in an asymptomatic Korean population, and investigate associated risk factors. Methods This cross-sectional nationwide multicentre surveyed anti- IgG antibodies 19,272 health check-up subjects (aged [greater than equal to]16 years) 2011. Risk factors for infection were investigated using logistic regression. Seropositivity without eradication compared...
Antimicrobial resistance of Helicobacter pylori (H. pylori) affects the efficacy eradication therapy. The aim this study was to estimate prevalence primary and secondary H. isolates antibiotics characterize risk factors associated with antimicrobial in Korea.This performed during period 2003-2012. Primary evaluated from 347 patients without any history eradication, 86 whom cultured after failure eradication. Minimal inhibitory concentration test for amoxicillin, clarithromycin,...
Abstract Background: Helicobacter pylori ‐associated gastrointestinal diseases have been widely recognized. The aims of this study were to investigate the interval change seropositivity H. between 1998 and 2005 in Korean adult population find factors related infection. Methods: Between January December 2005, a total 15,916 health check‐up subjects (aged ≥ 16 years) from all parts South Korea responded questionnaire, prevalence was investigated by measuring anti‐ H IgG antibodies....
Summary Background Atrophic gastritis and intestinal metaplasia are premalignant conditions for gastric cancer. Their reversibility by Helicobacter pylori eradication remains controversial. Aim To evaluate the of atrophic H. with long‐term follow‐up. Methods 598 subjects were prospectively enrolled followed up to 10 years. They categorised as ‐negative (n = 65), non‐eradicated 91), ‐eradicated 442). Histological assessment was performed antrum corpus Sydney classification. Results follow‐up...
Abstract Background and Aim: The prevalence of gastric cancer Helicobacter pylori infection is unacceptably high in Korea. This study was performed to evaluate the atrophic gastritis (AG) intestinal metaplasia (IM) identify their risk factors with respect H. virulence factors, environmental host Korean population without significant gastroduodenal disease. Methods: cohort consisted 389 subjects (≥ 16 years). AG IM were scored histologically using Sydney classification antrum body,...
To identify the risk of gastric cancer in first-degree relatives patients, and to determine if there is an interaction between Helicobacter pylori (H. pylori) infection family history carcinogenesis.It unclear what degree a associated with stomach Korea.From May 2003 July 2008, 428 patients 368 controls were included analyses. Logistic regression models including age, sex, cancer, residency during childhood, smoking, monthly income, spicy food diet H. status evaluated estimate odds ratios...
Background The current prevalence of primary antibiotic resistance H. pylori is not known in Korea. This study was done to evaluate the pylori, and effect point mutations 23S rRNA on rate eradication pylori. Methods were isolated from gastric mucosal biopsy specimens obtained 222 Koreans. susceptibilities isolates amoxicillin, clarithromycin, metronidazole, tetracycline, ciprofloxacin, levofloxacin examined using agar dilution method. DNA sequencing carried out detect mutations. Results...
Eleven years has passed since the guideline of Korean College Helicobacter and Upper Gastrointestinal Research group for H. pylori infection was produced in 1998. During this period research much progressed that is now regarded as major cause gastric cancer. The seroprevalence Korea found to be decreased especially below age 40s area Seoul-Gyeonggi province, annual reinfection rate up 2.94%. In aspect diagnostic tests biopsy recommended body instead antrum subjects with atrophic gastritis...
Dextran sodium sulfate (DSS)-induced colitis mouse model is used for research of inflammatory bowel disease. The aim this study was to establish the adequate conditions DSS mice model, and find useful tool measure inflammation.The 2.5% administered six male C57BL/6 4% eight at 5 or 9 weeks age. Each group consisted 6 with control in which vehicle instead DSS. were sacrificed on 7th day after administration. Body weight, diarrhea, hematochezia recorded daily. Disease activity index (DAI)...